| High plasma and lingual uroguanylin as potential contributors to changes in food preference after sleeve gastrectomy. | High plasma and lingual uroguanylin as potential contributors to changes in food preference after sleeve gastrectomy.
Frühbeck G, Becerril S, Martín M, Ramírez B, Valentí V, Moncada R, Catalán V, Gómez-Ambrosi J, Silva C, Burrell MA, Escalada J, Rodríguez A. | 03/5/2022 |
| This study investigates pro-uroguanylin circulating levels in children with obesity and its relationship with obesity, sex and pubertal development. Sexual dimorphism exists in circulating pro-uroguanylin levels with respect to Body Mass Index. | Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty.
Folgueira C, Barja-Fernández S, Gonzalez-Saenz P, Castelao C, Vázquez-Cobela R, Pena-Leon V, Ruiz-Piñon M, Casanueva FF, Dieguez C, Leis R, Nogueiras R, Seoane LM., Free PMC Article | 11/16/2019 |
| The intestinal expression of uroguanylin, a key satiety hormone, appears to be diminished in female pediatric patients in the setting of obesity. | Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity.
Di Guglielmo MD, Perdue L, Adeyemi A, van Golen KL, Corao DU., Free PMC Article | 06/1/2019 |
| In female adolescents without obesity, levels of pro-uroguanylin are higher than in those with obesity. Pro-uroguanylin secretion patterns differ from other circulating gastrointestinal peptides. In female adolescents with obesity, inflammation correlates with decreased pro-uroguanylin levels. | Pilot Study Measuring the Novel Satiety Hormone, Pro-Uroguanylin, in Adolescents With and Without Obesity.
Di Guglielmo MD, Tonb D, He Z, Adeyemi A, van Golen KL., Free PMC Article | 04/20/2019 |
| Guanylin and uroguanylin, as well as their prohormones, do not seem to play a significant role in body weight regulation and glycemic control, suggesting that guanylin-family peptides do not show promise as targets for the treatment of obesity or diabetes. | Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.
Fernandez-Cachon ML, Pedersen SL, Rigbolt KT, Zhang C, Fabricius K, Hansen HH, Elster L, Fink LN, Schäfer M, Rhee NA, Langholz E, Wandall E, Friis SU, Vilmann P, Kristiansen VB, Schmidt C, Schreiter K, Breitschopf K, Hübschle T, Jorsal T, Vilsbøll T, Schmidt T, Theis S, Knop FK, Larsen PJ, Jelsing J. | 12/29/2018 |
| Both guanylin and uroguanylin trigger lipolysis in human visceral adipocytes. Given the lipolytic action of the guanylin system on visceral adipocytes, the herein reported decrease of circulating prouroguanylin concentrations in obese patients may have a role in excessive fat accumulation in obesity. | Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes.
Rodríguez A, Gómez-Ambrosi J, Catalán V, Ezquerro S, Méndez-Giménez L, Becerril S, Ibáñez P, Vila N, Margall MA, Moncada R, Valentí V, Silva C, Salvador J, Frühbeck G. | 02/24/2018 |
| Results demonstrate that GC-C and its ligands, guanylin and uroguanylin are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C signaling pathway may be implicated in the progression of UC. | Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index.
Lan D, Niu J, Miao J, Dong X, Wang H, Yang G, Wang K, Miao Y., Free PMC Article | 01/27/2018 |
| The simulations suggested that all missense SNPs considered as convergent deleterious caused some kind of structural change to the uroguanylin peptide. Additionally, four of these SNPs were also shown to cause modifications in peptide flexibility, possibly resulting in functional changes. | Structural impact analysis of missense SNPs present in the uroguanylin gene by long-term molecular dynamics simulations.
Marcolino AC, Porto WF, Pires ÁS, Franco OL, Alencar SA. | 09/16/2017 |
| The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines. | Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.
Brenna Ø, Furnes MW, Munkvold B, Kidd M, Sandvik AK, Gustafsson BI., Free PMC Article | 05/20/2017 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesHaplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension.
Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R, Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R. [Association between uroguanylin G-247A polymorphism and blood pressure/fluid and electrolytes homeostasis].
Guo HF, Gao PJ, Li Y, Zhu DL, Wang JG. | 03/13/2008 |
| The occurrences of the C-A haplotype (rs883062-rs1047047) and the C-A-G haplotype (rs883062-rs1047047-rs2297566) were significantly higher in the essential hypertension group than in the controls. | Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension.
Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R, Yoshikawa Y, Nakayama T, Saito K, Hui P, Morita A, Sato N, Takahashi T, Tamura M, Sato I, Aoi N, Doba N, Hinohara S, Soma M, Usami R. | 01/21/2010 |
| Uroguanylin concentrations are increased in patients with chronic renal failure, nephrotic syndrome, or those on dialysis. | Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts.
Sindić A, Hirsch JR, Velic A, Piechota H, Schlatter E. | 01/21/2010 |