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    PSAT1 phosphoserine aminotransferase 1 [ Homo sapiens (human) ]

    Gene ID: 29968, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.

    Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.
    Liu Y, Xun W, Zhao T, Huang M, Sun L, Wen G, Kang X, Wang J, Han T., Free PMC Article

    10/30/2024
    PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress.

    PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress.
    Du X, Wang Y, Gao F., Free PMC Article

    10/20/2024
    PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell.

    PSAT1 Promotes Metastasis via p-AKT/SP1/ITGA2 Axis in Estrogen Receptor-Negative Breast Cancer Cell.
    Zhang X, Wang S, Li W, Wang J, Gong Y, Chen Q, Cao S, Pang D, Gao S., Free PMC Article

    09/11/2024
    Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma.

    Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma.
    Ye J, Huang X, Tian S, Wang J, Wang H, Feng H, Zhao X, Cao S, Xuan Y, Li X, Ma X, Huang Y, Zhang X.

    04/11/2024
    PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.

    PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
    Wang L, Yan F, Shi Y, Su X, Zhang Y.

    12/15/2023
    Overexpression of PSAT1 is Correlated with Poor Prognosis and Immune Infiltration in Non-Small Cell Lung Cancer.

    Overexpression of PSAT1 is Correlated with Poor Prognosis and Immune Infiltration in Non-Small Cell Lung Cancer.
    Li H, Wu C, Chang W, Zhong L, Gao W, Zeng M, Wen Z, Mai S, Chen Y.

    11/8/2023
    Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization.

    Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization.
    Marchesani F, Michielon A, Viale E, Bianchera A, Cavazzini D, Pollegioni L, Murtas G, Mozzarelli A, Bettati S, Peracchi A, Campanini B, Bruno S., Free PMC Article

    08/28/2023
    Pathogenic PSAT1 Variants and Autosomal Recessive Axonal Charcot-Marie-Tooth Disease With Ichthyosis.

    Pathogenic PSAT1 Variants and Autosomal Recessive Axonal Charcot-Marie-Tooth Disease With Ichthyosis.
    Lu Y, Xing H, Liu C, Huang D, Sun C, Yu M, Meng L, Lv H, Zhang W, Wang Z, Yuan Y, Xie Z.

    08/7/2023
    Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.

    Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.
    Peng X, Zhao L, Yao L, Dong J, Wu W, Luo T., Free PMC Article

    07/19/2023
    L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase.

    L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase.
    Marchesani F, Zangelmi E, Murtas G, Costanzi E, Ullah R, Peracchi A, Bruno S, Pollegioni L, Mozzarelli A, Storici P, Campanini B., Free PMC Article

    04/4/2023
    Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma.

    Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma.
    Wang M, Yue S, Yang Z., Free PMC Article

    03/20/2023
    Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant.

    Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant.
    Jiang J, Chen HN, Jin P, Zhou L, Peng L, Huang Z, Qin S, Li B, Ming H, Luo M, Xie N, Gao W, Nice EC, Yu Q, Huang C., Free PMC Article

    02/16/2023
    miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells.

    miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells.
    Wang H, Fang Q, You S, Wu Y, Zhang C.

    01/14/2023
    Circ_0015756 promotes ovarian cancer progression via the miR-145-5p/PSAT1 axis.

    Circ_0015756 promotes ovarian cancer progression via the miR-145-5p/PSAT1 axis.
    Pan Y, Huang Q, Peng X, Yu S, Liu N.

    12/3/2022
    Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer.

    Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer.
    Ding R, Hong W, Huang L, Shao J, Yu W, Xu X., Free PMC Article

    06/11/2022
    Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors.

    Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors.
    Choi BH, Rawat V, Högström J, Burns PA, Conger KO, Ozgurses ME, Patel JM, Mehta TS, Warren A, Selfors LM, Muranen T, Coloff JL., Free PMC Article

    02/19/2022
    Adult diagnosis of congenital serine biosynthesis defect: A treatable cause of progressive neuropathy.

    Adult diagnosis of congenital serine biosynthesis defect: A treatable cause of progressive neuropathy.
    Debs S, Ferreira CR, Groden C, Kim HJ, King KA, King MC, Lehky T, Cowen EW, Brown LH, Merideth M, Owen CM, Macnamara E, Toro C, Gahl WA, Soldatos A., Free PMC Article

    01/8/2022
    Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations.

    Phosphoserine Aminotransferase has Conserved Active Site from Microbes to Higher Eukaryotes with Minor Deviations.
    Singh RK, Kumar D, Gourinath S.

    12/25/2021
    Expanding the genotypic and phenotypic spectrum of severe serine biosynthesis disorders.

    Expanding the genotypic and phenotypic spectrum of severe serine biosynthesis disorders.
    Abdelfattah F, Kariminejad A, Kahlert AK, Morrison PJ, Gumus E, Mathews KD, Darbro BW, Amor DJ, Walsh M, Sznajer Y, Weiß L, Weidensee S, Chitayat D, Shannon P, Bermejo-Sánchez E, Riaño-Galán I, Hayes I, Poke G, Rooryck C, Pennamen P, Khung-Savatovsky S, Toutain A, Vuillaume ML, Ghaderi-Sohi S, Kariminejad MH, Weinert S, Sticht H, Zenker M, Schanze D.

    11/13/2021
    Overexpression of PSAT1 regulated by G9A sustains cell proliferation in colorectal cancer.

    Overexpression of PSAT1 regulated by G9A sustains cell proliferation in colorectal cancer.
    Wang H, Cui L, Li D, Fan M, Liu Z, Liu C, Pan S, Zhang L, Zhang H, Zhao Y., Free PMC Article

    10/9/2021
    A yeast-based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1.

    A yeast-based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1.
    Sirr A, Lo RS, Cromie GA, Scott AC, Ashmead J, Heyesus M, Dudley AM., Free PMC Article

    08/28/2021
    Long noncoding RNA MEG3 suppresses epithelialtomesenchymal transition by inhibiting the PSAT1dependent GSK3beta/Snail signaling pathway in esophageal squamous cell carcinoma.

    Long non‑coding RNA MEG3 suppresses epithelial‑to‑mesenchymal transition by inhibiting the PSAT1‑dependent GSK‑3β/Snail signaling pathway in esophageal squamous cell carcinoma.
    Li MK, Liu LX, Zhang WY, Zhan HL, Chen RP, Feng JL, Wu LF., Free PMC Article

    07/24/2021
    Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression.

    Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression.
    Barnabas GD, Lee JS, Shami T, Harel M, Beck L, Selitrennik M, Jerby-Arnon L, Erez N, Ruppin E, Geiger T., Free PMC Article

    06/26/2021
    PSAT1 Upregulation Contributes to Cell Growth and Cisplatin Resistance in Cervical Cancer Cells via Regulating PI3K/AKT Signaling Pathway.

    PSAT1 Upregulation Contributes to Cell Growth and Cisplatin Resistance in Cervical Cancer Cells via Regulating PI3K/AKT Signaling Pathway.
    Duan W, Liu X.

    05/29/2021
    Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNgamma axis.

    Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis.
    Chan YC, Chang YC, Chuang HH, Yang YC, Lin YF, Huang MS, Hsiao M, Yang CJ, Hua KT.

    11/28/2020
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