| Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling. | Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling.
Wang J, Zhan H, Wang M, Song H, Sun J, Zhao G., Free PMC Article | 10/24/2023 |
| Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in Rectal Nervous System Development of Fetal Rats with Anorectal Malformation. | Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in Rectal Nervous System Development of Fetal Rats with Anorectal Malformation.
Zhou Y, Yang Y, Dong R, Huang Y. | 06/23/2023 |
| Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells. | Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells.
Wu W, Wang Z, Zhang Z, Yang W, Fan X, Xu J, Huang Z, Shao Q. | 08/20/2022 |
| Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-beta/Smad, NF-kappaB and SHH Signaling Pathway. | Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad, NF-κB and SHH Signaling Pathway.
Zhou SS, Ai ZZ, Li WN, Li L, Zhu XY, Ba YM. | 07/31/2021 |
| Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease. | Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease.
Franchi F, Peterson KM, Quandt K, Domnick D, Kline TL, Olthoff M, Parvizi M, Tolosa EJ, Torres VE, Harris PC, Fernandez-Zapico ME, Rodriguez-Porcel MG., Free PMC Article | 05/8/2021 |
| Matrix metalloproteinase-9 regulates the blood brain barrier via the hedgehog pathway in a rat model of traumatic brain injury. | Matrix metalloproteinase-9 regulates the blood brain barrier via the hedgehog pathway in a rat model of traumatic brain injury.
Wu MY, Gao F, Yang XM, Qin X, Chen GZ, Li D, Dang BQ, Chen G. | 04/13/2021 |
| Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells. | Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells.
Xu Y, Wang J, Ding H. | 04/3/2021 |
| Sonic Hedgehog Regulates Bone Fracture Healing. | Sonic Hedgehog Regulates Bone Fracture Healing.
Takebe H, Shalehin N, Hosoya A, Shimo T, Irie K., Free PMC Article | 11/21/2020 |
| The Shh/Ptch1 pathway plays an essential role in the model of VD. | DL-3-n-butylphthalide alleviates vascular cognitive impairment by regulating endoplasmic reticulum stress and the Shh/Ptch1 signaling-pathway in rats.
Niu XL, Jiang X, Xu GD, Zheng GM, Tang ZP, Yin N, Li XQ, Yang YY, Lv PY. | 05/16/2020 |
| the results of the present study indicated that HG inhibited the Shh pathway in osteoblasts and resulted in patterning defects during osteoblastic differentiation and bone formation, while the activation of Shh signaling could suppress these deleterious effects. | Lentiviral‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling.
Jiang ZL, Jin H, Liu ZS, Liu MY, Cao XF, Jiang YY, Bai HD, Zhang B, Li Y., Free PMC Article | 02/8/2020 |
| Study provide evidence that spatiotemporal expression of Shh, Ptch1, and Gli1 was imbalanced during development of the lumbosacral spinal cord in rat embryos with ethylenethiourea induced anorectal malformations (ARMs). This imbalance may contribute to maldevelopment of the lumbosacral spinal cord and provide a molecular explanation for the complications observed in patients with ARMs. | The Expression of Shh, Ptch1, and Gli1 in the Developing Caudal Spinal Cord of Fetal Rats With Anorectal Malformations.
Yang Z, Gao L, Jia H, Bai Y, Wang W. | 11/16/2019 |
| Reintroduction of sonic hedgehog protein in an aged prostatectomy model is even more effective in promoting neurite formation/cavernous nerve regeneration than in adult. | Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus.
Dobbs R, Kalmanek E, Choe S, Harrington DA, Stupp SI, McVary KT, Podlasek CA., Free PMC Article | 05/4/2019 |
| These results revealed the critical roles of Id1 and SHH mediating Abeta-dependent cell cycle reentry and subsequently caspase-dependent apoptosis in the fully differentiated post-mitotic neurons. | Id1 and Sonic Hedgehog Mediate Cell Cycle Reentry and Apoptosis Induced by Amyloid Beta-Peptide in Post-mitotic Cortical Neurons.
Chao AC, Chen CH, Chang SH, Huang CT, Hwang WC, Yang DI. | 04/6/2019 |
| Data show that sonic hedgehog protein (SHH) was expressed mainly in the synaptic vesicles of hippocampus in both young postnatal and adult rats. | High frequency stimulation induces sonic hedgehog release from hippocampal neurons.
Su Y, Yuan Y, Feng S, Ma S, Wang Y., Free PMC Article | 11/10/2018 |
| data suggest that CGRP can partly protect AECII cells from hyperoxia-induced injury, and the upregulation of CGRP may be a potential therapeutic approach with which to combat hyperoxia-induced lung injury, which may be associated with the activation of the SHH signaling pathway. | CGRP attenuates hyperoxia-induced oxidative stress-related injury to alveolar epithelial type II cells via the activation of the Sonic hedgehog pathway.
Dang HX, Li J, Liu C, Fu Y, Zhou F, Tang L, Li L, Xu F. | 03/17/2018 |
| 'nNOS-Sox2-Shh' axis functions as a novel feedback compensatory mechanism to protect neurons against the early excitotoxicity and ischemic injury. | nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription.
Zhang D, Wang H, Liu H, Tao T, Wang N, Shen A. | 01/27/2018 |
| Tissue samples from fibrotic kidneys show enhanced TGF-beta1 levels, as well as upregulated hedgehog signaling activity, during the epithelial-mesenchymal transition process; these levels decrease when fibrosis is reversed. | Transforming growth factor-β1 stimulates hedgehog signaling to promote epithelial-mesenchymal transition after kidney injury.
Lu H, Chen B, Hong W, Liang Y, Bai Y. | 06/24/2017 |
| the results provide critical insights into the newly discovered role of Shh in phenotypic modulation of vascular smooth muscle cells which depends on KLF4. | Shh mediates PDGF-induced contractile-to-synthetic phenotypic modulation in vascular smooth muscle cells through regulation of KLF4.
Zeng Q, Wei B, Zhao Y, Wang X, Fu Q, Liu H, Li F. | 05/20/2017 |
| a positive role for Shh signaling, through the activator Smo, in oligodendrocyte differentiation after lineage specification. | Role of Sonic Hedgehog Signaling in Oligodendrocyte Differentiation.
Wang LC, Almazan G. | 03/18/2017 |
| The results suggest that SHH-Gli pathway is involved in the pathogenesis of Rheumatoid arthritis, and blocking SHH-Gli pathway inhibits Rheumatoid arthritis-synovial fibroblast cell proliferation and increases cell apoptosis, which may shed light on developing new ideas for Rheumatoid arthritis treatment. | The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis.
Qin S, Sun D, Li H, Li X, Pan W, Yan C, Tang R, Liu X. | 01/14/2017 |
| the activation of the SHH signaling pathway promotes the induction of EMT and renal tubulointerstitial fibrosis. | Sonic hedgehog-mediated epithelial-mesenchymal transition in renal tubulointerstitial fibrosis.
Bai Y, Lu H, Lin C, Xu Y, Hu D, Liang Y, Hong W, Chen B. | 12/31/2016 |
| These results thus established a signaling cascade of "Abeta --> Id1 --> HIF-1 --> SHH" in primary rat cortical cultures; furthermore, SHH may in part contribute to amyloid beta neurotoxicity. | Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Hung YH, Chang SH, Huang CT, Yin JH, Hwang CS, Yang LY, Yang DI. | 11/19/2016 |
| SHH over expression may play a pivotal contribute role in vasculogenesis through activating the SHH signals in post-myocardial ischemic-reperfusion injury | Activation of SHH signaling pathway promotes vasculogenesis in post-myocardial ischemic-reperfusion injury.
Guo W, Yi X, Ren F, Liu L, Wu S, Yang J., Free PMC Article | 10/8/2016 |
| Hh signaling plays an important role in post-natal osteogenesis in the setting of stress fracture healing, mediating its effects directly through regulation of bone formation and angiogenesis. | Hedgehog signaling mediates woven bone formation and vascularization during stress fracture healing.
Kazmers NH, McKenzie JA, Shen TS, Long F, Silva MJ., Free PMC Article | 09/3/2016 |
| SHH but not GDNF controls the phenotypic fate and therapeutic efficacy of grafted neural precursor cells in a model of nigrostriatal neurodegeneration. | Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration.
Madhavan L, Daley BF, Davidson BL, Boudreau RL, Lipton JW, Cole-Strauss A, Steece-Collier K, Collier TJ., Free PMC Article | 05/21/2016 |