| RACGAP1 is a pivotal gene in lung adenocarcinoma-associated membranous nephropathy: Based on comprehensive bioinformatics analysis and machine learning. | RACGAP1 is a pivotal gene in lung adenocarcinoma-associated membranous nephropathy: Based on comprehensive bioinformatics analysis and machine learning.
Xu Q, Li J, Zhuo L, Gao H, Yang Y, Li W. | 09/23/2024 |
| RACGAP1 promotes lung cancer cell proliferation through the PI3K/AKT signaling pathway. | RACGAP1 promotes lung cancer cell proliferation through the PI3K/AKT signaling pathway.
Xu Z, Wu S, Tu J, Wang M, Liang W, Cheng J, Guan J, Xu J., Free PMC Article | 05/21/2024 |
| RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2. | RACGAP1 drives proliferation, migration and invasion and suppresses autophagy of gastric cancer cells via inhibiting SIRT1/Mfn2.
Yan T, Lu G, Shang R, Hu J, Zhu C, Jin L. | 03/25/2024 |
| FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells. | FOXM1 transcriptional regulation of RacGAP1 activates the PI3K/AKT signaling pathway to promote the proliferation, migration, and invasion of cervical cancer cells.
Yao H, Li J, Zhou D, Pan X, Chu Y, Yin J. | 02/23/2024 |
| Oncogenic and immunological roles of RACGAP1 in pan-cancer and its potential value in nasopharyngeal carcinoma. | Oncogenic and immunological roles of RACGAP1 in pan-cancer and its potential value in nasopharyngeal carcinoma.
Zheng CS, Huang WM, Xia HM, Mi JL, Li YQ, Liang HQ, Zhou L, Lu ZX, Wu F. | 02/1/2024 |
| m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis. | m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis.
Tian Q, Mu Q, Liu S, Huang K, Tang Y, Zhang P, Zhao J, Shu C. | 01/30/2024 |
| RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness. | RACGAP1 promotes the progression and poor prognosis of lung adenocarcinoma through its effects on the cell cycle and tumor stemness.
Liu Y, Han T, Miao R, Zhou J, Guo J, Xu Z, Xing Y, Bai Y, Wu J, Hu D., Free PMC Article | 01/17/2024 |
| Racgap1 knockdown results in cells with multiple cilia due to cytokinesis failure. | Racgap1 knockdown results in cells with multiple cilia due to cytokinesis failure.
Basu B, Lake AVR, China B, Szymanska K, Wheway G, Bell S, Morrison E, Bond J, Johnson CA., Free PMC Article | 01/3/2024 |
| Mutations in the RACGAP1 gene cause autosomal recessive congenital dyserythropoietic anemia type III. | Mutations in the RACGAP1 gene cause autosomal recessive congenital dyserythropoietic anemia type III.
Hernández G, Romero-Cortadellas L, Ferrer-Cortès X, Venturi V, Dessy-Rodriguez M, Olivella M, Husami A, De Soto CP, Morales-Camacho RM, Villegas A, González-Fernández FA, Morado M, Kalfa TA, Quintana-Bustamante O, Pérez-Montero S, Tornador C, Segovia JC, Sánchez M., Free PMC Article | 02/11/2023 |
| Assessment of RACGAP1 as a Prognostic and Immunological Biomarker in Multiple Human Tumors: A Multiomics Analysis. | Assessment of RACGAP1 as a Prognostic and Immunological Biomarker in Multiple Human Tumors: A Multiomics Analysis.
Eid RA, Soltan MA, Eldeen MA, Shati AA, Dawood SA, Eissa M, Zaki MSA, Algahtani M, Theyab A, Abdel-Daim MM, Kim B., Free PMC Article | 12/10/2022 |
| Up-Regulation of RACGAP1 Promotes Progressions of Hepatocellular Carcinoma Regulated by GABPA via PI3K/AKT Pathway. | Up-Regulation of RACGAP1 Promotes Progressions of Hepatocellular Carcinoma Regulated by GABPA via PI3K/AKT Pathway.
Gu Y, Chen B, Guo D, Pan L, Luo X, Tang J, Yang W, Zhang Y, Zhang L, Huang J, Duan R, Wang Z., Free PMC Article | 08/27/2022 |
| LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2. | LncRNA PART1 Stimulates the Development of Ovarian Cancer by Up-regulating RACGAP1 and RRM2.
Li H, Lei Y, Li S, Li F, Lei J. | 08/13/2022 |
| RacGAP1 promotes the malignant progression of cervical cancer by regulating AP-1 via miR-192 and p-JNK. | RacGAP1 promotes the malignant progression of cervical cancer by regulating AP-1 via miR-192 and p-JNK.
Zhang T, Wang C, Wang K, Liang Y, Liu T, Feng L, Yang X., Free PMC Article | 07/23/2022 |
| RACGAP1 promotes proliferation and cell cycle progression by regulating CDC25C in cervical cancer cells. | RACGAP1 promotes proliferation and cell cycle progression by regulating CDC25C in cervical cancer cells.
Ruan X, Jiang J. | 06/11/2022 |
| EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer progression through inhibiting RACGAP1-mediated RAC1 inactivation. | EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer progression through inhibiting RACGAP1-mediated RAC1 inactivation.
Yin H, Zhang C, Wei Z, He W, Xu N, Xu Y, Li T, Ren K, Kuang Y, Zhu X, Yuan F, Yu H, Gou X., Free PMC Article | 03/26/2022 |
| Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis. | Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis.
Bian R, Dang W, Song X, Liu L, Jiang C, Yang Y, Li Y, Li L, Li X, Hu Y, Bao R, Liu Y., Free PMC Article | 03/26/2022 |
| RACGAP1 variants in a sporadic case of CDA III implicate the dysfunction of centralspindlin as the basis of the disease. | RACGAP1 variants in a sporadic case of CDA III implicate the dysfunction of centralspindlin as the basis of the disease.
Wontakal SN, Britto M, Zhang H, Han Y, Gao C, Tannenbaum S, Durham BH, Lee MT, An X, Mishima M., Free PMC Article | 03/19/2022 |
| RACGAP1 modulates ECT2-Dependent mitochondrial quality control to drive breast cancer metastasis. | RACGAP1 modulates ECT2-Dependent mitochondrial quality control to drive breast cancer metastasis.
Ren K, Zhou D, Wang M, Li E, Hou C, Su Y, Zou Q, Zhou P, Liu X. | 09/4/2021 |
| RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells. | RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.
Zhou W, Zhao S, Xu S, Sun Z, Liang Y, Ding X. | 01/23/2021 |
| upregulated in prostate cancer tissues | Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis.
Song ZY, Chao F, Zhuo Z, Ma Z, Li W, Chen G., Free PMC Article | 07/25/2020 |
| RACGAP1 plays a pivotal role in EC development, suggesting that it could be used as an indicator of prognosis in EC patients. | Rac GTPase-Activating Protein 1 (RACGAP1) as an Oncogenic Enhancer in Esophageal Carcinoma.
Yin C, Toiyama Y, Okugawa Y, Shigemori T, Yamamoto A, Ide S, Kitajima T, Fujikawa H, Yasuda H, Okita Y, Hiro J, Yoshiyama S, Ohi M, Araki T, Yao L, Kusunoki M. | 09/14/2019 |
| results support the view that CYK4 is a crucial regulator of Rac1 in adherent cells and that inhibition of Rac1-dependent effector pathways in anaphase is needed for cytokinesis | CYK4 inhibits Rac1-dependent PAK1 and ARHGEF7 effector pathways during cytokinesis.
Bastos RN, Penate X, Bates M, Hammond D, Barr FA., Free PMC Article | 09/7/2019 |
| RACGAP1 promotes proliferation of hepatocellular carcinoma cells by reducing activation of the Hippo and YAP pathways and promoting cytokinesis in coordination with nuclear basket protein, TPR. | Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis.
Yang XM, Cao XY, He P, Li J, Feng MX, Zhang YL, Zhang XL, Wang YH, Yang Q, Zhu L, Nie HZ, Jiang SH, Tian GA, Zhang XX, Liu Q, Ji J, Zhu X, Xia Q, Zhang ZG. | 10/27/2018 |
| The rs615382 variant disrupts the recombination signal binding protein with immunoglobulin kappa J binding site in Rac GTPase activating protein 1. Disruption of notch 1 mediated-repression of RACGAP1 may contribute to Prostate Cancer in African Americans. | Admixture Mapping Links RACGAP1 Regulation to Prostate Cancer in African Americans.
Wilson BD, Ricks-Santi LJ, Mason TE, Abbas M, Kittles RA, Dunston GM, Kanaan YM., Free PMC Article | 10/27/2018 |
| Study showed that a subset of epithelial ovarian cancer (EOC) patients have RacGAP1 overexpression which is associated with advanced tumor stages and poor clinical outcomes. Also, RacGAP1 can positively regulate the activation of RhoA and Erk proteins, thus up-enhance the migration and invasion process of EOC. | Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer.
Wang C, Wang W, Liu Y, Yong M, Yang Y, Zhou H., Free PMC Article | 01/27/2018 |