| Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins. | Interspecies and regional variability of alcohol action on large cerebral arteries: regulation by KCNMB1 proteins.
Mysiewicz S, North KC, Moreira L Jr, Odum SJ, Bukiya AN, Dopico AM., Free PMC Article | 03/21/2023 |
| Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma. | Cholesterol activates BK channels by increasing KCNMB1 protein levels in the plasmalemma.
Bukiya AN, Leo MD, Jaggar JH, Dopico AM., Free PMC Article | 08/28/2021 |
| Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner. | Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner.
Reed JT, Pareek T, Sriramula S, Pabbidi MR. | 02/13/2021 |
| Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring. | Antenatal Dexamethasone Exposure Impairs the High-Conductance Ca(2+)-Activated K(+) Channels via Epigenetic Alteration at Gene Promoter in Male Offspring.
Xu T, Zhao M, Li H, Zhou X, Liu B, Sun M, Xu Z, Gao Q. | 12/19/2020 |
| Data show that potassium channel subfamily M regulatory beta subunit 1 (beta1 Subunit) surface trafficking is Impaired in cerebral arteries of stroke-prone spontaneously hypertensive rats (SP-SHRs). | Impaired Trafficking of β1 Subunits Inhibits BK Channels in Cerebral Arteries of Hypertensive Rats.
Leo MD, Zhai X, Yin W, Jaggar JH., Free PMC Article | 04/13/2019 |
| hypertension and aging exert opposing effects on DNA methylation at BKbeta1 promoter, subsequently resulting in different beta1 expression | BK(Ca) channel activity and vascular contractility alterations with hypertension and aging via β1 subunit promoter methylation in mesenteric arteries.
Zhang Y, Liao J, Zhang L, Li S, Wu Y, Shi L. | 03/23/2019 |
| Study showed that in human and rat arterial myocytes, membrane depolarization rapidly increased the cell surface abundance of auxiliary BK beta1 subunits but not that of the pore-forming BKalpha channels. Membrane depolarization stimulated voltage-dependent Ca(2+) channels, leading to Ca(2+) influx and the activation of Rho kinase (ROCK) 1 and 2. | Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction.
Leo MD, Zhai X, Muralidharan P, Kuruvilla KP, Bulley S, Boop FA, Jaggar JH., Free PMC Article | 02/24/2018 |
| n-3 PUFAs protect the coronary BK channel function and coronary vasoreactivity in diabetic rats as a result of not only increasing BK-beta1 protein expressions, but also decreasing coronary artery tension and coronary smooth muscle cytosolic Ca2+ concentrations. | Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats.
Tang X, Qian LL, Wang RX, Yao Y, Dang SP, Wu Y, Wang W, Ji Y, Sun MQ, Xia DY, Liu XY, Zhang DM, Chai Q, Lu T. | 12/23/2017 |
| Data show that leukotriene B4, but not other leukotrienes of the LT4 family, activates recombinant (cbv1-beta1) Lrge-conductance calcium-activated potassium (BK) channels. | Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.
Bukiya AN, McMillan J, Liu J, Shivakumar B, Parrill AL, Dopico AM., Free PMC Article | 04/25/2015 |
| aging decreases capability of MaxiK channel in regulating vascular tone in the MA, which may be partially mediated by unparallel downregulation of alpha- and beta1-subunit expression | Aging decreases the contribution of MaxiK channel in regulating vascular tone in mesenteric artery by unparallel downregulation of α- and β1-subunit expression.
Shi L, Liu X, Li N, Liu B, Liu Y. | 06/7/2014 |
| The expression of BK(Ca) beta1- but not alpha-subunit was significantly enhanced after exercise training | Aerobic exercise increases BK(Ca) channel contribution to regulation of mesenteric arterial tone by upregulating β1-subunit.
Shi L, Liu B, Li N, Xue Z, Liu X. | 06/22/2013 |
| BKbeta1 transcripts and protein are detected in several astrocytic populations and cultured cells, to a lesser degree than BKbeta4 channels. | Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytes.
Seidel KN, Derst C, Salzmann M, Höltje M, Priller J, Markgraf R, Heinemann SH, Heilmann H, Skatchkov SN, Eaton MJ, Veh RW, Prüss H. | 03/31/2012 |
| KCNMB1 was the dominant beta subunit in the ductus arteriosus, and the amount of beta1 mRNAs was greatest in the mature DA. | The role of the large-conductance voltage-dependent and calcium-activated potassium (BK(Ca)) channels in the regulation of rat ductus arteriosus tone.
Sun F, Hayama E, Katsube Y, Matsuoka R, Nakanishi T. | 02/26/2011 |
| Immunocytochemical staining of rat hypothalamic neurons indicates strong BKbeta1 expression in the supraoptic nucleus and the magno- and parvocellular parts of the paraventricular nucleus. | BKbeta1 subunits contribute to BK channel diversity in rat hypothalamic neurons.
Salzmann M, Seidel KN, Bernard R, Prüss H, Veh RW, Derst C. | 01/22/2011 |
| ageing was associated with a reduction in BK(Ca) channels, and exercise training (ET) partly reversed this reduction. low-intensity ET may be beneficial in restoring age-related decline in coronary vasodilatory properties mediated by BK(Ca) channels. | Exercise training attenuates ageing-induced BKCa channel downregulation in rat coronary arteries.
Albarwani S, Al-Siyabi S, Baomar H, Hassan MO. | 08/16/2010 |
| Downregulation of BKCa channel beta1-subunit in the type-2 diabetic cerebral artery smooth muscle cells contributes to cerebral vascular complication in type-2 diabetes via reducing activity of BKCa channels, increasing vascular tone and blood pressure. | Experimental diabetes mellitus down-regulates large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle and alters functional conductance.
Wang Y, Zhang HT, Su XL, Deng XL, Yuan BX, Zhang W, Wang XF, Yang YB. | 08/16/2010 |
| adaptation to hypoxia exerts a protective role on cardiomyocytes subjected to ischemia and that, unexpectedly, this form of preconditioning absolutely depends on Hif-2alpha. | Hypoxia inducible factor-2alpha stabilization and maxi-K+ channel beta1-subunit gene repression by hypoxia in cardiac myocytes: role in preconditioning.
Bautista L, Castro MJ, López-Barneo J, Castellano A. | 01/21/2010 |
| There is a selective distribution of auxiliary beta1 subunits to the somatic and dendritic compartments and beta4 subunits to the terminal compartment of neurons in the hypothalamic-neurohypophysial system. | Compartmentalized beta subunit distribution determines characteristics and ethanol sensitivity of somatic, dendritic, and terminal large-conductance calcium-activated potassium channels in the rat central nervous system.
Wynne PM, Puig SI, Martin GE, Treistman SN., Free PMC Article | 01/21/2010 |
| lower expression of the beta1 subunit during genetic borderline and severe hypertension reduced BK channel activity by decreasing the sensitivity of these channels to physiological changes in Ca2+ | Downregulation of the BK channel beta1 subunit in genetic hypertension.
Amberg GC, Santana LF. | 01/21/2010 |
| The large conductance (BK) beta 1 channel subunit confers Ca2+-sensitivity to BK channel complexes, and both transcript and protein levels for BK beta 1 were appreciably lower in diabetic retinal arterioles. | Diabetes downregulates large-conductance Ca2+-activated potassium beta 1 channel subunit in retinal arteriolar smooth muscle.
McGahon MK, Dash DP, Arora A, Wall N, Dawicki J, Simpson DA, Scholfield CN, McGeown JG, Curtis TM., Free PMC Article | 01/21/2010 |
| activation of specific PKC isozymes increases BK(Ca)-channel activity in Sprague-Dawley rat PASMC via cyclic GMP-dependent protein kinase, which suggests a unique signaling mechanism for vasodilatation. | PKC activates BKCa channels in rat pulmonary arterial smooth muscle via cGMP-dependent protein kinase.
Barman SA, Zhu S, White RE. | 01/21/2010 |
| Kvbeta 1.1 contributes to the developmental control of the A-typepotassium channel current in hippocampal neurons. | Developmental regulation of the A-type potassium-channel current in hippocampal neurons: role of the Kvbeta 1.1 subunit.
Falk T, Kilani RK, Strazdas LA, Borders RS, Steidl JV, Yool AJ, Sherman SJ. | 01/21/2010 |
| DiBAC(4)(3) activated whole-cell BKalphabeta1 and BKalphabeta4 currents in the same concentration range but partially blocked BKalphabeta2 currents. Structure activity relationships are discussed. | Voltage-sensitive oxonol dyes are novel large-conductance Ca2+-activated K+ channel activators selective for beta1 and beta4 but not for beta2 subunits.
Morimoto T, Sakamoto K, Sade H, Ohya S, Muraki K, Imaizumi Y. | 01/21/2010 |
| Increased BK beta1 expression in mesenteric arteries may represent a compensatory reaction to limit the development of hypertension. | Altered expression of BK channel beta1 subunit in vascular tissues from spontaneously hypertensive rats.
Chang T, Wu L, Wang R. | 01/21/2010 |