| Remote ischemic postconditioning alleviates cerebral ischemic injury through SERCA2/endoplasmic reticulum stress-mediated apoptosis. | Remote ischemic postconditioning alleviates cerebral ischemic injury through SERCA2/endoplasmic reticulum stress-mediated apoptosis.
Chen W, Li M, Lei X, Cheng Y, Wu X, Sun X, Wu Y, Li Z, Luo G, Wei M. | 02/9/2024 |
| Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca[2+] waves. | Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and SERCA2a activity and modifies the interplay of these proteins during Ca(2+) waves.
Gómez-Viquez NL, Balderas-Villalobos J, Bello-Sánchez MD, Mayorga-Luna M, Mailloux-Salinas P, García-Castañeda M, Ríos-Pérez EB, Mártinez-Ávila MA, Camacho-Castillo LDC, Bravo G, Ávila G, Altamirano J, Carvajal K. | 09/19/2023 |
| Effects of MiR-214-3p Regulation of SERCA2a Expression on Contractility of Cardiomyocytes in Heart Failure Model. | Effects of MiR-214-3p Regulation of SERCA2a Expression on Contractility of Cardiomyocytes in Heart Failure Model.
Hu T, Liu L. | 09/3/2022 |
| Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a. | Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a.
Chen J, Liu Y, Pan D, Xu T, Luo Y, Wu W, Wu P, Zhu H, Li D., Free PMC Article | 05/14/2022 |
| Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool. | Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool.
He W, Huang D, Guo S, Wang D, Guo J, Cala SE, Chen Z. | 07/17/2021 |
| Relative role of T-tubules disruption and decreased SERCA2 on contractile dynamics of isolated rat ventricular myocytes. | Relative role of T-tubules disruption and decreased SERCA2 on contractile dynamics of isolated rat ventricular myocytes.
Celestino-Montes A, Pérez-Treviño P, Sandoval-Herrera MD, Gómez-Víquez NL, Altamirano J. | 01/2/2021 |
| Roles of sarcoplasmic reticulum Ca(2+) ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model. | Roles of sarcoplasmic reticulum Ca(2+) ATPase pump in the impairments of lymphatic contractile activity in a metabolic syndrome rat model.
Lee Y, Chakraborty S, Muthuchamy M., Free PMC Article | 12/12/2020 |
| Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring. | Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring.
Logantha SJRJ, Kharche SR, Zhang Y, Atkinson AJ, Hao G, Boyett MR, Dobrzynski H., Free PMC Article | 10/24/2020 |
| Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia-reperfusion injury. | Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia-reperfusion injury.
Roczkowsky A, Chan BYH, Lee TYT, Mahmud Z, Hartley B, Julien O, Armanious G, Young HS, Schulz R. | 10/24/2020 |
| MicroRNA-30b regulates insulin sensitivity by targeting SERCA2b in non-alcoholic fatty liver disease. | MicroRNA-30b regulates insulin sensitivity by targeting SERCA2b in non-alcoholic fatty liver disease.
Dai LL, Li SD, Ma YC, Tang JR, Lv JY, Zhang YQ, Miao YL, Ma YQ, Li CM, Chu YY, Wang KH, Ma LQ, Zou CG. | 09/19/2020 |
| Our results showed that Sal A pretreatment alleviated cardiac dysfunction and Ca(2+) overload induced by ATO in vivo and vitro. Moreover, Sal A increased sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) activity and expression, alleviated [Ca(2+)]ER depletion, and decreased ER stress-related protein expression. | The Cardiotoxicity Induced by Arsenic Trioxide is Alleviated by Salvianolic Acid A via Maintaining Calcium Homeostasis and Inhibiting Endoplasmic Reticulum Stress.
Wang R, Zhang J, Wang S, Wang M, Ye T, Du Y, Xie X, Ye J, Sun G, Sun X., Free PMC Article | 06/8/2019 |
| Increased m-RNA expression of SERCA2 in the melatonin treated group, without increase of m-RNA expression of the NCX1. The TD did not affect levels of SERCA2 and NCX1 m-RNA expressions. The combined melatonin and TD treatment reduced the m-RNA expression of SERCA2 | THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE.
Vasques ER, Cunha JEM, Kubrusly MS, Coelho AM, Sanpietri SN, Nader HB, Tersariol ILS, Lima MA, Chaib E, D'Albuquerque LAC., Free PMC Article | 01/26/2019 |
| Low Serca2a expression is associated with ischemia-reperfusion- induced Injury and heart failure. | Cardioprotective Effects of Serca2a Overexpression Against Ischemiareperfusion- induced Injuries in Rats.
Jiang Y, Tian LL, Wang LH, Zhao XD, Chen JW, Murao K, Zhu W, Dong L, Wang GQ, Sun WP, Zhang GX. | 09/1/2018 |
| ERSE present in the SERCA2 proximal promoter contains a CCAAT box that is involved in basal and ERS-mediated hSERCA2 transcriptional activation. | The CCAAT box in the proximal SERCA2 gene promoter regulates basal and stress-induced transcription in cardiomyocytes.
Fragoso-Medina J, Rodriguez G, Zarain-Herzberg A. | 07/14/2018 |
| We find that prolonged exposure of A7r5 cells to hyperglycemia (weeks) is associated with changes to Ca(2+) signaling, including most prominently an inhibition of the passive ER Ca(2+) leak and the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA). | Effects of Hyperglycemia on Vascular Smooth Muscle Ca(2+) Signaling.
El-Najjar N, Kulkarni RP, Nader N, Hodeify R, Machaca K., Free PMC Article | 04/14/2018 |
| SERCA2a and the PKA/PLN pathway are inhibited by TSH in rat cardiomyocytes | TSH inhibits SERCA2a and the PKA/PLN pathway in rat cardiomyocytes.
Dong J, Gao C, Liu J, Cao Y, Tian L., Free PMC Article | 01/27/2018 |
| Whether the increased Ca(2+) transient and neurotransmission after SERCA2A overexpression contributes to enhanced sympathoexcitation in heart failure patients remains to be determined. | Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca(2+) Regulation.
Shanks J, Herring N, Johnson E, Liu K, Li D, Paterson DJ., Free PMC Article | 08/12/2017 |
| This study demonstrated that Slowed relaxation of the diaphragm in septic rats was associated with reduced expression of SERCA2. | Slowed relaxation of diaphragm in septic rats is associated with reduced expression of sarco-endoplasmic reticulum CA(2+) -ATPase genes SERCA1 and SERCA2.
Wu J, Zhang JY, Gong Y, Li ST. | 07/1/2017 |
| findings show that SERCA's lipid annulus may influence its susceptibility to oxidative damage, which could have implications in muscular dystrophy and age-related muscle wasting | Saturation of SERCA's lipid annulus may protect against its thermal inactivation.
Fajardo VA, Trojanowski N, Castelli LM, Miotto PM, Amoye F, Ward WE, Tupling AR, LeBlanc PJ. | 07/1/2017 |
| Nevertheless, the functional role of protein serotonylation in controlling SAN automaticity is largely unexplored. In this study, we screened the cardiomyocytes proteins and found that sarco(endo)plasmic reticulum Ca ATPase type 2a (SERCA2a) can be serotonylated. Simulation studies using mathematical SAN cell model showed that variation of Ca(2+) affinity of SERCA2a pump cause either tachycardia or bradycardia. | SERCA2a was serotonylated and may regulate sino-atrial node pacemaker activity.
Wang Q, Wang D, Yan G, Qiao Y, Sun L, Zhu B, Wang X, Tang C. | 06/3/2017 |
| SERCA2b as a novel target for HIF-1 and may provide potential implications for HIF-1alpha-stabilizing strategy in activating endogenous neuroprotection | HIF-1α-mediated upregulation of SERCA2b: The endogenous mechanism for alleviating the ischemia-induced intracellular Ca(2+) store dysfunction in CA1 and CA3 hippocampal neurons.
Kopach O, Maistrenko A, Lushnikova I, Belan P, Skibo G, Voitenko N. | 02/25/2017 |
| potential mechanism in which iron exacerbates the diabetes-induced oxidative/nitrative modification of SERCA2a | Association of cardiac injury with iron-increased oxidative and nitrative modifications of the SERCA2a isoform of sarcoplasmic reticulum Ca(2+)-ATPase in diabetic rats.
Li X, Li W, Gao Z, Li H. | 01/28/2017 |
| Our findings suggest that unlike the ventricle, SERCA2a is not a key regulator of cardiac alternans in the atrium. Importantly, SERCA2a overexpression in atrial myocytes can increase SCR, which may be arrhythmogenic | Atrial SERCA2a Overexpression Has No Affect on Cardiac Alternans but Promotes Arrhythmogenic SR Ca2+ Triggers.
Nassal MM, Wan X, Laurita KR, Cutler MJ., Free PMC Article | 05/21/2016 |
| This first-in-class small-molecule activator targeting SERCA2a SUMOylation may serve as a potential therapeutic strategy for treatment of heart failure | Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure.
Kho C, Lee A, Jeong D, Oh JG, Gorski PA, Fish K, Sanchez R, DeVita RJ, Christensen G, Dahl R, Hajjar RJ., Free PMC Article | 03/26/2016 |
| SERCA2 overexpression protects against primary rat cardiomyocyte death due to chlorine. | Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity.
Ahmad S, Ahmad A, Hendry-Hofer TB, Loader JE, Claycomb WC, Mozziconacci O, Schöneich C, Reisdorph N, Powell RL, Chandler JD, Day BJ, Veress LA, White CW., Free PMC Article | 03/5/2016 |