| P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy. | P2Y1 and P2Y2 receptors differ in their role in the regulation of signaling pathways during unloading-induced rat soleus muscle atrophy.
Zaripova KA, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL. | 01/3/2024 |
| P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury. | P2Y2 Receptor Mediated Neuronal Regeneration and Angiogenesis to Affect Functional Recovery in Rats with Spinal Cord Injury.
Cheng R, Zhu G, Ni C, Wang R, Sun P, Tian L, Zhang L, Zhang J, Ye X, Luo B., Free PMC Article | 04/9/2022 |
| P2RY2 Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting YAP Phosphorylation and Reducing Mitochondrial Fission. | P2RY2 Alleviates Cerebral Ischemia-Reperfusion Injury by Inhibiting YAP Phosphorylation and Reducing Mitochondrial Fission.
Xue LX, Chen SF, Xue SX, Zhang XZ, Lian YJ. | 01/22/2022 |
| Expanding Role of Dopaminergic Inhibition in Hypercapnic Responses of Cultured Rat Carotid Body Cells: Involvement of Type II Glial Cells. | Expanding Role of Dopaminergic Inhibition in Hypercapnic Responses of Cultured Rat Carotid Body Cells: Involvement of Type II Glial Cells.
Leonard EM, Nurse CA., Free PMC Article | 02/20/2021 |
| The authors concluded that P2Y2R participates in controlling the proliferative rate of theca cells from healthy ovaries, but this regulation is lost during experimentally-induced polycystic ovarian syndrome. | Experimental polycystic ovarian syndrome is associated with reduced expression and function of P2Y2 receptors in rat theca cells.
Campos-Contreras ADR, Juárez-Mercado AP, González-Gallardo A, Chávez-Genaro R, Garay E, De Ita-Pérez DL, Díaz-Muñoz M, Vázquez-Cuevas FG. | 04/25/2020 |
| downregulation of P2Y2 and HuD may partly be related to the development of the enteric nervous system in anorectal malformations embryos. | Downregulation of P2Y2 and HuD during the development of the enteric nervous system in fetal rats with anorectal malformations.
Zheng Z, Chen B, Jin Z, Gao M, Tang C, Mao Y, Qu Y, Liu Y., Free PMC Article | 12/14/2019 |
| lysosomal exocytosis of ATP is coupled to P2Y2 receptor in marginal cells in the stria vascular in neonatal rats | Lysosomal exocytosis of ATP is coupled to P2Y(2) receptor in marginal cells in the stria vascular in neonatal rats.
Liu B, Cao W, Li J, Liu J. | 08/10/2019 |
| study suggests that P2Y2R is involved in regulation of bone turnover | Bone turnover is altered in transgenic rats overexpressing the P2Y2 purinergic receptor.
Ellegaard M, Agca C, Petersen S, Agrawal A, Kruse LS, Wang N, Gartland A, Jensen JB, Jørgensen NR, Agca Y., Free PMC Article | 07/28/2018 |
| Activation of renal medullary P2Y2/P2Y4 receptors promotes ET-1-dependent natriuresis in ovariectomized rats. | Ovariectomy uncovers purinergic receptor activation of endothelin-dependent natriuresis.
Gohar EY, Kasztan M, Becker BK, Speed JS, Pollock DM., Free PMC Article | 09/23/2017 |
| Uridine triphosphate regulates the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells via the P2Y2 receptor. | Regulation of the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells by extracellular uridine triphosphate: The role of P2Y2 receptor and ERK1/2 signaling.
Li W, Wei S, Liu C, Song M, Wu H, Yang Y., Free PMC Article | 10/22/2016 |
| Myocardial expression of the protective P2Y2 receptor subtype is decreased in coronary ischemia-reperfusion injury. | Altered expression of P2Y2 and P2X7 purinergic receptors in the isolated rat heart mediates ischemia-reperfusion injury.
Granado M, Amor S, Montoya JJ, Monge L, Fernández N, García-Villalón ÁL. | 07/2/2016 |
| in 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by R2Y2 receptors. R2Y4 receptors took part in the realization of negative inotropic response to uridine triphosphate in all age groups | Involvement of P2Y(2,4) receptors in the regulation of myocardial contractility in growing rats.
Anikina TA, Anisimova IN, Zverev AA, Sitdikov FG, Zefirov TL. | 01/10/2015 |
| The results of this study suggest that inhibition of P2Y receptors leads to down-regulation of ERK-mediated phosphorylation and increase of the expression of I(A)-related Kv channels in trigeminal ganglion neurons. | Inhibition of G protein-coupled P2Y2 receptor induced analgesia in a rat model of trigeminal neuropathic pain.
Li N, Lu ZY, Yu LH, Burnstock G, Deng XM, Ma B., Free PMC Article | 10/18/2014 |
| Thus, P2Y2R activation protects cardiomyocytes from hypoxia in vitro and reduces post-ischemic myocardial damage in vivo. | P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo.
Hochhauser E, Cohen R, Waldman M, Maksin A, Isak A, Aravot D, Jayasekara PS, Müller CE, Jacobson KA, Shainberg A., Free PMC Article | 08/30/2014 |
| UTP-induced migratory responses required for salivary gland acinar cell self-organization are mediated by the P2Y2R. | P2Y2 nucleotide receptor activation enhances the aggregation and self-organization of dispersed salivary epithelial cells.
El-Sayed FG, Camden JM, Woods LT, Khalafalla MG, Petris MJ, Erb L, Weisman GA., Free PMC Article | 08/30/2014 |
| This is the first report of selective coupling of one type of SK channel to purinergic stimulation of microglia, transactivation of KCa3.1 channels by CRAC/Orai1. | Selective activation of KCa3.1 and CRAC channels by P2Y2 receptors promotes Ca(2+) signaling, store refilling and migration of rat microglial cells.
Ferreira R, Schlichter LC., Free PMC Article | 11/16/2013 |
| A developmental function of P2Y2R in promoting synaptic gene expression. | Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation.
Choi RC, Chu GK, Siow NL, Yung AW, Yung LY, Lee PS, Lo CC, Simon J, Dong TT, Barnard EA, Tsim KW. | 09/14/2013 |
| A significant cellular coexpression of P2X3 and P2Y2 in rat DRG neurons. | Control of P2X3 channel function by metabotropic P2Y2 utp receptors in primary sensory neurons.
Mo G, Peleshok JC, Cao CQ, Ribeiro-da-Silva A, Séguéla P. | 07/6/2013 |
| Carotid body type II cells may function as ATP amplifiers during chemotransduction via paracrine activation of P2Y2Rs and Panx-1 channels. | P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP.
Zhang M, Piskuric NA, Vollmer C, Nurse CA., Free PMC Article | 02/16/2013 |
| Uridine adenosine tetraphosphate induced Nox1-dependent reactive oxygen species generation, which further stimulated MCP-1 formation via MAPK phosphorylation in vascular smooth muscle cells. This process requires the activation of P2Y(2). | The endothelium-derived contracting factor uridine adenosine tetraphosphate induces P2Y(2)-mediated pro-inflammatory signaling by monocyte chemoattractant protein-1 formation.
Schuchardt M, Prüfer J, Prüfer N, Wiedon A, Huang T, Chebli M, Jankowski V, Jankowski J, Schäfer-Korting M, Zidek W, van der Giet M, Tölle M. | 03/17/2012 |
| Amyloid precursor protein (APP) production and secretion are regulated by activation of P2Y2/4 receptors coupled to protein kinase signaling pathways, in a demonstration using astrocytes as a potential source of APP. | P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes.
Tran MD. | 02/25/2012 |
| ATP induces [Ca(2+)](i)-dependent contraction in intestinal subepithelial myofibroblasts, which is mediated through the P2Y(2) receptor | ATP induces contraction mediated by the P2Y(2) receptor in rat intestinal subepithelial myofibroblasts.
Nakamura T, Iwanaga K, Murata T, Hori M, Ozaki H. | 07/9/2011 |
| Therefore, the spatio-temporal pattern of P2Y(2) gene expression after spinal cord injury suggests a role in the pathophysiology response generated after trauma. | P2Y2 receptor expression is altered in rats after spinal cord injury.
Rodríguez-Zayas AE, Torrado AI, Miranda JD., Free PMC Article | 01/15/2011 |
| Data suggest that increased production of PGE2 by the medullary collecting duct in postobstructive uropathy may be due to increased expression and activity of the P2Y2 receptor. | Potential involvement of P2Y2 receptor in diuresis of postobstructive uropathy in rats.
Zhang Y, Kohan DE, Nelson RD, Carlson NG, Kishore BK., Free PMC Article | 03/22/2010 |
| transgenic rat model of P2Y(2)R overexpression may prove useful for linking P2Y(2)R upregulation with chronic inflammatory diseases, neurodegenerative diseases and Sjogren's syndrome | Development of a novel transgenic rat overexpressing the P2Y(2) nucleotide receptor using a lentiviral vector.
Agca C, Seye C, Kashuba Benson CM, Rikka S, Chan AW, Weisman GA, Agca Y., Free PMC Article | 01/21/2010 |