| Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by alpha-Synuclein. | Mitophagy Upregulation Occurs Early in the Neurodegenerative Process Mediated by α-Synuclein.
Hui S, George J, Kapadia M, Chau H, Bariring Z, Earnshaw R, Shafiq K, Kalia LV, Kalia SK., Free PMC Article | 10/30/2024 |
| Differential expression of alpha-synuclein in the hippocampus of SHR and SLA16 isogenic rat strains. | Differential expression of alpha-synuclein in the hippocampus of SHR and SLA16 isogenic rat strains.
De Barros Oliveira R, Anselmi M, Marchette RCN, Roversi K, Fadanni GP, De Carvalho LM, Damasceno S, Heinrich IA, Leal RB, Cavalli J, Moreira-Júnior RE, Godard ALB, Izídio GS. | 02/4/2024 |
| The toxicities of A30P and A53T alpha-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine. | The toxicities of A30P and A53T α-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine.
Ali A, Zhaliazka K, Dou T, Holman AP, Kurouski D., Free PMC Article | 01/9/2024 |
| Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer. | Upregulation of Parkinson's disease-associated protein alpha-synuclein suppresses tumorigenesis via interaction with mGluR5 and gamma-synuclein in liver cancer.
Yang HM, Cheng YZ, Hou TZ, Fan JK, Gu L, Zhang JN, Zhang H. | 08/9/2023 |
| VPS35 and alpha-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease. | VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease.
Chen X, Tsika E, Levine N, Moore DJ., Free PMC Article | 08/7/2023 |
| Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats. | Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats.
Wang Y, Miao Z, Xu C, Cai Y, Yang Y, Hu Y, Zhao M, Shao Y, Li Z, Chen J, Chen S, Wang L., Free PMC Article | 05/15/2023 |
| Intracellular Accumulation of alpha-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines. | Intracellular Accumulation of α-Synuclein Aggregates Promotes S-Nitrosylation of MAP1A Leading to Decreased NMDAR-Evoked Calcium Influx and Loss of Mature Synaptic Spines.
Hallam RD, Buchner-Duby B, Stykel MG, Coackley CL, Ryan SD., Free PMC Article | 01/14/2023 |
| alpha-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25alpha. | α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α.
Borland H, Rasmussen I, Bjerregaard-Andersen K, Rasmussen M, Olsen A, Vilhardt F., Free PMC Article | 12/3/2022 |
| Lateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioral tests. | Lateralized deficits after unilateral AAV-vector based overexpression of alpha-synuclein in the midbrain of rats on drug-free behavioral tests.
Gubinelli F, Cazzolla G, Negrini M, Kulacz I, Mehrdadian A, Tomasello G, Venuti C, Sarauskyte L, Jacobs F, Manfredsson FP, Davidsson M, Heuer A. | 06/25/2022 |
| Pathogenic Mechanisms of Cytosolic and Membrane-Enriched alpha-Synuclein Converge on Fatty Acid Homeostasis. | Pathogenic Mechanisms of Cytosolic and Membrane-Enriched α-Synuclein Converge on Fatty Acid Homeostasis.
Tripathi A, Alnakhala H, Terry-Kantor E, Newman A, Liu L, Imberdis T, Fanning S, Nuber S, Ramalingam N, Selkoe D, Dettmer U., Free PMC Article | 05/7/2022 |
| Impact of monomeric and aggregated wild-type and A30P/A53T double-mutant alpha-synuclein on antioxidant mechanism and glutamate metabolic profile of cultured astrocytes. | Impact of monomeric and aggregated wild-type and A30P/A53T double-mutant α-synuclein on antioxidant mechanism and glutamate metabolic profile of cultured astrocytes.
Raj A, Kaushal A, Datta I. | 04/9/2022 |
| Reduction of tyrosine hydroxylase expression and increase of alpha-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia. | Reduction of tyrosine hydroxylase expression and increase of α-synuclein in the substantia nigra in a rat model of benign prostatic hyperplasia.
Seo MH, Jin BR, Kim HJ, An HJ, Yeo S. | 03/19/2022 |
| Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome. | Alpha-synuclein aggresomes inhibit ciliogenesis and multiple functions of the centrosome.
Iqbal A, Baldrighi M, Murdoch JN, Fleming A, Wilkinson CJ., Free PMC Article | 10/16/2021 |
| Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons. | Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons.
Ramalingam N, Dettmer U., Free PMC Article | 08/28/2021 |
| Synapsin Condensates Recruit alpha-Synuclein. | Synapsin Condensates Recruit alpha-Synuclein.
Hoffmann C, Sansevrino R, Morabito G, Logan C, Vabulas RM, Ulusoy A, Ganzella M, Milovanovic D. | 08/21/2021 |
| Differential Regional Responses in Soluble Monomeric Alpha Synuclein Abundance Following Traumatic Brain Injury. | Differential Regional Responses in Soluble Monomeric Alpha Synuclein Abundance Following Traumatic Brain Injury.
Carlson SW, Yan HQ, Li Y, Henchir J, Ma X, Young MS, Ikonomovic MD, Dixon CE., Free PMC Article | 08/7/2021 |
| Intramitochondrial proteostasis is directly coupled to alpha-synuclein and amyloid beta1-42 pathologies. | Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies.
Lautenschläger J, Wagner-Valladolid S, Stephens AD, Fernández-Villegas A, Hockings C, Mishra A, Manton JD, Fantham MJ, Lu M, Rees EJ, Kaminski CF, Kaminski Schierle GS., Free PMC Article | 01/16/2021 |
| Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by alpha-synuclein. | Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein.
McKinnon C, De Snoo ML, Gondard E, Neudorfer C, Chau H, Ngana SG, O'Hara DM, Brotchie JM, Koprich JB, Lozano AM, Kalia LV, Kalia SK., Free PMC Article | 12/26/2020 |
| alpha-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease. | α-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease.
Dehghani Z, Meratan AA, Saboury AA, Nemat-Gorgani M. | 08/22/2020 |
| alpha-synuclein oligomers are conformationally distinct but share common epitopes and the ability to impair long-term potentiation | Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation.
van Diggelen F, Hrle D, Apetri M, Christiansen G, Rammes G, Tepper A, Otzen DE., Free PMC Article | 12/28/2019 |
| DOR attenuates the formation of toxic alpha-synuclein oligomers through the phos-CREB pathway under hypoxic conditions, and through TORC1/SIK1/CREB pathways in the conditions of alpha-synuclein overexpression and mutation. | δ-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or α-Synuclein Overexpression/Mutation Through Dual Signaling Pathways.
Chen T, Wang Q, Chao D, Xia TC, Sheng S, Li ZR, Zhao JN, Wen GQ, Ding G, Xia Y. | 08/17/2019 |
| Our findings indicate that alphaSyn facilitates to form short, mobile tMTs that play an important role in the axonal transport. This unexpected and intriguing discovery related to axonal transport provides new insight on the pathogenesis of PD. | Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport.
Toba S, Jin M, Yamada M, Kumamoto K, Matsumoto S, Yasunaga T, Fukunaga Y, Miyazawa A, Fujita S, Itoh K, Fushiki S, Kojima H, Wanibuchi H, Arai Y, Nagai T, Hirotsune S., Free PMC Article | 07/13/2019 |
| This work shows that wild type alpha-synuclein interacts with isolated mitochondria and translocates into the mitochondrial matrix. | Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment.
Martínez JH, Fuentes F, Vanasco V, Alvarez S, Alaimo A, Cassina A, Coluccio Leskow F, Velazquez F. | 06/29/2019 |
| In rotenone-mediated dopaminergic cell models, the enhancement of p75 contributed to alpha-syn expression. The elevation of p75 also boosts the expression of ubiquitin ligase absentia homolog (siAH) and nuclear p65. Thus, p75 may enhance alpha-syn expression by promoting the activation of siAH, which is associated with ubiquitination. | P75 Involved in the Ubiquitination of α-synuclein in Rotenone-based Parkinson's Disease Models.
Chen Y, Hou Y, Yang J, Du R, Chen C, Chen F, Wang H, Ge R, Chen J. | 03/30/2019 |
| ur findings suggest the possibility of endogenous alpha-synuclein accumulation in oligodendrocyte precursor cells that contributes to glial cytoplasmic inclusions formation and perturbation of neuronal/glial support in multiple system atrophy brains. | Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy.
Kaji S, Maki T, Kinoshita H, Uemura N, Ayaki T, Kawamoto Y, Furuta T, Urushitani M, Hasegawa M, Kinoshita Y, Ono Y, Mao X, Quach TH, Iwai K, Dawson VL, Dawson TM, Takahashi R., Free PMC Article | 01/19/2019 |