| GTF2E2 downregulated by miR-340-5p inhibits the malignant progression of glioblastoma. | GTF2E2 downregulated by miR-340-5p inhibits the malignant progression of glioblastoma.
Qiao X, Chen Y, Wang Z, Peng N, Niu W, Hou S, Wu J, Ji Y, Niu C, Cheng C. | 12/26/2023 |
| Mayaro Virus Non-Structural Protein 2 Circumvents the Induction of Interferon in Part by Depleting Host Transcription Initiation Factor IIE Subunit 2. | Mayaro Virus Non-Structural Protein 2 Circumvents the Induction of Interferon in Part by Depleting Host Transcription Initiation Factor IIE Subunit 2.
Ishida R, Cole J, Lopez-Orozco J, Fayad N, Felix-Lopez A, Elaish M, Luo SY, Julien O, Kumar A, Hobman TC., Free PMC Article | 01/8/2022 |
| Nucleolar TFIIE plays a role in ribosomal biogenesis and performance. | Nucleolar TFIIE plays a role in ribosomal biogenesis and performance.
Phan T, Maity P, Ludwig C, Streit L, Michaelis J, Tsesmelis M, Scharffetter-Kochanek K, Iben S., Free PMC Article | 12/25/2021 |
| functional analysis of Trichothiodystrophy causative TFIIEbeta mutation demonstrates that mutant TFIIEbeta strongly reduces the total amount of the entire TFIIE complex, with a remarkable temperature-sensitive transcription defect. | Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue.
Theil AF, Mandemaker IK, van den Akker E, Swagemakers SMA, Raams A, Wüst T, Marteijn JA, Giltay JC, Colombijn RM, Moog U, Kotzaeridou U, Ghazvini M, von Lindern M, Hoeijmakers JHJ, Jaspers NGJ, van der Spek PJ, Vermeulen W., Free PMC Article | 06/30/2018 |
| The N-terminal half of TFIIEalpha forms an extended winged helix (WH) domain with an additional helix, followed by a zinc-finger domain. TFIIEbeta contains the WH2 domain, followed by two coiled-coil helices intertwining with TFIIEalpha. | Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution.
Miwa K, Kojima R, Obita T, Ohkuma Y, Tamura Y, Mizuguchi M. | 06/24/2017 |
| We underline role of TFIIE in transcription and its distinction from nucleotide excision repair. Trichothiodystrophy individuals with mutations in GTF2E2 highlight the importance of the direct interaction between TFIIH and TFIIE in transcription process. | GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.
Kuschal C, Botta E, Orioli D, Digiovanna JJ, Seneca S, Keymolen K, Tamura D, Heller E, Khan SG, Caligiuri G, Lanzafame M, Nardo T, Ricotti R, Peverali FA, Stephens R, Zhao Y, Lehmann AR, Baranello L, Levens D, Kraemer KH, Stefanini M., Free PMC Article | 09/3/2016 |
| PC4 plays essential roles in the transition step from transcription initiation to elongation by binding to melted DNA in collaboration with TFIIEbeta. | Transcription cofactor PC4 plays essential roles in collaboration with the small subunit of general transcription factor TFIIE.
Akimoto Y, Yamamoto S, Iida S, Hirose Y, Tanaka A, Hanaoka F, Ohkuma Y. | 05/30/2015 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.
Festen EA, Stokkers PC, van Diemen CC, van Bodegraven AA, Boezen HM, Crusius BJ, Hommes DW, van der Woude CJ, Balschun T, Verspaget HW, Schreiber S, de Jong DJ, Franke A, Dijkstra G, Wijmenga C, Weersma RK. | 12/2/2009 |
| TFIIE is an alpha/beta heterodimer in solution; A model for the quaternary architecture of the complex is proposed that provides a structural framework to discuss the function of TFIIE in the context of RNA polymerase II transcription initiation. | Structure and oligomeric state of human transcription factor TFIIE.
Jawhari A, Uhring M, De Carlo S, Crucifix C, Tocchini-Valentini G, Moras D, Schultz P, Poterszman A., Free PMC Article | 01/21/2010 |
| These data suggest a model in which TFIIE binds to a position adjacent to the initiation site via the forkhead domain, enabling TFIIH to begin opening the promoter. | Central forkhead domain of human TFIIE beta plays a primary role in binding double-stranded DNA at transcription initiation.
Tanaka A, Watanabe T, Iida Y, Hanaoka F, Ohkuma Y. | 01/21/2010 |
| introduced point mutations into two regions located near the carboxy terminus of TFIIE beta and identified the functionally essential amino acid residues that bind to RNA polymerase II | The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II.
Watanabe T, Hayashi K, Tanaka A, Furumoto T, Hanaoka F, Ohkuma Y., Free PMC Article | 01/21/2010 |