| The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer. | The promoting effects of Grin2d expression in tumorigenesis and the aggressiveness of esophageal cancer.
Wang LL, Li J, Xue H, Zhang L, Yu DY, Yang N, Yun WJ, Zhao MZ, Zheng HC. | 05/13/2024 |
| Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning. | Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.
Neumann A, Ohlei O, Küçükali F, Bos IJ, Timsina J, Vos S, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Scheltens P, Teunissen CE, Engelborghs S, Frisoni GB, Blin O, Richardson JC, Bordet R, Lleó A, Alcolea D, Popp J, Marsh TW, Gorijala P, Clark C, Peyratout G, Martinez-Lage P, Tainta M, Dobson RJB, Legido-Quigley C, Van Broeckhoven C, Tanzi RE, Ten Kate M, Lill CM, Barkhof F, Cruchaga C, Lovestone S, Streffer J, Zetterberg H, Visser PJ, Sleegers K, Bertram L, EMIF-AD & ADNI study group., Free PMC Article | 10/6/2023 |
| Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia. | Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia.
Vinnakota C, Hudson MR, Jones NC, Sundram S, Hill RA., Free PMC Article | 08/3/2023 |
| GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway. | GRIN2D knockdown suppresses the progression of lung adenocarcinoma by regulating the E2F signalling pathway.
Chen Z, Song Y, Li P, Gao W. | 05/17/2023 |
| Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs. | Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H., Free PMC Article | 12/10/2022 |
| MicroRNA-129-1-3p Represses the Progression of Triple-Negative Breast Cancer by Targeting the GRIN2D Gene. | MicroRNA-129-1-3p Represses the Progression of Triple-Negative Breast Cancer by Targeting the GRIN2D Gene.
Li Q, Gu Z, Tan Q, Ren L, Chen S., Free PMC Article | 04/2/2022 |
| GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons. | GluN2D-mediated excitatory drive onto medial prefrontal cortical PV+ fast-spiking inhibitory interneurons.
Garst-Orozco J, Malik R, Lanz TA, Weber ML, Xi H, Arion D, Enwright JF 3rd, Lewis DA, O'Donnell P, Sohal VS, Buhl DL., Free PMC Article | 08/22/2020 |
| we identified three patients with novel GRIN2D variants, providing the solid evidence that GRIN2D variants cause epileptic encephalopathy. | GRIN2D variants in three cases of developmental and epileptic encephalopathy.
Tsuchida N, Hamada K, Shiina M, Kato M, Kobayashi Y, Tohyama J, Kimura K, Hoshino K, Ganesan V, Teik KW, Nakashima M, Mitsuhashi S, Mizuguchi T, Takata A, Miyake N, Saitsu H, Ogata K, Miyatake S, Matsumoto N. | 11/16/2019 |
| ultra-rare variants with loss of function (frameshift, nonsense or splice site) in NMDARs genes like GRIN2C and GRIN2D may contribute to possible risk of schizophrenia | Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.
Yu Y, Lin Y, Takasaki Y, Wang C, Kimura H, Xing J, Ishizuka K, Toyama M, Kushima I, Mori D, Arioka Y, Uno Y, Shiino T, Nakamura Y, Okada T, Morikawa M, Ikeda M, Iwata N, Okahisa Y, Takaki M, Sakamoto S, Someya T, Egawa J, Usami M, Kodaira M, Yoshimi A, Oya-Ito T, Aleksic B, Ohno K, Ozaki N., Free PMC Article | 12/22/2018 |
| This study found that NMDAR activation, NR2D in particular, is involved in human fetal lung fibroblast proliferation and collagen production through a potential ERK1/2-mediated mechanism. | The excitotoxity of NMDA receptor NR2D subtype mediates human fetal lung fibroblasts proliferation and collagen production.
Wang M, Luo Z, Yue Y, Wang Y, Wu S, Cao C, Liao Z, Yu X, Yue S. | 07/21/2018 |
| High GRIN2D expression is associated with colorectal cancer. | Glutamate dependent NMDA receptor 2D is a novel angiogenic tumour endothelial marker in colorectal cancer.
Ferguson HJ, Wragg JW, Ward S, Heath VL, Ismail T, Bicknell R., Free PMC Article | 01/27/2018 |
| This study showed that the higher GluN2D mRNA level in healthy but not in depressed pregnant women as compared to non-pregnant individuals. | AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.
Bhandage AK, Jin Z, Hellgren C, Korol SV, Nowak K, Williamsson L, Sundström-Poromaa I, Birnir B. | 08/19/2017 |
| GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers | GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.
Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von Stülpnagel-Steinbeis C, Hu C, Kusumoto H, Hedrich UB, Elsen G, Hörtnagel K, Aizenman E, Lemke JR, Hakonarson H, Traynelis SF, Falk MJ., Free PMC Article | 05/27/2017 |
| After 7 days of chronic alcohol exposure, there are significant increases in mRNA expression of GRIN2D in cultured neurons derived from alcoholic subjects, but not in cultures from nonalcoholics. | Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro.
Lieberman R, Levine ES, Kranzler HR, Abreu C, Covault J., Free PMC Article | 07/13/2013 |
| Absence of truncating mutation in GRIN1 and GRIN2D genes in patients with autism spectrum disorder and schizophrenia and controls. | Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
Tarabeux J, Kebir O, Gauthier J, Hamdan FF, Xiong L, Piton A, Spiegelman D, Henrion É, Millet B, S2D team, Fathalli F, Joober R, Rapoport JL, DeLisi LE, Fombonne É, Mottron L, Forget-Dubois N, Boivin M, Michaud JL, Drapeau P, Lafrenière RG, Rouleau GA, Krebs MO., Free PMC Article | 04/6/2013 |
| In microsatellite instable and microsatellite and chromosomally stable cancers, CIMP and BRAF/KRAS mutations are similarly distributed indicating common mechanisms of tumor initiation or progression in the molecular pathogenesis. | [Chromosomal instability, microsatellite instability and CpG island methylator phenotype: roles in small intestinal carcinogenesis].
Bläker H, Warth A, Kloor M, Schirmacher P. | 03/24/2012 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article | 02/11/2009 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.
Arai S, Shibata H, Sakai M, Ninomiya H, Iwata N, Ozaki N, Fukumaki Y. | 02/11/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesNeurotransmission and bipolar disorder: a systematic family-based association study.
Shi J, Badner JA, Hattori E, Potash JB, Willour VL, McMahon FJ, Gershon ES, Liu C. Identification of single-nucleotide polymorphisms in the human N-methyl-D-aspartate receptor subunit NR2D gene, GRIN2D, and association study with schizophrenia.
Makino C, Shibata H, Ninomiya H, Tashiro N, Fukumaki Y. Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.
Williams NM, Bowen T, Spurlock G, Norton N, Williams HJ, Hoogendoorn B, Owen MJ, O'Donovan MC. | 03/13/2008 |
| data show that the NMDAR2D was specifically expressed in cultivated keratinocytes | Cultivated keratinocytes express N-methyl-D-aspartate receptors of the NMDAR2D type.
Fischer M, Fiedler E, Seidel C, Meiss F, Klapperstück T, Helmbold P, Dammann R. | 01/21/2010 |