| Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model. | Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III Collagen Expression via Suppression of TGF-β and p-Smad 2/3 Pathway in Keloid Fibroblasts and Rat Incisional Model.
Kim SH, Oh JM, Roh H, Lee KW, Lee JH, Lee WJ., | 09/30/2024 |
| SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-beta1/smad2/3 signalling pathway. | SIRT3 sulfhydration using hydrogen sulfide inhibited angiotensin II-induced atrial fibrosis and vulnerability to atrial fibrillation via suppression of the TGF-β1/smad2/3 signalling pathway.
Hu HJ, Wang XH, Zhang ZZ, Ou Y, Ning ZH, Yang JY, Huang H, Tang HF, Jiang ZS. | 09/23/2024 |
| MicroRNA-499-5p inhibits transforming growth factor-beta1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFbeta-R1. | MicroRNA-499-5p inhibits transforming growth factor-β1-induced Smad2 signaling pathway and suppresses fibroblast proliferation and collagen synthesis in rat by targeting TGFβ-R1.
Zhao Q, Yang W, Li X, Yuan H, Guo J, Wang Y, Shan Z., Free PMC Article | 12/15/2023 |
| TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cellsdagger. | TGF-β1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cells†.
Ma B, Qiao H, Guo Y, Wei J, Yang Q, Feng X, Li Z. | 05/17/2023 |
| Candida albicans-induced activation of the TGF-beta/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion. | Candida albicans-induced activation of the TGF-β/Smad pathway and upregulation of IL-6 may contribute to intrauterine adhesion.
Zhao X, Sun D, Zhang A, Huang H, Li Y, Xu D., Free PMC Article | 02/13/2023 |
| beta-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs. | β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs.
Ibrahim S, Johnson M, Stephens CH, Xu J, Moore R, Mariani A, Contreras C, Syed F, Mirmira RG, Anderson RM, Sims EK., Free PMC Article | 03/26/2022 |
| Reduction of Smad2 caused by oxidative stress leads to necrotic death of hypertrophic chondrocytes associated with an endemic osteoarthritis. | Reduction of Smad2 caused by oxidative stress leads to necrotic death of hypertrophic chondrocytes associated with an endemic osteoarthritis.
He Y, Fan L, Aaron N, Feng Y, Fang Q, Zhang Y, Zhang D, Wang H, Ma T, Sun J, Chen J. | 02/26/2022 |
| Astragaloside IV alleviates silicainduced pulmonary fibrosis via inactivation of the TGFbeta1/Smad2/3 signaling pathway. | Astragaloside IV alleviates silica‑induced pulmonary fibrosis via inactivation of the TGF‑β1/Smad2/3 signaling pathway.
Li N, Wu K, Feng F, Wang L, Zhou X, Wang W., Free PMC Article | 07/17/2021 |
| Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-beta1/Smad2 pathway in a rat model of type 1 diabetes. | Islet transplantation ameliorates diabetes-induced testicular interstitial fibrosis and is associated with inhibition of TGF-β1/Smad2 pathway in a rat model of type 1 diabetes.
Zheng YC, Feng YL, Wang YH, Kong LJ, Zhou MS, Wu MM, Liu CY, Weng HC, Wang HW., Free PMC Article | 05/8/2021 |
| Resistance training-induced muscle hypertrophy is mediated by TGF-beta1-Smad signaling pathway in male Wistar rats. | Resistance training-induced muscle hypertrophy is mediated by TGF-β1-Smad signaling pathway in male Wistar rats.
Nikooie R, Jafari-Sardoie S, Sheibani V, Nejadvaziri Chatroudi A. | 03/13/2021 |
| Effect of miR-9 on myocardial fibrosis in rats via TGF-beta1/Smads signaling pathway. | Effect of miR-9 on myocardial fibrosis in rats via TGF-β1/Smads signaling pathway.
Jin X, Yu LL, Yu CX. | 12/12/2020 |
| Smad3 could inhibit SnoN expression and increase extracellular matrix deposition in NRK52E cells, to promote high glucose-induced renal tubular fibrosis. | Smad2 and Smad3 play antagonistic roles in high glucose-induced renal tubular fibrosis via the regulation of SnoN.
Wang Y, Zhang X, Mao Y, Liang L, Liu L, Peng W, Liu H, Xiao Y, Zhang Y, Zhang F, Shi M, Liu L, Guo B. | 07/25/2020 |
| The current study demonstrated that the suppression of miR-143-3p contributed to the anti-fibrosis effect of atorvastatin on myocardial tissues, which subsequently inhibited Smad2-mediated production of collagens. | Suppression of miR-143-3p contributes to the anti-fibrosis effect of atorvastatin on myocardial tissues via the modulation of Smad2 activity.
Yu B, Yu M, Zhang H, Xie D, Nie W, Shi K. | 07/18/2020 |
| MicroRNA-101 protects bladder of bladder outlet obstruction from hypoxia-induced fibrosis by attenuating TGF-beta-smad2/3 signaling. | MicroRNA-101 protects bladder of BOO from hypoxia-induced fibrosis by attenuating TGF-β-smad2/3 signaling.
Wang N, Duan L, Ding J, Cao Q, Qian S, Shen H, Qi J. | 01/18/2020 |
| findings demonstrate that KGF-1 promotes fibroblast contraction and accelerates wound contraction via the TGF-beta1/Smad signaling pathway in a double-paracrine manner. | KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner.
Peng Y, Wu S, Tang Q, Li S, Peng C., Free PMC Article | 12/14/2019 |
| TRPM7 depletion inhibited Ang II-induced p-Smad2 expression and collagen synthesis in CFs, whereas increased TRPM7 expression did the opposite. SAN fibrosis is regulated by the Ang II/TRPM7/Smad pathway in SSS, indicating that TRPM7 is a potential target for SAN fibrosis therapy in SSS. | TRPM7 regulates angiotensin II-induced sinoatrial node fibrosis in sick sinus syndrome rats by mediating Smad signaling.
Zhong H, Wang T, Lian G, Xu C, Wang H, Xie L., Free PMC Article | 10/20/2018 |
| the expression of CTGF, TGF-beta1 and p-SNAD2/3 is tissue-specific and stage-specific, and indicate a regulatory role for a TGF-beta1-SMAD2/3-CTGF signaling pathway in amelogenesis, dentinogenesis and formation of junctional epithelium | Immunolocalization of connective tissue growth factor, transforming growth factor-beta1 and phosphorylated-SMAD2/3 during the postnatal tooth development and formation of junctional epithelium.
Li S, Pan Y. | 09/1/2018 |
| cigarette smoke-induced upregulation of TGF-b1/Smad pathway components, including TGF-b1, TGF-bR1, phospho-Smad2, and phospho-Smad3, was also inhibited by ginsenoside Rg1. Additionally, ginsenoside Rg1 mimicked the effect of SB525334, a TGF-betaR1-Smad2/3 inhibitor, on suppression of EMT in CSE-induced HBE cells | Ginsenoside Rg1 Attenuates Cigarette Smoke-Induced Pulmonary Epithelial-Mesenchymal Transition via Inhibition of the TGF-β1/Smad Pathway.
Guan S, Xu W, Han F, Gu W, Song L, Ye W, Liu Q, Guo X., Free PMC Article | 06/23/2018 |
| Studied the effects of herbal compound 861 on transforming growth factor beta1 (TGF-beta1)/Sma and Mad-related proteins (Smad)/Ski-related novel protein N (SnoN) signal pathway in a rat hepatic fibrosis disease model. | Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF-β1/Smad/SnoN pathway in bile duct-ligated rats.
Chi C, Liu XY, Hou F, Yu XZ, Li CY, Cui LJ, Liu RX, Yin CH., Free PMC Article | 03/3/2018 |
| Lastly, the SENP1 knockdown HSC-T6 cells were successfully constructed, while the silence of SENP1 down-regulated the protein expression of alpha-SMA and SMAD2. In conclusion, this study provided a new regulation mechanism about the liver fibrosis process. | SENP1 attenuates the liver fibrosis through down-regulating the expression of SMAD2.
Wu L, Qiu W, Sun J, Wang J. | 12/30/2017 |
| results revealed that NaNO2 significantly increased serum tumor necrosis factor-alpha, C-reactive protein, heat shock proteins-70, vascular endothelial growth factor, and Interleukin 6. Moreover, transforming growth factor-beta, hypoxia-inducible factor, Smad-2, Protein Kinase B (AKT), and Bax were overexpressed, whereas Bcl2 protein was downregulated compared with the normoxic group. | Downregulation of HIF1-α, Smad-2, AKT, and Bax gene expression in sodium nitrite-induced lung injury via some antioxidants.
Kadry MO, Ali HM. | 12/23/2017 |
| hypoxia significantly decreased hemoglobin concentration, while increased expressions of HIF, Bax, Smad-2, TGF-beta, and AKT. | Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-α, TGF-β, Smad-2, and AKT pathways.
Al-Rasheed NM, Fadda LM, Attia HA, Ali HM, Al-Rasheed NM. | 12/16/2017 |
| exposure to hyperoxia altered the balance between TGF-beta-ALK1-Smad1/5 and TGF-beta-ALK5-Smad2/3 pathways in pulmonary endothelial cells, which may ultimately lead to the development of BPD. | Alteration of TGF-β-ALK-Smad signaling in hyperoxia-induced bronchopulmonary dysplasia model of newborn rats.
Jin M, Lee J, Lee KY, Jin Z, Pak JH, Kim HS. | 12/2/2017 |
| Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation. | Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation.
Wang H, Liu S, Liu S, Wei W, Zhou X, Lin F, Wang J, Chen J, Zhang G, Pang Y., Free PMC Article | 09/23/2017 |
| Both the in vitro and in vivo results clearly showed that, morin by acting on Hippo/Yap and TGF-beta1/Smad pathways, ameliorated experimental liver fibrosis, indicating that morin has potential for effective treatment of liver fibrosis. | Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling.
Perumal N, Perumal M, Halagowder D, Sivasithamparam N. | 09/16/2017 |