| GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. | GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.
Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z., Free PMC Article | 03/13/2024 |
| GRB2 is a BECN1 interacting protein that regulates autophagy. | GRB2 is a BECN1 interacting protein that regulates autophagy.
Montero-Vergara J, Plachetta K, Kinch L, Bernhardt S, Kashyap K, Levine B, Thukral L, Vetter M, Thomssen C, Wiemann S, Peña-Llopis S, Jendrossek V, Vega-Rubin-de-Celis S., Free PMC Article | 01/26/2024 |
| Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway. | Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway.
Tang Y, Yang K, Liu Q, Ma Y, Zhu H, Tang K, Geng C, Xie J, Zhuo D, Wu W, Jin L, Xiao W, Wang J, Zhu Q, Liu J., Free PMC Article | 10/12/2023 |
| GRB2 serves as a viable target against skin fibrosis in systemic sclerosis by regulating endothelial cell apoptosis. | GRB2 serves as a viable target against skin fibrosis in systemic sclerosis by regulating endothelial cell apoptosis.
Huang Y, Zhao H, Shi X, Liu J, Lin JM, Ma Q, Jiang S, Pu W, Ma Y, Liu J, Wu W, Wang J, Liu Q. | 10/10/2023 |
| RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma. | RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma.
Zhou J, Tu D, Peng R, Tang Y, Deng Q, Su B, Wang S, Tang H, Jin S, Jiang G, Wang Q, Jin X, Zhang C, Cao J, Bai D., Free PMC Article | 08/30/2023 |
| The Role of the LINC01234/miR-433-3p/GRB2 ceRNA Network in NSCLC Cell Malignant Proliferation. | The Role of the LINC01234/miR-433-3p/GRB2 ceRNA Network in NSCLC Cell Malignant Proliferation.
Wei W, Wang C, Zhang J, Wang L, Wei L, Huang H. | 06/1/2023 |
| Evaluation of the relationship between miR-1271 and GRB2 gene in endometriosis. | Evaluation of the relationship between miR-1271 and GRB2 gene in endometriosis.
Yarahmadi G, Fazeli J, Dehghanian M, Mehrjardi MYV, Javaheri A, Kalantar SM. | 10/8/2022 |
| A new bioinformatics approach identifies overexpression of GRB2 as a poor prognostic biomarker for prostate cancer. | A new bioinformatics approach identifies overexpression of GRB2 as a poor prognostic biomarker for prostate cancer.
Iwata T, Sedukhina AS, Kubota M, Oonuma S, Maeda I, Yoshiike M, Usuba W, Minagawa K, Hames E, Meguro R, Cho S, Chien SHH, Urabe S, Pae S, Palanisamy K, Kumai T, Yudo K, Kikuchi E, Sato K., Free PMC Article | 12/11/2021 |
| FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2. | FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2.
DeLuca JM, Murphy MK, Wang X, Wilson TJ., Free PMC Article | 12/4/2021 |
| The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands. | The intramolecular allostery of GRB2 governing its interaction with SOS1 is modulated by phosphotyrosine ligands.
Kazemein Jasemi NS, Herrmann C, Magdalena Estirado E, Gremer L, Willbold D, Brunsveld L, Dvorsky R, Ahmadian MR. | 12/4/2021 |
| Mechanism of p38 MAPK-induced EGFR endocytosis and its crosstalk with ligand-induced pathways. | Mechanism of p38 MAPK-induced EGFR endocytosis and its crosstalk with ligand-induced pathways.
Perez Verdaguer M, Zhang T, Paulo JA, Gygi S, Watkins SC, Sakurai H, Sorkin A., Free PMC Article | 10/9/2021 |
| Grb2 binding induces phosphorylation-independent activation of Shp2. | Grb2 binding induces phosphorylation-independent activation of Shp2.
Lin CC, Wieteska L, Suen KM, Kalverda AP, Ahmed Z, Ladbury JE., Free PMC Article | 08/7/2021 |
| Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis. | Transcription factor PAX4 facilitates gastric cancer progression through interacting with miR-27b-3p/Grb2 axis.
Zhang Y, Ding L, Ni Q, Tao R, Qin J., Free PMC Article | 07/24/2021 |
| Targeting the Interaction between the SH3 Domain of Grb2 and Gab2. | Targeting the Interaction between the SH3 Domain of Grb2 and Gab2.
Malagrinò F, Coluccia A, Bufano M, Regina G, Puxeddu M, Toto A, Visconti L, Paone A, Magnifico MC, Troilo F, Cutruzzolà F, Silvestri R, Gianni S., Free PMC Article | 06/19/2021 |
| Loss of GRB2 associated binding protein 1 in arteriosclerosis obliterans promotes host autophagy. | Loss of GRB2 associated binding protein 1 in arteriosclerosis obliterans promotes host autophagy.
Ye M, Guo XJ, Kan KJ, Ni QH, Chen JQ, Wang H, Qian X, Xue GH, Deng HY, Zhang L., Free PMC Article | 05/15/2021 |
| SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations. | SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations.
Liao TJ, Jang H, Fushman D, Nussinov R., Free PMC Article | 04/3/2021 |
| Long noncoding RNA AC092171.4 promotes hepatocellular carcinoma progression by sponging microRNA-1271 and upregulating GRB2. | Long noncoding RNA AC092171.4 promotes hepatocellular carcinoma progression by sponging microRNA-1271 and upregulating GRB2.
Sun C, Huang S, Hou Y, Li Z, Xia D, Zhang L, Zhang Y, Cai Y, Wang Z, Zhou Q, He X, Wu L., Free PMC Article | 03/27/2021 |
| Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2. | Molecular Dynamics model of peptide-protein conjugation: case study of covalent complex between Sos1 peptide and N-terminal SH3 domain from Grb2.
Luzik DA, Rogacheva ON, Izmailov SA, Indeykina MI, Kononikhin AS, Skrynnikov NR., Free PMC Article | 11/21/2020 |
| Downregulation of long non-coding RNA ZXF1 restricts cell survival by targeting miR-634-GRB2 in lung adenocarcinoma. | Downregulation of long non-coding RNA ZXF1 restricts cell survival by targeting miR-634-GRB2 in lung adenocarcinoma.
Ren X, Xu N, Zhang Y, Wang T. | 11/21/2020 |
| Mapping the allosteric network within a SH3 domain. | Mapping the allosteric network within a SH3 domain.
Malagrinò F, Troilo F, Bonetti D, Toto A, Gianni S., Free PMC Article | 10/31/2020 |
| Evaluation of genetic susceptibility between systemic lupus erythematosus and GRB2 gene. | Evaluation of genetic susceptibility between systemic lupus erythematosus and GRB2 gene.
Xu M, Liu Y, Li X, Cheng C, Liu Y, Dong W, Du S, Xiao S., Free PMC Article | 10/24/2020 |
| NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity. | NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity.
Wilton KM, Overlee BL, Billadeau DD., Free PMC Article | 09/26/2020 |
| Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p. | Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p.
Li X, Yang B, Ren H, Xiao T, Zhang L, Li L, Li M, Wang X, Zhou H, Zhang W., Free PMC Article | 09/12/2020 |
| Grb2 interacts with PTEN and Rad51 to regulate genomic stability in DNA damage response by mediating the nuclear translocation of PTEN to affect the expression of Rad51. | Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response.
Hou B, Xu S, Xu Y, Gao Q, Zhang C, Liu L, Yang H, Jiang X, Che Y., Free PMC Article | 08/12/2020 |
| E2F1-induced overexpression of SBF2-AS1 promotes the expression of GRB2 by targeting miR-362-3p to facilitate the metastasis of NSCLC | E2F1-Induced Overexpression of Long Noncoding RNA SBF2-AS1 Promotes Non-Small-Cell Lung Cancer Metastasis Through Regulating miR-362-3p/GRB2 Axis.
Wang A, Wang J. | 07/25/2020 |