| Epigenetic signature discriminates lymphatic metastasis in BRAF wild-type thyroid carcinoma: methylation role of GRIK2. | Epigenetic signature discriminates lymphatic metastasis in BRAF wild-type thyroid carcinoma: methylation role of GRIK2.
Peng J, Zhang Q, Lin F, Ke C, Deng W, Yang A, Su X. | 12/4/2023 |
| The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability. | The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability.
Gorlewicz A, Barthet G, Zucca S, Vincent P, Griguoli M, Grosjean N, Wilczynski G, Mulle C. | 07/23/2022 |
| Kainate receptor modulation by NETO2. | Kainate receptor modulation by NETO2.
He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y. | 02/5/2022 |
| Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. | Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders.
Stolz JR, Foote KM, Veenstra-Knol HE, Pfundt R, Ten Broeke SW, de Leeuw N, Roht L, Pajusalu S, Part R, Rebane I, Õunap K, Stark Z, Kirk EP, Lawson JA, Lunke S, Christodoulou J, Louie RJ, Rogers RC, Davis JM, Innes AM, Wei XC, Keren B, Mignot C, Lebel RR, Sperber SM, Sakonju A, Dosa N, Barge-Schaapveld DQCM, Peeters-Scholte CMPCD, Ruivenkamp CAL, van Bon BW, Kennedy J, Low KJ, Ellard S, Pang L, Junewick JJ, Mark PR, Carvill GL, Swanson GT., Free PMC Article | 09/18/2021 |
| This study suggests that the rs2227283 polymorphism of the GRIK2 gene is related to aggressive behaviors in bipolar manic patients and that the A/A genotype and A allele may increase the risk of the aggressive behavior in bipolar manic patients. | Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population.
Ma H, Xun G, Zhang R, Yang X, Cao Y., Free PMC Article | 07/4/2020 |
| Both the GRIK2 rs4840200-T and rs3213607-A, and the interactions between rs4840200 and rs9390754 are related to the increased risk of epilepsy risk. | Interaction among GRIK2 gene on epilepsy susceptibility in Chinese children.
Xiong S, Wang Y, Li H, Zhang X. | 07/13/2019 |
| These results indicate involvement of GRIK2 in senescence and suggests GRIK2 as a potential target for therapeutic intervention of cancer cells. | Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells.
Zhawar VK, Kandpal RP, Athwal RS., Free PMC Article | 04/13/2019 |
| Study identifies differentially variable CpG sites in GRIK2 gene displaying increased expression in patients with chronic obstructive pulmonary disease. | Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.
Clifford RL, Fishbane N, Patel J, MacIsaac JL, McEwen LM, Fisher AJ, Brandsma CA, Nair P, Kobor MS, Hackett TL, Knox AJ., Free PMC Article | 03/2/2019 |
| results suggest that PKC SUMOylation is an important regulator of the 14-3-3 and GluK2a protein complex and may contribute to regulate the decay kinetics of kainate receptor-excitatory postsynaptic currents | PKC SUMOylation inhibits the binding of 14-3-3τ to GluK2.
Li X, Wang Y, Zhu A, Zhou J, Li Y., Free PMC Article | 08/18/2018 |
| these findings indicate that GRIK2 has a role in the maintenance of urothelial cancer stem cells and that GRIK2 and ALDH1 can be prognosis prediction markers for urinary tract carcinomas | GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis.
Inoue R, Hirohashi Y, Kitamura H, Nishida S, Murai A, Takaya A, Yamamoto E, Matsuki M, Tanaka T, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Sato N, Masumori N, Torigoe T., Free PMC Article | 03/24/2018 |
| TTBK2 down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5-dependent endocytosis. | Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2.
Nieding K, Matschke V, Meuth SG, Lang F, Seebohm G, Strutz-Seebohm N. | 02/4/2017 |
| In the Han population in Central China, the polymorphisms of SNP rs9390754 in the GRIK2 gene may be associated with epilepsy susceptibility. | [Association between glutamate receptor 2 polymorphisms and epilepsy in children].
Wang X, Zhu TJ, Wan ZT, Zhu XM., Free PMC Article | 09/17/2016 |
| Study demonstrates that co-assembly of recombinant kainate receptors (GluK1 and GluK2) with the Neto1 and Neto2 auxiliary subunits alters their onset and recovery from desensitization in a subunit-dependent manner | The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.
Fisher JL., Free PMC Article | 09/3/2016 |
| This study found in GRIK2 (glutamate receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression. | Astrocytic abnormalities and global DNA methylation patterns in depression and suicide.
Nagy C, Suderman M, Yang J, Szyf M, Mechawar N, Ernst C, Turecki G., Free PMC Article | 03/5/2016 |
| This study showed that Gluk2 association with obsessive-compulsive disorder. | Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
Mattheisen M, Samuels JF, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Geller DA, Murphy DL, Knowles JA, Grados MA, Riddle MA, Rasmussen SA, McLaughlin NC, Nurmi EL, Askland KD, Qin HD, Cullen BA, Piacentini J, Pauls DL, Bienvenu OJ, Stewart SE, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Lange C, Nestadt G., Free PMC Article | 03/5/2016 |
| Parkin interacts with the kainate receptor GluK2 subunit and regulates KAR function. | Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M, Chieregatti E, Mulle C, Passafaro M, Sassone J., Free PMC Article | 11/28/2015 |
| High risk genetic markers of paranoid schizophrenia were GRIK2*ATG and GRIK2*TGG in Tatars. | [Glutamate receptors genes polymorphism and the risk of paranoid schizophrenia in Russians and tatars from the Republic of Bashkortostan].
Gareeva AE, Khusnutdinova EK. | 06/6/2015 |
| The present study reveals an additional mechanism for the regulation of GluK2-containing kainate receptors by Src family kinases, which may be of pathological significance in ischemic stroke. | Tyrosine phosphorylation of GluK2 up-regulates kainate receptor-mediated responses and downstream signaling after brain ischemia.
Zhu QJ, Kong FS, Xu H, Wang Y, Du CP, Sun CC, Liu Y, Li T, Hou XY., Free PMC Article | 04/25/2015 |
| we found no association between rs1556995 in GRIK2 and clozapine-induced obsessive-compulsive (OC) symptoms, implying that that GRIK2 may not play a role in the development of OC symptoms in schizophrenia patients | Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms.
Cai J, Zhang W, Yi Z, Lu W, Wu Z, Chen J, Yu S, Fang Y, Zhang C. | 06/14/2014 |
| Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state. | Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.
Daniels BA, Andrews ED, Aurousseau MR, Accardi MV, Bowie D., Free PMC Article | 03/8/2014 |
| 14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs. | Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins.
Sun C, Qiao H, Zhou Q, Wang Y, Wu Y, Zhou Y, Li Y., Free PMC Article | 11/16/2013 |
| Kainate receptor GluK2a post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis | Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis.
Copits BA, Swanson GT., Free PMC Article | 06/1/2013 |
| Eight chromosome 6 SNPs, having the most significant differences, were delineated: rs10499298, rs10499299, rs17827966, rs1224329, rs1150790, rs713050, rs2518344 and rs487083; all were associated with genes GRIK2. | Association of genes on chromosome 6, GRIK2 , TMEM217 and TMEM63B (linked to MRPL14 ) with diabetic retinopathy.
Lin HJ, Huang YC, Lin JM, Wu JY, Chen LA, Tsai FJ. | 06/1/2013 |
| The ACAG haplotype in the 13th haplotype block of the GRIK2 gene was associated with somatic anxiety. | Genetic association study of individual symptoms in depression.
Myung W, Song J, Lim SW, Won HH, Kim S, Lee Y, Kang HS, Lee H, Kim JW, Carroll BJ, Kim DK. | 05/4/2013 |
| Comprehensive analytical methods applied to a much larger sample than in previous studies do not support a role for GRIK2 as a genetic modifier of age at onset of clinical symptoms in Huntington's disease. | TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.
Lee JH, Lee JM, Ramos EM, Gillis T, Mysore JS, Kishikawa S, Hadzi T, Hendricks AE, Hayden MR, Morrison PJ, Nance M, Ross CA, Margolis RL, Squitieri F, Gellera C, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Landwehrmeyer GB, Registry Study of the European Huntington's Disease Network, Shoulson I, Huntington Study Group COHORT project, Myers RH, MacDonald ME, Gusella JF., Free PMC Article | 11/24/2012 |