| Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats. | Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats.
Xu L, Yang L, Wu Y, Wan X, Tang X, Xu Y, Chen Q, Liu Y, Liu S., Free PMC Article | 03/24/2023 |
| Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction. | Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction.
Ma W, Wang X, Wang C, Gong M, Ren P., Free PMC Article | 03/20/2021 |
| MiRNA-221 regulates proliferation, apoptosis and insulin secretion in islet beta cells through targeting PAK1, thus protecting gestational diabetes mellitus -induced islet dysfunction in a rat model | MiRNA-221 protects islet β cell function in gestational diabetes mellitus by targeting PAK1.
Zhao H, Tao S. | 06/27/2020 |
| These results expand the model of insulin-stimulated glucose uptake in skeletal muscle cells by implicating p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WASP-cortactin-mediated actin polymerization and GLUT4 vesicle translocation. | The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells.
Tunduguru R, Zhang J, Aslamy A, Salunkhe VA, Brozinick JT, Elmendorf JS, Thurmond DC., Free PMC Article | 11/3/2018 |
| the oxidative stress-induced down-regulation of PAK1 activity could be involved in the loss of mesencephalic dopaminergic neurons. | Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons.
Kim H, Oh JY, Choi SL, Nam YJ, Jo A, Kwon A, Shin EY, Kim EG, Kim HK., Free PMC Article | 11/11/2017 |
| PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases. | Protein kinase D1 (PKD1) phosphorylation on Ser(203) by type I p21-activated kinase (PAK) regulates PKD1 localization.
Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E., Free PMC Article | 06/24/2017 |
| The spinal GTP-Rac1-PAK-ERK/p38MAPK signalling pathway is involved in both the development and maintenance of peripheral inflammatory pain and can be used as a potential molecular target for developing a novel therapeutic strategy for clinical pain | Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection.
Wang Y, Lu YF, Li CL, Sun W, Li Z, Wang RR, He T, Yang F, Yang Y, Wang XL, Guan SM, Chen J., Free PMC Article | 12/17/2016 |
| Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons. | Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity.
Ding Y, Li Y, Lu L, Zhang R, Zeng L, Wang L, Zhang X., Free PMC Article | 07/2/2016 |
| Data show that Smad3 protein transcriptional activation of E3 ubiquitin Llgase FBXO32 under stress is p21-activated kinase 1 Pak1 dependent in neonatal cardiomyocytes. | Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32.
Tsui H, Zi M, Wang S, Chowdhury SK, Prehar S, Liang Q, Cartwright EJ, Lei M, Liu W, Wang X. | 04/9/2016 |
| Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1. | Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1.
Kameritsch P, Kiemer F, Beck H, Pohl U, Pogoda K. | 12/19/2015 |
| Describe here an invadopodia disassembly model, where a signalling axis involving TrioGEF, Rac1, Pak1, and phosphorylation of cortactin, causes invadopodia dissolution. | A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly.
Moshfegh Y, Bravo-Cordero JJ, Miskolci V, Condeelis J, Hodgson L., Free PMC Article | 08/9/2014 |
| Shootin1 is located at a critical interface, transducing a chemical signal into traction forces for axon outgrowth. A chemoattractant, netrin-1, positively regulates traction forces at axonal growth cones via Pak1-mediated shootin1 phosphorylation. | Conversion of a signal into forces for axon outgrowth through Pak1-mediated shootin1 phosphorylation.
Toriyama M, Kozawa S, Sakumura Y, Inagaki N. | 09/21/2013 |
| Data suggest that neuroimmune modulation following traumatic stress is mediated by c-Src-mediated enhancement of miRNA222 expression and downregulation of PAK1, which in turn impairs signaling via IL-1beta/IL1-RI, leading to immunosuppression. | Neuroimmune modulation following traumatic stress in rats: evidence for an immunoregulatory cascade mediated by c-Src, miRNA222 and PAK1.
Zhao H, Yao R, Cao X, Wu G., Free PMC Article | 04/21/2012 |
| Pak1 is a novel antihypertrophic regulator, and it may be a potential therapeutic target for the treatment of cardiac hypertrophy and heart failure. | Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.
Liu W, Zi M, Naumann R, Ulm S, Jin J, Taglieri DM, Prehar S, Gui J, Tsui H, Xiao RP, Neyses L, Solaro RJ, Ke Y, Cartwright EJ, Lei M, Wang X., Free PMC Article | 02/11/2012 |
| also identify the gene encoding the protein kinase Pak1, which acts locally in neuronal processes to induce polarity, as a critical direct target gene of the FOXO transcription factors | A FOXO-Pak1 transcriptional pathway controls neuronal polarity.
de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A, Bonni A., Free PMC Article | 05/3/2010 |
| These data suggest that neuronal activity regulates spine formation, in part, by increasing miR132 transcription, which in turn activates a Rac1-Pak actin remodeling pathway. | An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling.
Impey S, Davare M, Lesiak A, Fortin D, Ando H, Varlamova O, Obrietan K, Soderling TR, Goodman RH, Wayman GA., Free PMC Article | 05/3/2010 |
| Data show that PAK1 was activated in neointima of the carotid artery after balloon injury. | p21-activated kinase 1 participates in vascular remodeling in vitro and in vivo.
Hinoki A, Kimura K, Higuchi S, Eguchi K, Takaguri A, Ishimaru K, Frank GD, Gerthoffer WT, Sommerville LJ, Autieri MV, Eguchi S., Free PMC Article | 01/25/2010 |
| a model for the complex and accurate regulation of PAK1 kinase in vivo at cell protrusions. | Dissecting activation of the PAK1 kinase at protrusions in living cells.
Parrini MC, Camonis J, Matsuda M, de Gunzburg J., Free PMC Article | 01/21/2010 |
| Report role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis. | A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
Wang D, Paria BC, Zhang Q, Karpurapu M, Li Q, Gerthoffer WT, Nakaoka Y, Rao GN., Free PMC Article | 01/21/2010 |
| While PAK1 and PAK3 share distinct roles in the regulation of spine morphogenesis, their activity may overlap, allowing compensation of PAK3 deficit by PAK1. | Distinct, but compensatory roles of PAK1 and PAK3 in spine morphogenesis.
Boda B, Jourdain L, Muller D. | 01/21/2010 |
| Abnormal proliferation in rat and human kidney epithelial cells expressing mutant human polycystin-2 appears to be independent of STAT-1/p21. | Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.
Felekkis KN, Koupepidou P, Kastanos E, Witzgall R, Bai CX, Li L, Tsiokas L, Gretz N, Deltas C., Free PMC Article | 01/21/2010 |
| 1) PAK plays a required role in hyperosmotic signaling through the PI3K/pTEN/Cdc42/PP2Calpha/p38 pathway, and 2) PAK and PP2Calpha modulate the effects of this pathway on focal adhesion dynamics. | PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.
Chan PM, Lim L, Manser E., Free PMC Article | 01/21/2010 |
| in intestinal epithelial cells, Ang II-dependent activation of the COX-2 promoter is mediated primarily through Gq/11 signaling via a PAK/MKK6/p38beta/CREB signaling cascade | COX-2 promoter activation by AT1R-Gq-PAK-p38beta signaling in intestinal epithelial cells.
Pham H, Vincenti R, Slice LW. | 01/21/2010 |
| p21-activated kinase-aberrant activation and translocation may have a role in Alzheimer disease pathogenesis | p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis.
Ma QL, Yang F, Calon F, Ubeda OJ, Hansen JE, Weisbart RH, Beech W, Frautschy SA, Cole GM., Free PMC Article | 01/21/2010 |
| These results connect two important regulators of cellular physiological functions and provide a potential mechanism for Pak1 signaling in cardiomyocytes. | Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes.
Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, Liang Q., Free PMC Article | 01/21/2010 |