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    Adipor1 adiponectin receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289036, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Crosstalk relationship between adiponectin receptors, PPAR-gamma and alpha-adrenoceptors in renal vasculature of diabetic WKYs.

    Crosstalk relationship between adiponectin receptors, PPAR-γ and α-adrenoceptors in renal vasculature of diabetic WKYs.
    Afzal S, Sattar MA, Eseyin OA, Attiq A, Johns EJ.

    08/28/2024
    Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats.

    Adiponectin receptor 1 could explain the sex differences in molecular basis of cognitive improvements induced by exercise training in type 2 diabetic rats.
    Rajizadeh MA, Moslemizadeh A, Hosseini MS, Rafiei F, Soltani Z, Khoramipour K., Free PMC Article

    11/28/2023
    The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.

    The ontogenies of endometrial and myometrial leptin and adiponectin receptors in pregnant rats: Their putative impact on uterine contractility.
    Schaffer A, Ducza E, Bódi N, Bagyánszki M, Szalai Z, Mirdamadi M, Barna T, Szűcs KF, Gáspár R.

    04/16/2022
    Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin resistance by activating AdipoR1 in peri-/post-menopausal rats.

    Polyphenolic-rich Cissus quadrangularis extract ameliorates insulin resistance by activating AdipoR1 in peri-/post-menopausal rats.
    Syed AA, Reza MI, Singh P, Husain A, Dadge S, Gayen JR.

    03/12/2022
    GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.

    GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
    Zhang Y, Wang S, Huang H, Zeng A, Han Y, Zeng C, Zheng S, Ren H, Wang Y, Huang Y, Jose PA, Ma XL, Zeng C, Chen K., Free PMC Article

    03/28/2021
    High salt is an important suppressor of cardioprotective APN and AdipoR1 in cardiac myocytes.

    Regulation of the cardioprotective adiponectin and its receptor AdipoR1 by salt.
    Arnold N, Mahmood A, Ramdas M, Ehlinger PP, Pulakat L., Free PMC Article

    03/25/2017
    A High-fat maternal diet decreases adiponectin receptor 1 expression in the offspring.

    A high-fat maternal diet decreases adiponectin receptor-1 expression in offspring.
    Hou M, Chu Z, Liu T, Lv H, Sun L, Wang B, Huang J, Yan W.

    09/12/2015
    In a model of NAFLD, Adipor1 was primarily expressed in the cytoplasm of hepatocytes.

    Effects of a low-fat diet on the hepatic expression of adiponectin and its receptors in rats with NAFLD.
    Ma H, You GP, Cui F, Chen LF, Yang XJ, Chen LG, Lu HD, Zhang WQ.

    08/29/2015
    AdipoR1 and the adaptor protein APPL1 mediated the protective effects of gAcrp. In addition, the function of adiponectin and phosphorylation of AMPK were prominently diminished by inhibition of PI3K.

    AdipoR1/APPL1 potentiates the protective effects of globular adiponectin on angiotensin II-induced cardiac hypertrophy and fibrosis in neonatal rat atrial myocytes and fibroblasts.
    Cao T, Gao Z, Gu L, Chen M, Yang B, Cao K, Huang H, Li M., Free PMC Article

    04/18/2015
    Adipo R1 expression in kidney is increased in chronic renal failure

    Changes of adiponectin and its receptors in rats following chronic renal failure.
    Yu Y, Bao BJ, Fan YP, Shi L, Li SQ.

    08/30/2014
    Adiponectin functions as a promoter of salivary secretion in rat submandibular glands via activation of Adiponectin receptors, AMPK, and paracellular permeability.

    Adiponectin increases secretion of rat submandibular gland via adiponectin receptors-mediated AMPK signaling.
    Ding C, Li L, Su YC, Xiang RL, Cong X, Yu HK, Li SL, Wu LL, Yu GY., Free PMC Article

    12/21/2013
    AdipoR1 and AdipoR2 gene expression is regulated by thyroid hormones in hypo- and hyperthyroidism.

    AdipoR1 and AdipoR2 gene expression are regulated by thyroid hormones in adipose tissue.
    Seifi S, Nazifi S, Tabandeh MR, Saeb M.

    09/14/2013
    AngII inhibits cardiac AdipoR1 expression in vivo and in vitro and AT1 receptor/ROS/ERK1/2/c-Myc pathway is required for the downregulation of AdipoR1 induced by AngII

    Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.
    Li L, Zhang ZG, Lei H, Wang C, Wu LP, Wang JY, Fu FY, Zhu WG, Wu LL., Free PMC Article

    07/13/2013
    The results demonstrate that human biosynthetic insulin down-regulates both AdipoR1 and AdipoR2 mRNAs levels in a biphasic manner in L6 and PAC1 cells.

    Insulin-regulated expression of adiponectin receptors in muscle and fat cells.
    Sattar AA, Sattar R.

    04/27/2013
    Telmisartan upregulates aortic expression of Adipor1 in type 2 diabetic rats.

    Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats.
    Guo Z, Zhang R, Li J, Xu G., Free PMC Article

    03/23/2013
    the effects of Caloric restriction on adiposity and gene expression of adiponectin, its receptors (AdipoR1 in adipose tissue and in isolated adipocytes

    Caloric restriction increases adiponectin expression by adipose tissue and prevents the inhibitory effect of insulin on circulating adiponectin in rats.
    Ding Q, Ash C, Mracek T, Merry B, Bing C.

    12/8/2012
    We showed an increase in hypothalamic TLR4, MyD88 and NFkappaBp65 expression and reduction hypothalamic AdipoR1 expression in rats fed trans fatty acids.

    Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NFκBp65 signaling in adult offspring.
    Pimentel GD, Lira FS, Rosa JC, Oliveira JL, Losinskas-Hachul AC, Souza GI, das Graças T do Carmo M, Santos RV, de Mello MT, Tufik S, Seelaender M, Oyama LM, Oller do Nascimento CM, Watanabe RH, Ribeiro EB, Pisani LP.

    06/9/2012
    Insulin inhibits myocardial AdipoR1 expression via PI3K/Akt and FoxO1 pathways, and FoxO1 mediates AdipoR1 transcription by binding to its promoter directly.

    Insulin decreases myocardial adiponectin receptor 1 expression via PI3K/Akt and FoxO1 pathway.
    Cui XB, Wang C, Li L, Fan D, Zhou Y, Wu D, Cui QH, Fu FY, Wu LL.

    05/12/2012
    hypoxia-reoxygenation -induced ROS generation and activation of the intrinsic apoptotic pathway was prevented by adiponectin via AdipoR1/APPL1 signaling and increased anti-oxidant potential

    Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosis.
    Park M, Youn B, Zheng XL, Wu D, Xu A, Sweeney G., Free PMC Article

    08/27/2011
    AdipoR1 and insulin receptor substrate isoforms might be crucially important regulators for the synthesis and oxidation of fatty acids in the liver of Nonalcoholic steatohepatitis

    Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model.
    Matsunami T, Sato Y, Ariga S, Sato T, Shimomura T, Kashimura H, Hasegawa Y, Yukawa M.

    07/23/2011
    These results suggest that the levels of myocardial adiponectin and its receptor 1 are decreased in type 2 diabetic rats

    Effect of telmisartan on the expression of cardiac adiponectin and its receptor 1 in type 2 diabetic rats.
    Guo Z, Zheng C, Qin Z, Wei P.

    04/2/2011
    investigation of expression and physiological role of AdipoR1 (also AdipoR2 and adopinectin) in adrenal cortex

    Adiponectin and adiponectin receptor system in the rat adrenal gland: ontogenetic and physiologic regulation, and its involvement in regulating adrenocortical growth and steroidogenesis.
    Paschke L, Zemleduch T, Rucinski M, Ziolkowska A, Szyszka M, Malendowicz LK.

    01/1/2011
    in the context of physiologically relevant mixtures of adipokines, adiponectin may be an important determinant of positive cross talk between adipocytes and skeletal muscle

    Coculture with primary visceral rat adipocytes from control but not streptozotocin-induced diabetic animals increases glucose uptake in rat skeletal muscle cells: role of adiponectin.
    Vu V, Kim W, Fang X, Liu YT, Xu A, Sweeney G.

    08/26/2010
    demonstrated that subfornical organ neurons are sensitive to adiponectin (ADP) via AdipoR1 and AdipoR2 and that the response to ADP changes during food restricted conditions, suggesting that SFO's response to ADP is modulated by energy status

    Actions of adiponectin on the excitability of subfornical organ neurons are altered by food deprivation.
    Alim I, Fry WM, Walsh MH, Ferguson AV.

    08/9/2010
    Results characterise the expression and interaction of adiponectin receptors 1 and 2 and adiponectin, respectively, in regulating the activity of growth hormone-secreting cells.

    Adiponectin regulate growth hormone secretion via adiponectin receptor mediated Ca(2+) signalling in rat somatotrophs in vitro.
    Steyn FJ, Boehme F, Vargas E, Wang K, Parkington HC, Rao JR, Chen C.

    01/21/2010
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