| MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion. | MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.
Shiers S, Sahn JJ, Price TJ. | 03/22/2023 |
| SRPK1/2 and PP1alpha exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma. | SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
Liu H, Gong Z, Li K, Zhang Q, Xu Z, Xu Y., Free PMC Article | 10/23/2021 |
| MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma. | MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.
Ke XY, Chen Y, Tham VY, Lin RY, Dakle P, Nacro K, Puhaindran ME, Houghton P, Pang A, Lee VK, Ding LW, Gery S, Hill J, Chen L, Xu L, Koeffler HP., Free PMC Article | 10/16/2021 |
| MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b. | MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b.
Wang J, Da C, Su Y, Song R, Bai Z. | 07/24/2021 |
| Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis. | Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis.
Xie J, Shen K, Jones AT, Yang J, Tee AR, Shen MH, Yu M, Irani S, Wong D, Merrett JE, Lenchine RV, De Poi S, Jensen KB, Trim PJ, Snel MF, Kamei M, Martin SK, Fitter S, Tian S, Wang X, Butler LM, Zannettino ACW, Proud CG., Free PMC Article | 02/20/2021 |
| Induction of Mnk2a by splice switching oligonucleotides in glioblastoma cells activated the p38-MAPK pathway, inhibited the oncogenic properties of the cells, re-sensitized the cells to chemotherapy and inhibited glioblastoma development in vivo | Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment.
Mogilevsky M, Shimshon O, Kumar S, Mogilevsky A, Keshet E, Yavin E, Heyd F, Karni R., Free PMC Article | 07/20/2019 |
| We conclude that MNK2 overexpression in NSCLC is associated with proliferation, migration, invasion, and lower survival rates in patients via the phosphorylated eIF4E-mediated signaling pathway. | MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer.
Guo Z, Peng G, Li E, Xi S, Zhang Y, Li Y, Lin X, Li G, Wu Q, He J., Free PMC Article | 05/25/2019 |
| Data show that galeterone (gal) and VNPT55 inhibit migration and invasion of prostate cancer cells, possibly by down-regulating protein expression via antagonizing the Mnk1/2-eIF4E axis. | Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion.
Kwegyir-Afful AK, Bruno RD, Purushottamachar P, Murigi FN, Njar VC., Free PMC Article | 07/15/2017 |
| Data suggest MNK1/MNK2 stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (via decreased binding to eIF4G). | Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.
Korneeva NL, Song A, Gram H, Edens MA, Rhoads RE., Free PMC Article | 07/16/2016 |
| MNK1 and MNK2 inhibition ablates eIF4E1 phosphorylation and concurrently enhances eIF4E3 expression in diffuse large B-cell lymphoma. | MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
Landon AL, Muniandy PA, Shetty AC, Lehrmann E, Volpon L, Houng S, Zhang Y, Dai B, Peroutka R, Mazan-Mamczarz K, Steinhardt J, Mahurkar A, Becker KG, Borden KL, Gartenhaus RB., Free PMC Article | 12/12/2015 |
| Data show that interferon-gamma regulated the metabolism and mRNA translation of macrophages by targeting the kinases mTORC1 and MNK1/2, both of which converge on the selective regulator of translation initiation eukaryotic initiation factor-4E (eIF4E). | Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.
Su X, Yu Y, Zhong Y, Giannopoulou EG, Hu X, Liu H, Cross JR, Rätsch G, Rice CM, Ivashkiv LB., Free PMC Article | 10/17/2015 |
| Provide evidence for the existence of a Mnk2/eIF4E-controlled feedback loop in medulloblastoma cells that accounts for resistance to mTORC1 inhibitors. | Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells.
Eckerdt F, Beauchamp E, Bell J, Iqbal A, Su B, Fukunaga R, Lulla RR, Goldman S, Platanias LC., Free PMC Article | 06/27/2015 |
| Data suggest that a combined pharmacologic inhibition of mTORC1 and Mnk1/2 kinases offers a therapeutic opportunity in blast crisis-chronic myeloid leukemia (BC-CML). | Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.
Teo T, Yu M, Yang Y, Gillam T, Lam F, Sykes MJ, Wang S. | 04/25/2015 |
| These findings provide evidence for key and essential roles of the Mnk kinase pathway in the generation of the antineoplastic effects of type I IFNs in Jak2V617F-dependent myeloproliferative neoplasms. | Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors.
Mehrotra S, Sharma B, Joshi S, Kroczynska B, Majchrzak B, Stein BL, McMahon B, Altman JK, Licht JD, Baker DP, Eklund EA, Wickrema A, Verma A, Fish EN, Platanias LC., Free PMC Article | 11/30/2013 |
| eIF4E phosphorylation is enhanced by Rapamycin, which activates Mnk2a | Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a).
Stead RL, Proud CG. | 10/26/2013 |
| MNK2-dependent phosphorylation of eIF4E represents a novel drug resistance, pro-survival pathway in pancreatic ductal carcinoma. | Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway.
Adesso L, Calabretta S, Barbagallo F, Capurso G, Pilozzi E, Geremia R, Delle Fave G, Sette C. | 08/10/2013 |
| siRNA-mediated Mnk1/2 knockdown results in partial reversal of the suppressive effects of IFNgamma on human CD34+-derived myeloid (CFU-GM) and erythroid (BFU-E) progenitors. | Essential role for Mnk kinases in type II interferon (IFNgamma) signaling and its suppressive effects on normal hematopoiesis.
Joshi S, Sharma B, Kaur S, Majchrzak B, Ueda T, Fukunaga R, Verma AK, Fish EN, Platanias LC., Free PMC Article | 04/16/2011 |
| The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization | The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization.
Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG., Free PMC Article | 01/21/2010 |
| Mnk2 can interact with CBC(VHL) complex, and is probably one of the new substrates of the CBC(VHL) complex. | Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex.
Wang P, Wang X, Wang F, Cai T, Luo Y. | 01/21/2010 |