| An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians. | An E115A Missense Variant in CERS2 Is Associated With Increased Sleeping Energy Expenditure and Hepatic Insulin Resistance in American Indians.
Heinitz S, Traurig M, Krakoff J, Rabe P, Stäubert C, Kobes S, Hanson RL, Stumvoll M, Blüher M, Bogardus C, Baier L, Piaggi P., | 08/14/2024 |
| LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated beta-catenin dephosphorylation in a subset of stem-like bladder cancer cells. | LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells.
Shi H, Tan Z, Duan B, Guo C, Li C, Luan T, Li N, Huang Y, Chen S, Gao J, Feng W, Xu H, Wang J, Fu S, Wang H., Free PMC Article | 02/5/2024 |
| [LASS2/TMSG1 overexpression inhibits proliferation and promotes apoptosis of human lung cancer A549 cells possibly by upregulating ceramide and p38 MAPK to activate a signaling cascade]. | [LASS2/TMSG1 overexpression inhibits proliferation and promotes apoptosis of human lung cancer A549 cells possibly by upregulating ceramide and p38 MAPK to activate a signaling cascade].
Liu Z, Xuan C, Han X, Zheng Z, Xiao R, Bao L, Xu X., Free PMC Article | 03/27/2023 |
| Hsa-miR-221-3p promotes proliferation and migration in HER2-positive breast cancer cells by targeting LASS2 and MBD2. | Hsa-miR-221-3p promotes proliferation and migration in HER2-positive breast cancer cells by targeting LASS2 and MBD2.
Shao X, Zheng Y, Huang Y, Li G, Zou W, Shi L. | 12/17/2022 |
| LASS2 overexpression enhances early apoptosis of lung cancer cells through the caspasedependent pathway. | LASS2 overexpression enhances early apoptosis of lung cancer cells through the caspase‑dependent pathway.
Wang Y, Li S, Weng L, Du H, Wang J, Xu X. | 11/5/2022 |
| Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer. | Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer.
Lee WK, Maaß M, Quach A, Poscic N, Prangley H, Pallott EC, Kim JL, Pierce JS, Ogretmen B, Futerman AH, Thévenod F., Free PMC Article | 05/14/2022 |
| Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study. | Characterizing a Common CERS2 Polymorphism in a Mouse Model of Metabolic Disease and in Subjects from the Utah CAD Study.
Nicholson RJ, Poss AM, Maschek JA, Cox JE, Hopkins PN, Hunt SC, Playdon MC, Holland WL, Summers SA., Free PMC Article | 10/23/2021 |
| MicroRNA-20a Targeting LASS2 Promotes the Proliferation, Invasiveness and Migration of Bladder Cancer. | MicroRNA-20a Targeting LASS2 Promotes the Proliferation, Invasiveness and Migration of Bladder Cancer.
Xiao S, Chen Y, Luan T, Huang Y, Fu S, Zuo Y, Wang H, Wang J. | 09/18/2021 |
| Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype. | Alternative splicing of ceramide synthase 2 alters levels of specific ceramides and modulates cancer cell proliferation and migration in Luminal B breast cancer subtype.
Pani T, Rajput K, Kar A, Sharma H, Basak R, Medatwal N, Saha S, Dev G, Kumar S, Gupta S, Mukhopadhyay A, Malakar D, Maiti TK, Arimbasseri AG, Deo SVS, Sharma RD, Bajaj A, Dasgupta U., Free PMC Article | 09/18/2021 |
| Ceramide synthase 2 deletion decreases the infectivity of HIV-1. | Ceramide synthase 2 deletion decreases the infectivity of HIV-1.
Barklis E, Alfadhli A, Kyle JE, Bramer LM, Bloodsworth KJ, Barklis RL, Leier HC, Petty RM, Zelnik ID, Metz TO, Futerman AH, Tafesse FG., Free PMC Article | 08/28/2021 |
| Association of rs8444 polymorphism in the LASS2 3'-UTR and bladder cancer risk in Chinese population. | Association of rs8444 polymorphism in the LASS2 3'-UTR and bladder cancer risk in Chinese population.
Huang Y, Wang H, Fu S, Luan T, Zuo Y, Li N, Ding M, Chen Y, Wang J. | 07/10/2021 |
| Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. | Ceramide synthase 2-C(24:1) -ceramide axis limits the metastatic potential of ovarian cancer cells.
Zhang X, Sakamoto W, Canals D, Ishibashi M, Matsuda M, Nishida K, Toyoshima M, Shigeta S, Taniguchi M, Senkal CE, Okazaki T, Yaegashi N, Hannun YA, Nabe T, Kitatani K., Free PMC Article | 06/26/2021 |
| Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthase 2- and 3-Dependent Mechanisms. | Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthase 2- and 3-Dependent Mechanisms.
Shin KO, Lim CJ, Park HY, Kim S, Kim B, Lee Y, Chung H, Jeong SK, Park K, Park K. | 03/6/2021 |
| Studies indicate low level of ceramide synthase 2 (CerS-2) protein might suggest a bad prognosis and up-regulation of CerS-2 protein might act as a promising therapeutic strategy for malignant tumors [Review]. | Clinical and pathological significance of Homo sapiens ceramide synthase 2 (CerS-2) in diverse human cancers.
Zhang Q, Wang JY, Yan W, Wang DD, Yang SJ, Zhou SY, Zhong SL, Tang JH., Free PMC Article | 07/11/2020 |
| In this study, we found that LASS2 protein level was positively related to International Federation of Gynecology and Obstetrics (FIGO) stage and LASS2-negative tumors showed significant association with longer disease-free survival (DFS) and overall survival (OS) in ovarian cancer patients | High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer.
Sheng N, Wang Y, Xie Y, Chen S, Lu J, Zhang Z, Li M, Shan Q, Wu D, Zheng G, Zheng Y, Fan S. | 05/9/2020 |
| CERS2 is differentially expressed in different types of bladder cancer cell lines and the siRNA-mediated downregulation of the expression of CERS2 reduces the migratory potential of UMUC1 bladder cancer cells | Evaluation of CERS2 Gene as a Potential Biomarker for Bladder Cancer.
Aldoghachi AF, Baharudin A, Ahmad U, Chan SC, Ong TA, Yunus R, Razack AH, Yusoff K, Veerakumarasivam A., Free PMC Article | 04/18/2020 |
| The study demonstrates that miR-98 targets LASS2 and regulates bladder cancer chemoresistance through modulation of mitochondrial function. | MicroRNA-98 promotes drug resistance and regulates mitochondrial dynamics by targeting LASS2 in bladder cancer cells.
Luan T, Fu S, Huang L, Zuo Y, Ding M, Li N, Chen J, Wang H, Wang J. | 09/28/2019 |
| Data indicate that miR-3658 regulates tumor biological behavior and its downstream molecule signaling pathways through longevity assurance 2 protein (LASS2). | Hsa-miR-3658 Promotes Cell Proliferation, Migration and Invasion by Effecting LASS2 in Bladder Cancer.
Luan T, Zou R, Huang L, Li N, Fu S, Huang Y, Wang H, Wang J. | 09/21/2019 |
| Data show that mRNA expression of Cer metabolizing enzyme CERS2 was significantly increased in multiple sclerosis (MS) patients. | The relevance of ceramides and their synthesizing enzymes for multiple sclerosis.
Kurz J, Brunkhorst R, Foerch C, Blum L, Henke M, Gabriel L, Ulshöfer T, Ferreirós N, Parnham MJ, Geisslinger G, Schiffmann S. | 08/31/2019 |
| G0/G1 ratio in LASS2/TMSG1 S248A group was obviously higher than that in LASS2/TMSG1 wild group | [Novel tumor metastasis suppressorgene LASS2/TMSG1 S248A mutant promotes invasion of prostate cancer cells through increasing ATP6V0C expression].
Zhang KG, Zhou YH, Shao YK, Mei F, You JF, Liu BY, Pei F., Free PMC Article | 08/10/2019 |
| Study findings suggest that LASS2 inhibits proliferation and induces apoptosis in HepG2 hepatoblastoma cells through the mitochondrial apoptotic, NFkappaB and cell cycle signaling pathways. | LASS2 inhibits proliferation and induces apoptosis in HepG2 cells by affecting mitochondrial dynamics, the cell cycle and the nuclear factor‑κB pathways.
Yang Y, Yang X, Li L, Yang G, Ouyang X, Xiang J, Zhang T, Min X. | 06/29/2019 |
| results indicate that miR-3622a promotes the proliferation and invasion of bladder cancer cells by downregulating LASS2. | miR-3622a promotes proliferation and invasion of bladder cancer cells by downregulating LASS2.
Fu S, Luan T, Jiang C, Huang Y, Li N, Wang H, Wang J. | 05/4/2019 |
| As potential molecular markers for bladder carcinoma, both TWIST1 and LASS2 transcripts seem to play role during the tumorigenesis and development of bladder cancer. | Expression profiles of proto-oncogene TWIST1 and tumor metastasis suppressor gene LASS2 in bladder cancer.
Yegin Z, Aydin O, Koc H, Buyukalpelli R. | 12/22/2018 |
| Results show that silencing of ATP6V0C in highly metastatic prostate cancer (PC) cell lines, inhibited V-ATPase activity, which coincided with the inhibition of cell migration and invasion in vitro, as well as a marked decrease in the expression of LASS2/TMSG1 probably through positive feedback. | Silencing of vacuolar ATPase c subunit ATP6V0C inhibits the invasion of prostate cancer cells through a LASS2/TMSG1-independent manner.
Zou P, Yang Y, Xu X, Liu B, Mei F, You J, Liu Q, Pei F. | 07/21/2018 |
| CerS2-knockdown via CRISPR-Cas9 technology in cultured colon epithelial cells impaired barrier function. | Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.
Kim YR, Volpert G, Shin KO, Kim SY, Shin SH, Lee Y, Sung SH, Lee YM, Ahn JH, Pewzner-Jung Y, Park WJ, Futerman AH, Park JW., Free PMC Article | 07/14/2018 |