| VGF: A prospective biomarker and therapeutic target for neuroendocrine and nervous system disorders. | VGF: A prospective biomarker and therapeutic target for neuroendocrine and nervous system disorders.
Wang Y, Qin X, Han Y, Li B. | 06/18/2022 |
| Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models. | Evaluation of VGF peptides as potential anti-obesity candidates in pre-clinical animal models.
Dalbøge LS, Jacobsen JM, Mehrotra S, Mercer AJ, Cox N, Liu F, Bennett CM, Said M, Tang-Christensen M, Raun K, Hansen JL, Grove KL, Baquero AF. | 12/4/2021 |
| Sexually experienced males. VGF-derived neuropeptides presumably serve as an effector molecule to increase sexual activity following sexual arousal induction. | VGF in the Medial Preoptic Nucleus Increases Sexual Activity Following Sexual Arousal Induction in Male Rats.
Maejima S, Abe Y, Yamaguchi S, Musatov S, Ogawa S, Kondo Y, Tsukahara S. | 05/11/2019 |
| Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element | Transcriptional regulation of the neuropeptide VGF by the neuron-restrictive silencer factor/neuron-restrictive silencer element.
Moon SM, Kim JS, Park BR, Kim DK, Kim SG, Kim HJ, Chun HS, Lee BK, Kim CS. | 10/17/2015 |
| various VGF peptides may regulate the hypothalamus-pituitary complex via specific neuroendocrine mechanisms while TLQP peptides may act at further, multiple levels via endocrine mechanisms involving the ovary. | VGF changes during the estrous cycle: a novel endocrine role for TLQP peptides?
Noli B, Brancia C, D'Amato F, Ferri GL, Cocco C., Free PMC Article | 07/25/2015 |
| VGF is involved in the control of metabolism and body weight homeostasis; active peptide fragments are generated from VGF, including TLQP-21, which controls reproductive function in female rats. | Characterization of the reproductive effects of the Vgf-derived peptide TLQP-21 in female rats: in vivo and in vitro studies.
Aguilar E, Pineda R, Gaytán F, Sánchez-Garrido MA, Romero M, Romero-Ruiz A, Ruiz-Pino F, Tena-Sempere M, Pinilla L. | 03/22/2014 |
| These results indicate that gC1qR is the receptor for TLQP-21 and plays an important role in chronic pain through activation of macrophages | Identification of a receptor for neuropeptide VGF and its role in neuropathic pain.
Chen YC, Pristerá A, Ayub M, Swanwick RS, Karu K, Hamada Y, Rice AS, Okuse K., Free PMC Article | 02/22/2014 |
| VGF expression under continuous stress is negatively regulated by dopaminergic neurons projecting from the hypothalamus. | Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine.
Tokizane K, Konishi H, Yasui M, Ogawa T, Sasaki K, Minamino N, Kiyama H. | 11/16/2013 |
| Specific VGF peptides appear to be widely represented in different gastric endocrine and other mucosal cell populations. | Selective expression of TLQP-21 and other VGF peptides in gastric neuroendocrine cells and modulation by feeding.
Brancia C, Cocco C, D'Amato F, Noli B, Sanna F, Possenti R, Argiolas A, Ferri GL. | 01/1/2011 |
| VGF protein is primarily cleaved at 10 sites through the processing pathway common to the brain and gastrointestinal tract. | Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat.
Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, Minamino N. | 10/23/2010 |
| Analysis of the contractile activity of VGF-derived peptides, biologically active in other systems, shows that only TLQP-21, corresponding to the 556-576 amino acid fragment of VGF precursor protein, can influence gastrointestinal contraction in vitro. | In vitro and in vivo pharmacological role of TLQP-21, a VGF-derived peptide, in the regulation of rat gastric motor functions.
Severini C, La Corte G, Improta G, Broccardo M, Agostini S, Petrella C, Sibilia V, Pagani F, Guidobono F, Bulgarelli I, Ferri GL, Brancia C, Rinaldi AM, Levi A, Possenti R., Free PMC Article | 04/19/2010 |
| Prolonged upregulation of VGF mRNA and protein was observed in injured dorsal root ganglion neurons, central terminals and their target dorsal horn neurons | Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury.
Moss A, Ingram R, Koch S, Theodorou A, Low L, Baccei M, Hathway GJ, Costigan M, Salton SR, Fitzgerald M., Free PMC Article | 01/21/2010 |
| the exercise-regulated gene VGF has an antidepressant effect | Antidepressant actions of the exercise-regulated gene VGF.
Hunsberger JG, Newton SS, Bennett AH, Duman CH, Russell DS, Salton SR, Duman RS. | 01/21/2010 |
| molecular mechanisms of its sorting to the regulated and polarized pathways of secretion | The neuroendocrine protein VGF is sorted into dense-core granules and is secreted apically by polarized rat thyroid epithelial cells.
Gentile F, Calì G, Zurzolo C, Corteggio A, Rosa P, Calegari F, Levi A, Possenti R, Puri C, Tacchetti C, Nitsch L. | 01/21/2010 |
| The identification in the Central nervous system of a previously uncharacterized VGF-derived peptide and its chronic i.c.v. infusion effected an increase in energy expenditure and limited the early phase of diet-induced obesity, is reported. | TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity.
Bartolomucci A, La Corte G, Possenti R, Locatelli V, Rigamonti AE, Torsello A, Bresciani E, Bulgarelli I, Rizzi R, Pavone F, D'Amato FR, Severini C, Mignogna G, Giorgi A, Schininà ME, Elia G, Brancia C, Ferri GL, Conti R, Ciani B, Pascucci T, Dell'Omo G, Muller EE, Levi A, Moles A., Free PMC Article | 01/21/2010 |
| the prohormone convertase cleavage site within the alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway | A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway.
Garcia AL, Han SK, Janssen WG, Khaing ZZ, Ito T, Glucksman MJ, Benson DL, Salton SR. | 01/21/2010 |
| VGF neuropeptides may regulate synaptic function in hippocampal neurons; C-terminal VGF peptides acutely increased synaptic charge in a dose-dependent manner | Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity.
Alder J, Thakker-Varia S, Bangasser DA, Kuroiwa M, Plummer MR, Shors TJ, Black IB., Free PMC Article | 01/21/2010 |