| Impact of GRIK4 gene polymorphisms on cognitive dysfunction in patients with major depression. | Impact of GRIK4 gene polymorphisms on cognitive dysfunction in patients with major depression.
Pu M, Wang X, Zhang J. | 08/7/2021 |
| In addition, while GRIK4 was not associated with sertraline tolerability and response, both HTR2A and SLC6A4 could influence tolerability and accelerate treatment response in pediatric patients. | Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders.
Poweleit EA, Aldrich SL, Martin LJ, Hahn D, Strawn JR, Ramsey LB. | 08/12/2020 |
| GluK4 deletion carriers who had a mental health problem (predominately depression) showed better performance in visuo-spatial ability and mental processing speed compared to individuals with mental health problems homozygous for the insertion. | A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort.
Koromina M, Flitton M, Mellor IR, Knight HM. | 07/11/2020 |
| the GRIK4 polymorphisms genotypes were distributed as follows: rs79526501: CC696: 16, CG302: 274, GG31: 35; rs11218016: CC455: 483, CT473: 436, TT101: 108; and rs6589847: AA32: 29, AG307: 314, GG690: 686. However, there was no significant difference in allelic or genotypic frequency distributions between patients and controls. We did not find any significant association between GRIK4 polymorphisms and schizophrenia. | No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population.
Ren D, Xu F, Bi Y, Niu W, Zhang R, Hu J, Guo Z, Cao Y, Huang X, Wu X, Yang F, Wang L, Li W, Xu Y, He L, Yu T, Li X, He G. | 07/21/2018 |
| Results firstly indicated that rs56275759 of GRIK4 gene might be associated with major depressive disorder in Chinese Han population. | Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population.
Ren D, Bi Y, Xu F, Niu W, Zhang R, Hu J, Guo Z, Wu X, Cao Y, Huang X, Yang F, Wang L, Li W, Xu Y, He L, Yu T, He G, Li X. | 05/5/2018 |
| This study showed the lower GluK4 mRNA levels in pregnant women. | AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.
Bhandage AK, Jin Z, Hellgren C, Korol SV, Nowak K, Williamsson L, Sundström-Poromaa I, Birnir B. | 08/19/2017 |
| Data suggest the involvement of glutamate receptor, ionotropic, kainate 4 protein (GRIK4) in treatment-resistant depression (TRD) and in the risk of developing psychotic symptoms during depressive episodes. | The role of GRIK4 gene in treatment-resistant depression.
Milanesi E, Bonvicini C, Congiu C, Bortolomasi M, Gainelli G, Gennarelli M, Minelli A., Free PMC Article | 04/9/2016 |
| Subjects possessing the C allele or CC genotype of the GRIK4 polymorphism rs1954787 are more likely to respond to antidepressant treatment. | GRIK4 polymorphism and its association with antidepressant response in depressed patients: a meta-analysis.
Kawaguchi DM, Glatt SJ., Free PMC Article | 10/24/2015 |
| The deletion allele affords protection against bipolar disorder through increased KA1 protein abundance in neuronal cells. | GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status.
Knight HM, Walker R, James R, Porteous DJ, Muir WJ, Blackwood DH, Pickard BS. | 04/21/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/23/2011 |
| Activation of kainate receptors could serve as a novel mechanism for enhancing B cell activation and immunoglobulin production. | Glutamate signaling through the kainate receptor enhances human immunoglobulin production.
Sturgill JL, Mathews J, Scherle P, Conrad DH., Free PMC Article | 06/18/2011 |
| The GRIK4 single nucleotide polymorphism (rs12800734) shows a strong association with disease remission in antidepressant treatment. | Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.
Horstmann S, Lucae S, Menke A, Hennings JM, Ising M, Roeske D, Müller-Myhsok B, Holsboer F, Binder EB, Horstmann S, Lucae S, Menke A, Hennings JM, Ising M, Roeske D, Müller-Myhsok B, Holsboer F, Binder EB., Free PMC Articles: PMC3055621, PMC3055621 | 09/13/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Human variation in alcohol response is influenced by variation in neuronal signaling genes.
Joslyn G, Ravindranathan A, Brush G, Schuckit M, White RL. | 04/7/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | See all PubMed (2) articlesGlutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.
Giegling I, Drago A, Dolžan V, Plesničar BK, Schäfer M, Hartmann AM, Sander T, Toliat MR, Möller HJ, Stassen HH, Rujescu D, Serretti A. Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.
Perlis RH, Fijal B, Dharia S, Heinloth AN, Houston JP. | 04/7/2010 |
| Clinical trial of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.
Horstmann S, Lucae S, Menke A, Hennings JM, Ising M, Roeske D, Müller-Myhsok B, Holsboer F, Binder EB, Horstmann S, Lucae S, Menke A, Hennings JM, Ising M, Roeske D, Müller-Myhsok B, Holsboer F, Binder EB., Free PMC Articles: PMC3055621, PMC3055621 | 12/2/2009 |
| This report provides the first evidence that genetic variation in the GRIK4 gene modulates hippocampal function. | A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function.
Whalley HC, Pickard BS, McIntosh AM, Zuliani R, Johnstone EC, Blackwood DH, Lawrie SM, Muir WJ, Hall J. | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.
Arai S, Shibata H, Sakai M, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y. | 02/11/2009 |
| An insertion/deletion (indel) variant in the 3' untranslated region (3'UTR) of the GRIK4 gene in subjects carrying the protective bipolar disorder haplotype was found. | A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.
Pickard BS, Knight HM, Hamilton RS, Soares DC, Walker R, Boyd JK, Machell J, Maclean A, McGhee KA, Condie A, Porteous DJ, St Clair D, Davis I, Blackwood DH, Muir WJ, Pickard BS, Knight HM, Hamilton RS, Soares DC, Walker R, Boyd JK, Machell J, Maclean A, McGhee KA, Condie A, Porteous DJ, St Clair D, Davis I, Blackwood DH, Muir WJ., Free PMC Articles: PMC2567472, PMC2567472 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesCase-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.
Yosifova A, Mushiroda T, Stoianov D, Vazharova R, Dimova I, Karachanak S, Zaharieva I, Milanova V, Madjirova N, Gerdjikov I, Tolev T, Velkova S, Kirov G, Owen MJ, O'Donovan MC, Toncheva D, Nakamura Y. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.
Pickard BS, Knight HM, Hamilton RS, Soares DC, Walker R, Boyd JK, Machell J, Maclean A, McGhee KA, Condie A, Porteous DJ, St Clair D, Davis I, Blackwood DH, Muir WJ, Pickard BS, Knight HM, Hamilton RS, Soares DC, Walker R, Boyd JK, Machell J, Maclean A, McGhee KA, Condie A, Porteous DJ, St Clair D, Davis I, Blackwood DH, Muir WJ. No genetic association between polymorphisms in the kainate-type glutamate receptor gene, GRIK4, and schizophrenia in the Chinese population.
Li Z, He Z, Tang W, Tang R, Huang K, Xu Z, Xu Y, Li L, Li X, Feng G, He L, Shi Y. Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.
Shibata H, Aramaki T, Sakai M, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y. | 03/13/2008 |
| Cytogenetic and genetic findings provide molecular evidence for common etiologies for schizophrenia and and bipolar disorder and further support the 'glutamate hypothesis' of psychotic illness. | Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder.
Pickard BS, Malloy MP, Christoforou A, Thomson PA, Evans KL, Morris SW, Hampson M, Porteous DJ, Blackwood DH, Muir WJ. | 01/21/2010 |