| Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury. | Dysfunctional APPL1-Mediated Epigenetic Regulation in Diabetic Vascular Injury.
Du Y, Duan Y, Zhao J, Liu C, Zhang Z, Zhang J, Meng Z, Wang X, Lau WB, Xie D, Lopez BL, Christopher TA, Gao E, Koch WW, Liu H, Liu D, Ma XL, Gu G, Wang Y. | 11/27/2023 |
| LncRNA CEBPA-AS1 alleviates cerebral ischemia-reperfusion injury by sponging miR-340-5p regulating APPL1/LKB1/AMPK pathway. | LncRNA CEBPA-AS1 alleviates cerebral ischemia-reperfusion injury by sponging miR-340-5p regulating APPL1/LKB1/AMPK pathway.
Tu X, Zhang H, Chen S, Ding YH, Wu X, Liang R, Shi SS. | 01/15/2022 |
| PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway. | PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway.
Bai L, Yang J, Zhang H, Liao W, Cen Y., Free PMC Article | 12/11/2021 |
| APPL1 may be a key regulator of insulin resistance in skeletal muscle, and Resistance training may be an important physiological treatment increasing APPL1 expression, which is attenuated in T2 Diabetes. | Resistance training recovers attenuated APPL1 expression and improves insulin-induced Akt signal activation in skeletal muscle of type 2 diabetic rats.
Kido K, Ato S, Yokokawa T, Sato K, Fujita S. | 02/23/2019 |
| APPL1 gates PI3K activation at the plasma membrane upon long-term potentiation induction. | APPL1 gates long-term potentiation through its plekstrin homology domain.
Fernández-Monreal M, Sánchez-Castillo C, Esteban JA. | 08/5/2017 |
| AdipoR1 and the adaptor protein APPL1 mediated the protective effects of gAcrp. In addition, the function of adiponectin and phosphorylation of AMPK were prominently diminished by inhibition of PI3K. | AdipoR1/APPL1 potentiates the protective effects of globular adiponectin on angiotensin II-induced cardiac hypertrophy and fibrosis in neonatal rat atrial myocytes and fibroblasts.
Cao T, Gao Z, Gu L, Chen M, Yang B, Cao K, Huang H, Li M., Free PMC Article | 04/18/2015 |
| Adiponectin increased colocalization of actin and APPL1. | Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes.
Palanivel R, Ganguly R, Turdi S, Xu A, Sweeney G. | 11/22/2014 |
| a role of adiponectin-stimulated APPL1-AMPK signaling in cell migration in cardiac fibroblasts | Adiponectin mediated APPL1-AMPK signaling induces cell migration, MMP activation, and collagen remodeling in cardiac fibroblasts.
Dadson K, Chasiotis H, Wannaiampikul S, Tungtrongchitr R, Xu A, Sweeney G. | 10/4/2014 |
| In mesenteric resistance arteries downregulation of APPL1 is inhibited following antidiabetic treatment of diabetic fatty rats. | Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats.
Schmid PM, Resch M, Schach C, Birner C, Riegger GA, Luchner A, Endemann DH., Free PMC Article | 10/19/2013 |
| Hypoadiponectinemia induces APPL1 downregulation in the resistance vessels, contributing to the development of vascular insulin resistance in vascular endothelium in normotensive spontaneously hypertensive rats. | A novel mechanism for vascular insulin resistance in normotensive young SHRs: hypoadiponectinemia and resultant APPL1 downregulation.
Xing W, Yan W, Liu P, Ji L, Li Y, Sun L, Tao L, Zhang H, Gao F. | 07/6/2013 |
| APPL1 protein increases hepatic insulin sensitivity by potentiating insulin-mediated suppression of the gluconeogenic program. | APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.
Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A. | 12/14/2011 |
| hypoxia-reoxygenation -induced ROS generation and activation of the intrinsic apoptotic pathway was prevented by adiponectin via AdipoR1/APPL1 signaling and increased anti-oxidant potential | Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosis.
Park M, Youn B, Zheng XL, Wu D, Xu A, Sweeney G., Free PMC Article | 08/27/2011 |
| Data indicate that APPL1 promotes glucose disposal into skeletal muscle through activation of PI3-kinase pathway. Overexpression of APPL1 may be capable of partially ameliorating insulin resistance (as caused by a high fat diet) in skeletal muscle. | The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway.
Cleasby ME, Lau Q, Polkinghorne E, Patel SA, Leslie SJ, Turner N, Cooney GJ, Xu A, Kraegen EW., Free PMC Article | 08/27/2011 |
| Results indicate that APPL1 signaling through Akt and PAK is critical for spine and synaptic development and point to a role for APPL1 and its effectors in regulating cognitive function. | An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons.
Majumdar D, Nebhan CA, Hu L, Anderson B, Webb DJ., Free PMC Article | 06/18/2011 |