| GRP/GRPR enhances alcohol-associated liver injury through the IRF1-mediated Caspase-1 inflammasome and NOX2-dependent ROS pathway. | GRP/GRPR enhances alcohol-associated liver injury through the IRF1-mediated Caspase-1 inflammasome and NOX2-dependent ROS pathway.
Li H, Chen X, Xu J, Zhu L, Li C, Sun X, Li X, Guo J, Li J, Wang S, He Y, Wang H, Huang C, Meng XM, Li J. | 01/26/2024 |
| Microglia-neuron interactions promote chronic itch via the NLRP3-IL-1beta-GRPR axis. | Microglia-neuron interactions promote chronic itch via the NLRP3-IL-1β-GRPR axis.
Liu X, Wang Y, Zeng Y, Wang D, Wen Y, Fan L, He Y, Zhang J, Sun W, Liu Y, Tao A. | 06/13/2023 |
| Novel Gastrin-Releasing Peptide Receptor Targeted Near-Infrared Fluorescence Dye for Image-Guided Surgery of Prostate Cancer. | Novel Gastrin-Releasing Peptide Receptor Targeted Near-Infrared Fluorescence Dye for Image-Guided Surgery of Prostate Cancer.
Pagoto A, Garello F, Marini GM, Tripepi M, Arena F, Bardini P, Stefania R, Lanzardo S, Valbusa G, Porpiglia F, Manfredi M, Aime S, Terreno E. | 01/23/2021 |
| GRP/GRP-R signaling activation contributes to castration-resistant prostate cancer progression | Activation of GRP/GRP-R signaling contributes to castration-resistant prostate cancer progression.
Qiao J, Grabowska MM, Forestier-Roman IS, Mirosevich J, Case TC, Chung DH, Cates JM, Matusik RJ, Manning HC, Jin R., Free PMC Article | 04/7/2018 |
| Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters | Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters: A Study of 1,432 Primary Tumors.
Morgat C, MacGrogan G, Brouste V, Vélasco V, Sévenet N, Bonnefoi H, Fernandez P, Debled M, Hindié E. | 10/7/2017 |
| Our results suggest that, similar to what happens in neutrophils, gastrin-releasing peptide is a migratory, rather than a proliferative, stimulus, for non-small cell lung carcinoma cells, indicating a putative role for gastrin-releasing peptide and gastrin-releasing peptide receptor in metastasis | Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species-dependent migration in lung adenocarcinoma cells.
Jaeger N, Czepielewski RS, Bagatini M, Porto BN, Bonorino C. | 04/8/2017 |
| GRP-R regulates glucose metabolism in neuroblastoma by modulating HIF-1alpha, PDK4 and PDP2. | Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells.
Rellinger EJ, Romain C, Choi S, Qiao J, Chung DH., Free PMC Article | 06/20/2015 |
| BBS caused a significant increase in Shh gene transcription and protein secretion that was dependent on BBS-induced GPCR/Galphaq-//Rho mediated activation of nuclear factor kappaB (NFkappaB), which can stimulate a NF-kappaB response element in the Shh gene promoter | Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma.
Castellone MD, Laukkanen MO, Teramoto H, Bellelli R, Alì G, Fontanini G, Santoro M, Gutkind JS., Free PMC Article | 06/6/2015 |
| No association of 16 GRP and 7 GRPR variants were found with agoraphobia with/without panic disorder. | Analysis of gastrin-releasing peptide gene and gastrin-releasing peptide receptor gene in patients with agoraphobia.
Zimmermann K, Görgens H, Bräuer D, Einsle F, Noack B, von Kannen S, Grossmann M, Hoyer J, Strobel A, Köllner V, Weidner K, Ziegler A, Hemmelmann C, Schackert HK. | 05/16/2015 |
| GRPR is highly expressed in epidermoid carcinoma of the anal canal, suggesting this receptor might have a role in anal carcinogenesis. | Expression of gastrin-releasing peptide receptor in epidermoid carcinoma of the anal canal.
Martins FF, Contu PC, Meurer L, Schwartsmann G, Damin DC. | 03/21/2015 |
| a key mechanism for GRPR-regulated colon cancer cell migration through the Galpha13-PRG-RhoA-ROCK pathway. | Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.
Patel M, Kawano T, Suzuki N, Hamakubo T, Karginov AV, Kozasa T., Free PMC Article | 10/4/2014 |
| GRPR expression was more pronounced in an advanced-stage lung cancer | Gastrin-releasing peptide receptor expression in lung cancer.
Mattei J, Achcar RD, Cano CH, Macedo BR, Meurer L, Batlle BS, Groshong SD, Kulczynski JM, Roesler R, Dal Lago L, Brunetto AT, Schwartsmann G. | 02/22/2014 |
| integrin ss1 subunit critically regulates GRP-R-mediated neuroblastoma cell migration and invasion | Integrin β1 is critical for gastrin-releasing peptide receptor-mediated neuroblastoma cell migration and invasion.
Lee S, Qiao J, Paul P, Chung DH., Free PMC Article | 10/26/2013 |
| Elevated buccal GRPR espression was significantly associated with squamous cell carcinoma of the head and neck. | Elevated gastrin-releasing peptide receptor mRNA expression in buccal mucosa: association with head and neck squamous cell carcinoma.
Egloff AM, Liu X, Davis AL, Trevelline BK, Vuga M, Siegfried JM, Grandis JR., Free PMC Article | 08/10/2013 |
| These findings highlight the role of GRPR signaling in sepsis outcome. | Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling.
Petronilho F, Vuolo F, Galant LS, Constantino L, Tomasi CD, Giombelli VR, de Souza CT, da Silva S, Barbeiro DF, Soriano FG, Streck EL, Ritter C, Zanotto-Filho A, Pasquali MA, Gelain DP, Rybarczyk-Filho JL, Moreira JC, Block NL, Roesler R, Schwartsmann G, Schally AV, Dal-Pizzol F., Free PMC Article | 05/11/2013 |
| Protein kinase C is critically responsible for rapid VEGF secretion by gastrin-releasing peptide receptor signaling in neuroblastoma cells | Protein kinase C regulates bombesin-induced rapid VEGF secretion in neuroblastoma cells.
Schlegel C, Paul P, Lee S, Kim KW, Colon N, Qiao J, Chung DH., Free PMC Article | 03/9/2013 |
| Tonic stretch of human myometrium increases contractility and stimulates the expression of a known smooth muscle stimulatory agonist, GRP. GRP receptor antagonists attenuate the effect of stretch. | Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility.
Tattersall M, Cordeaux Y, Charnock-Jones DS, Smith GC., Free PMC Article | 11/17/2012 |
| High GRPR is associated with prostate carcinoma. | Immunohistochemical analysis of gastrin-releasing peptide receptor (GRPR) and possible regulation by estrogen receptor βcx in human prostate carcinoma.
Nagasaki S, Nakamura Y, Maekawa T, Akahira J, Miki Y, Suzuki T, Ishidoya S, Arai Y, Sasano H. | 07/21/2012 |
| Bronchial gastrin-releasing peptide receptor expression was significantly associated with lung cancer in a multivariable logistic regression model adjusted for age, sex, smoking status and pulmonary function. Lung cancer risk was not modified by sex. | Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study.
Egloff AM, Gaither Davis A, Shuai Y, Land S, Pilewski JM, Luketich JD, Landreneau R, Miller YE, Grandis JR, Siegfried JM., Free PMC Article | 06/23/2012 |
| Concomitant vascular GRP-receptor and VEGF-receptor expression in human tumors provides molecular basis for dual targeting of tumoral vasculature. | Concomitant vascular GRP-receptor and VEGF-receptor expression in human tumors: molecular basis for dual targeting of tumoral vasculature.
Reubi JC, Fleischmann A, Waser B, Rehmann R. | 11/12/2011 |
| GRP promotes the growth of HepG2 cells through interaction with GRPR co-expressed in tumor cells, and subsequently activates MAPK/ERK1/2 via EGFR-independent mechanisms. | Gastrin-releasing peptide promotes the growth of HepG2 cells via EGFR-independent ERK1/2 activation.
Li X, Lv Y, Yuan A, Yi S, Ma Y, Li Z. | 11/13/2010 |
| This study is the first to confirm the presence of gastrin-releasing peptide receptor in human glioma specimens and normal human neurons. | Gastrin-releasing peptide receptor content in human glioma and normal brain.
Flores DG, Meurer L, Uberti AF, Macedo BR, Lenz G, Brunetto AL, Schwartsmann G, Roesler R. | 07/26/2010 |
| The results suggest that brain-derived neurotrophic factor/TrkB and cAMP phosphodiesterase-4, but not the gastrin-releasing peptide receptor, regulate the viability of medulloblastoma cells. | BDNF and PDE4, but not the GRPR, regulate viability of human medulloblastoma cells.
Schmidt AL, de Farias CB, Abujamra AL, Kapczinski F, Schwartsmann G, Brunetto AL, Roesler R. | 05/10/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q., Free PMC Article | 04/7/2010 |
| In MDA-MB-231 breast cancer cells, GRP-R and EGF-R synergize to regulate cell migration and IL-8 expression, but not cell proliferation. | Gastrin-releasing peptide receptor in breast cancer mediates cellular migration and interleukin-8 expression.
Chao C, Ives K, Hellmich HL, Townsend CM Jr, Hellmich MR., Free PMC Article | 01/21/2010 |