| The Suppression of Ubiquitin C-Terminal Hydrolase L1 Promotes the Transdifferentiation of Auditory Supporting Cells into Hair Cells by Regulating the mTOR Pathway. | The Suppression of Ubiquitin C-Terminal Hydrolase L1 Promotes the Transdifferentiation of Auditory Supporting Cells into Hair Cells by Regulating the mTOR Pathway.
Kim YJ, Jeong IH, Ha JH, Kim YS, Sung S, Jang JH, Choung YH., Free PMC Article | 06/27/2024 |
| Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress. | Podocyte-specific deletion of ubiquitin carboxyl-terminal hydrolase L1 causes podocyte injury by inducing endoplasmic reticulum stress.
Hu Y, Qi C, Shi J, Tan W, Adiljan Abdurusul, Zhao Z, Xu Y, Wu H, Zhang Z., Free PMC Article | 08/9/2023 |
| Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats. | Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats.
Liu S, Wang C, Lu J, Dai G, Che H, He W., Free PMC Article | 06/26/2021 |
| UCHL1-dependent autophagic flux may have a potential as an otoprotective target for the treatment of gentamycin-induced auditory cell death. | Downregulated UCHL1 Accelerates Gentamicin-Induced Auditory Cell Death via Autophagy.
Kim YJ, Kim K, Lee YY, Choo OS, Jang JH, Choung YH. | 03/14/2020 |
| The increase of UCHL1 in the damaged tubules associated with high incidence of cell death. | Fluoxetine-induced androgenic failure impairs the seminiferous tubules integrity and increases ubiquitin carboxyl-terminal hydrolase L1 (UCHL1): Possible androgenic control of UCHL1 in germ cell death?
Câmara ML, Almeida TB, de Santi F, Rodrigues BM, Cerri PS, Beltrame FL, Sasso-Cerri E. | 03/30/2019 |
| results suggest that UCH-L1 may be associated with hippocampal mossy fiber sprouting followed the epileptogenesis through mediating phosphorylation of tau. | UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.
Wen Y, Wu Q, Shi Q, Xie Y, Dan W, Chen Y, Ma L. | 01/19/2019 |
| UCH-L1 can inhibit TNF-alpha-induced vascular smooth muscle cell migration, and this kind of effect may be partially due to its suppression role in NF-kappaB activation. | Ubiquitin Carboxyl Terminal Hydrolase L1 Attenuates TNF-α-Mediated Vascular Smooth Muscle Cell Migration Through Suppression of NF-κB Activation.
Gao X, Wu L, Wang K, Zhou X, Duan M, Wang X, Zhang Z, Liu X. | 12/22/2018 |
| investigated temporal profile of astrocytic and neuronal injury markers after TBI; different mechanisms underlie clearance of UCH-L1 and GFAP in CSF and serum | Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats.
Huang XJ, Glushakova O, Mondello S, Van K, Hayes RL, Lyeth BG. | 05/7/2016 |
| Potential of UCHL1 as biomarker for destruction of pancreatic beta cells. | Potential of UCHL1 as biomarker for destruction of pancreatic beta cells.
Brackeva B, De Punt V, Kramer G, Costa O, Verhaeghen K, Stangé G, Sadones J, Xavier C, Aerts JM, Gorus FK, Martens GA. | 11/21/2015 |
| UCH-L1 is differently processed in neurons compared with clonal cell lines and that farnesylation does not account for the membrane association in neurons. | The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons.
Bishop P, Rubin P, Thomson AR, Rocca D, Henley JM., Free PMC Article | 04/18/2015 |
| The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. | The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis.
Sosna J, Voigt S, Mathieu S, Kabelitz D, Trad A, Janssen O, Meyer-Schwesinger C, Schütze S, Adam D., Free PMC Article | 02/22/2014 |
| in AD, Abeta may down-regulate UCH-L1 in the AD brain, which in turn impairs BDNF/TrkB-mediated retrograde signaling, compromising synaptic plasticity and neuronal survival. | β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.
Poon WW, Carlos AJ, Aguilar BL, Berchtold NC, Kawano CK, Zograbyan V, Yaopruke T, Shelanski M, Cotman CW., Free PMC Article | 08/31/2013 |
| Restoring UCH-L1 activity by transduction of primary neurons with a UCH-L1 fusion protein protected neurons, while inhibition of UCH-L1 exacerbates hypoxic injury. | Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.
Liu H, Li W, Ahmad M, Miller TM, Rose ME, Poloyac SM, Uechi G, Balasubramani M, Hickey RW, Graham SH., Free PMC Article | 11/26/2011 |
| PGP9.5 messenger was decreased in nitrofen-exposed animals on E18 (esophagus) or E15 (small bowel), and increased on E21 in the esophagus and E18 in small bowel. | Abnormal development of the enteric nervous system in rat embryos and fetuses with congenital diaphragmatic hernia.
Martínez L, Aras-López R, Lancha S, Vallejo-Cremades MT, Pederiva F, XiaoMei L, Tovar JA. | 05/28/2011 |
| Zinc deficiency could induce downregulation of Uch-L1 expression. | [Study of zinc on the modulation of Uch-L1 expression in hippocampus of growing rats].
Liu J, Jiang Y, Huang C, Fang H. | 10/23/2010 |
| analysis of a possible mechanistic link between UCH-L1 modification by cyclopentenone prostaglandins and the etiology of neurodegeneration | Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
Koharudin LM, Liu H, Di Maio R, Kodali RB, Graham SH, Gronenborn AM., Free PMC Article | 05/31/2010 |
| This protein has been found differentially expressed in the lumbar spinal cord from rats submitted to peripheral lesion during neonatal period. | Proteome analysis of lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.
Castro-Dias E, Vieira AS, Werneck CC, Langone F, Novello JC, Martins-de-Souza D. | 04/21/2010 |
| results demonstrated that zinc modulated the expression of ubiquitin C-terminal hydrolase L1 (Uch-L1) and cAMP-responsive element-binding protein (CREB) at the protein and/or transcription levels in hippocampal neurons | Depletion of intracellular zinc down-regulates expression of Uch-L1 mRNA and protein, and CREB mRNA in cultured hippocampal neurons.
Liu J, Jiang YG, Huang CY, Fang HY, Fang HT, Pang W. | 01/21/2010 |
| UCH-L1 is widely expressed in neurons in all brain regions analyzed, including dopamine neurons of the midbrain. In the periphery, UCH-L1 expression remains restricted to neurons in all organs examined. | DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents.
Galter D, Westerlund M, Belin AC, Olson L. | 01/21/2010 |
| UCHL1 may partially attenuate vascular remodeling through inhibition of NF-kappaB activity. | Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.
Takami Y, Nakagami H, Morishita R, Katsuya T, Cui TX, Ichikawa T, Saito Y, Hayashi H, Kikuchi Y, Nishikawa T, Baba Y, Yasuda O, Rakugi H, Ogihara T, Kaneda Y. | 01/21/2010 |
| Complete loss of UCH-L1 immunoreactivity in orofacial skin nerve fibers in dithranol-treated animals. | Dithranol abolishes UCH-L1 immunoreactivity in the nerve fibers of the rat orofacial skin.
Orojan I, Szigeti C, Varszegi S, Dobo E, Gulya K. | 01/21/2010 |