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    HIPK2 homeodomain interacting protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 28996, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation.

    CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation.
    Zeng X, Tang J, Zhang Q, Wang C, Qi J, Wei Y, Xu J, Yang K, Zhou Z, Wu H, Luo J, Jiang Y, Song Z, Wu J, Wu J., Free PMC Article

    10/2/2024
    Circular RNA circHIPK2 inhibits colon cancer cells through miR-373-3p/RGMA axis.

    Circular RNA circHIPK2 inhibits colon cancer cells through miR-373-3p/RGMA axis.
    Lun J, Zhang Y, Yu M, Zhai W, Zhu L, Liu H, Guo J, Zhang G, Qiu W, Fang J.

    07/10/2024
    ZC3H13 Accelerates Keloid Formation by Mediating N[6]-methyladenosine Modification of HIPK2.

    ZC3H13 Accelerates Keloid Formation by Mediating N(6)-methyladenosine Modification of HIPK2.
    Fu M, Chen Y, Shi X.

    07/9/2024
    Circ_0008410 contributes to fibroblast-like synoviocytes dysfunction by regulating miR-149-5p/HIPK2 axis.

    Circ_0008410 contributes to fibroblast-like synoviocytes dysfunction by regulating miR-149-5p/HIPK2 axis.
    Su W, Ye Z, Wang G, Huang H, Fang Y.

    03/13/2024
    MicroRNA-483-3p Inhibitor Ameliorates Sepsis-Induced Intestinal Injury by Attenuating Cell Apoptosis and Cytotoxicity Via Regulating HIPK2.

    MicroRNA-483-3p Inhibitor Ameliorates Sepsis-Induced Intestinal Injury by Attenuating Cell Apoptosis and Cytotoxicity Via Regulating HIPK2.
    Wang Z, Qin X, Yuan J, Yin H, Qu R, Zhong C, Ding W.

    02/2/2024
    Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and prediction of therapeutic effects in major depressive disorder.

    Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and prediction of therapeutic effects in major depressive disorder.
    Yu X, Fan Z, Yang T, Li H, Shi Y, Ye L, Huang R.

    12/27/2023
    miR-147b is an oncomiR acting synergistically with HIPK2 to promote pancreatic carcinogenesis.

    miR-147b is an oncomiR acting synergistically with HIPK2 to promote pancreatic carcinogenesis.
    Wang G, Ma Z, Song C, Wang X, Zhou Z.

    10/6/2023
    Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2.

    Adipose-derived stem cell exosome NFIC improves diabetic foot ulcers by regulating miR-204-3p/HIPK2.
    Huang H, Zhu W, Huang Z, Zhao D, Cao L, Gao X., Free PMC Article

    09/20/2023
    Determination of homeodomain interacting protein kinase 2 polymorphisms rs2058265, rs6464214, and rs7456421 in patients with kidney stone.

    Determination of homeodomain interacting protein kinase 2 polymorphisms rs2058265, rs6464214, and rs7456421 in patients with kidney stone.
    Ceylan C, Gokhan-Doluoglu O, Taştemur S, Keleş I, Ceylan G, Cevdet-Ceylan A, Uzun E, Tokat E.

    09/13/2023
    HIPK2 in the physiology of nervous system and its implications in neurological disorders.

    HIPK2 in the physiology of nervous system and its implications in neurological disorders.
    Sardina F, Conte A, Paladino S, Pierantoni GM, Rinaldo C., Free PMC Article

    05/22/2023
    LncRNA PSCK6-AS1-HIPK2 promotes Th1 differentiation via STAT1 phosphorylation to regulate colitis-related mucosal barrier damage.

    LncRNA PSCK6-AS1-HIPK2 promotes Th1 differentiation via STAT1 phosphorylation to regulate colitis-related mucosal barrier damage.
    Han C, Sheng Y, Wang J, Zhou X, Li W, Zhang C, Wu S, Yang Y, Ruan S.

    04/10/2023
    HIPK2 in cancer biology and therapy: Recent findings and future perspectives.

    HIPK2 in cancer biology and therapy: Recent findings and future perspectives.
    Conte A, Valente V, Paladino S, Pierantoni GM.

    12/10/2022
    Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling.

    Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling.
    Zhou Q, Meng D, Li F, Zhang X, Liu L, Zhu Y, Liu S, Xu M, Deng J, Lei Z, Sluijter JPG, Xiao J., Free PMC Article

    11/26/2022
    miR-4653-3p overexpression is associated with a poor prognosis of pancreatic ductal adenocarcinoma via HIPK2 downregulation.

    miR-4653-3p overexpression is associated with a poor prognosis of pancreatic ductal adenocarcinoma via HIPK2 downregulation.
    Hirabayashi K, Miyazawa M, Takanashi Y, Morimachi M, Kawanishi A, Saika T, Nakagohri T, Nakamura N., Free PMC Article

    11/5/2022
    The malignant property of circHIPK2 for angiogenesis and chemoresistance in non-small cell lung cancer.

    The malignant property of circHIPK2 for angiogenesis and chemoresistance in non-small cell lung cancer.
    Ren M, Song X, Niu J, Tang G, Sun Z, Li Y, Kong F.

    09/24/2022
    HIPK2 Cooperates with KRAS Signaling and Associates with Colorectal Cancer Progression.

    HIPK2 Cooperates with KRAS Signaling and Associates with Colorectal Cancer Progression.
    Di Segni M, Virdia I, Verdina A, Amoreo CA, Baldari S, Toietta G, Diodoro MG, Mottolese M, Sperduti I, Moretti F, Buglioni S, Soddu S, Di Rocco G.

    05/7/2022
    Exercise and cardioprotection: A ""HIP"" side of HIPK2 in the heart.

    Exercise and cardioprotection: A "HIP" side of HIPK2 in the heart.
    Phrommintikul A, Chattipakorn SC, Chattipakorn N., Free PMC Article

    04/9/2022
    MiR-221-3p targets HIPK2 to promote diabetic wound healing.

    MiR-221-3p targets HIPK2 to promote diabetic wound healing.
    Yu Q, Liu L, Zhang X, Chang H, Ma S, Xie Z, Tang S, Ju X, Zhu H, Shen B, Zhang Q.

    03/12/2022
    Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2.

    Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2.
    Kim DH, Park H, Choi YJ, Kang MH, Kim TK, Pack CG, Choi CM, Lee JC, Rho JK., Free PMC Article

    01/29/2022
    Overexpression of microRNA-100-5p attenuates the endothelial cell dysfunction by targeting HIPK2 under hypoxia and reoxygenation treatment.

    Overexpression of microRNA-100-5p attenuates the endothelial cell dysfunction by targeting HIPK2 under hypoxia and reoxygenation treatment.
    Zheng H, Sun Y, Shu X, Gao Q, Chen X.

    01/29/2022
    Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.

    Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases involved in transcriptional regulation.
    Kaltheuner IH, Anand K, Moecking J, Düster R, Wang J, Gray NS, Geyer M., Free PMC Article

    12/18/2021
    Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity.

    Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity.
    D'Orazi G, Garufi A, Cirone M.

    11/27/2021
    CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis.

    CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis.
    Li X, Qu M, Zhang J, Chen K, Ma X., Free PMC Article

    10/30/2021
    HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer.

    HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer.
    Verdina A, Di Segni M, Amoreo CA, Sperduti I, Buglioni S, Mottolese M, Di Rocco G, Soddu S.

    10/23/2021
    Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis.

    Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP-HIPK2 axis.
    Jin X, Qing S, Li Q, Zhuang H, Shen L, Li J, Qi H, Lin T, Lin Z, Wang J, Cao X, Yang J, Ma Q, Cong L, Xi Y, Fang S, Meng X, Gong Z, Ye M, Wang S, Wang C, Gao K., Free PMC Article

    07/31/2021
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