| MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca(2+) release in hypertrophic rat cardiomyocytes. | MCU overexpression evokes disparate dose-dependent effects on mito-ROS and spontaneous Ca(2+) release in hypertrophic rat cardiomyocytes.
Hamilton S, Terentyeva R, Perger F, Hernández Orengo B, Martin B, Gorr MW, Belevych AE, Clements RT, Györke S, Terentyev D., Free PMC Article | 10/30/2021 |
| This study, identified the role of the Pyk2/MCU pathway in the regulation of mitochondrial Ca2+ uptake and apoptotic signaling after ischemic stroke. | The Pyk2/MCU pathway in the rat middle cerebral artery occlusion model of ischemic stroke.
Zhang K, Yan J, Wang L, Tian X, Zhang T, Guo L, Li B, Wang W, Liu X. | 09/29/2018 |
| It has been shown that the propagation of the TRPV1-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX and MCU. | Privileged crosstalk between TRPV1 channels and mitochondrial calcium shuttling machinery controls nociception.
Nita II, Caspi Y, Gudes S, Fishman D, Lev S, Hersfinkel M, Sekler I, Binshtok AM. | 10/7/2017 |
| MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane. | Strategic Positioning and Biased Activity of the Mitochondrial Calcium Uniporter in Cardiac Muscle.
De La Fuente S, Fernandez-Sanz C, Vail C, Agra EJ, Holmstrom K, Sun J, Mishra J, Williams D, Finkel T, Murphy E, Joseph SK, Sheu SS, Csordás G., Free PMC Article | 09/30/2017 |
| Results suggest that both MCU and MICU1 are involved in mitochondrial Ca(2+) uptake in mast cells, while MCU plays a role in mast cell degranulation. | Impaired expression of the mitochondrial calcium uniporter suppresses mast cell degranulation.
Furuno T, Shinkai N, Inoh Y, Nakanishi M. | 08/20/2016 |
| These findings strongly suggest that MCU could be the major route for iron uptake into cardiac mitochondria | Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload.
Sripetchwandee J, KenKnight SB, Sanit J, Chattipakorn S, Chattipakorn N. | 10/31/2015 |
| study demonstrated that the MCU regulates the process of mitochondrial fission by controlling the Ca(2+) transport, directly upregulating mitochondrial fission proteins Drp1, Fis1 and indirectly reversing the MIEF1-induced mitochondrial fusion | The effect of mitochondrial calcium uniporter on mitochondrial fission in hippocampus cells ischemia/reperfusion injury.
Zhao L, Li S, Wang S, Yu N, Liu J. | 08/22/2015 |
| Cardiac responses to beta-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity | Cardiac responses to β-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity.
Fernández-Sada E, Silva-Platas C, Villegas CA, Rivero SL, Willis BC, García N, Garza JR, Oropeza-Almazán Y, Valverde CA, Mazzocchi G, Zazueta C, Torre-Amione G, García-Rivas G., Free PMC Article | 05/30/2015 |
| Blockage of MCU could alleviate iron accumulation and the associated injury following subarachnoid hemorrhage. | Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage.
Yan H, Hao S, Sun X, Zhang D, Gao X, Yu Z, Li K, Hang CH. | 04/25/2015 |
| The results of this study indicated that MCU may be related to mitochondrial fission via modulating mitochondrial Ca2+ uptake and this relationship between MCU and mitochondrial fission may protect the brain from I/R injury. | Role of mitochondrial calcium uniporter in regulating mitochondrial fission in the cerebral cortexes of living rats.
Liang N, Wang P, Wang S, Li S, Li Y, Wang J, Wang M. | 01/10/2015 |
| In conclusion, blocking MCU was demonstrated to exert protective effects against I/R injury and this process may be mediated by the prevention of energy failure. | The role of the mitochondrial calcium uniporter in cerebral ischemia/reperfusion injury in rats involves regulation of mitochondrial energy metabolism.
Zhao Q, Wang S, Li Y, Wang P, Li S, Guo Y, Yao R. | 07/26/2014 |
| Remote preconditioning protects myocardium against ischemia and reperfusion injury, possibly by inhibiting mitochondrial calcium uniporter opening. | [Mitochondrial calcium uniporter participates in remote preconditioning induced cardioprotection in rat hearts subjected to ischemia and reperfusion].
Xu J, Wang NF, Zhang SZ, Gao Q, Xia Q. | 10/6/2012 |
| Inhibition of mitochondrial calcium uniporter may protect heart from hypoxia/reoxygenation injury via decreasing the production of ROS in heart mitochondria. | [Role of mitochondrial calcium uniporter in myocardial hypoxia/reoxygenation induced injury].
Ye TM, Zhang SZ, Xia Q. | 06/9/2012 |
| The inhibition of mitochondrial calcium uniporter is involved in the mechanisms of ischemic postconditioning. | [Role of mitochondrial calcium uniporter in cardioprotection induced by ischemic postconditioning in isolated rat heart].
Yu TN, Hong H, Yang JQ, Gao Q, Xia Q. | 10/1/2011 |