| Natural Killer Cells Disrupt Nerve Fibers by Granzyme H in Atheriosclerotic Cerebral Small Vessel Disease. | Natural Killer Cells Disrupt Nerve Fibers by Granzyme H in Atheriosclerotic Cerebral Small Vessel Disease.
Yu D, Cai W, Chen X, Lu D, Hu M, Lu T, Qin B, Wu A, Ruan H, Lu Y, Liu Z, Wei L, Lu Z. | 03/8/2023 |
| Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinoma. | Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinoma.
Ma Y, Chen X, Wang A, Zhao H, Lin Q, Bao H, Zhang Y, Hong S, Tang W, Huang Y, Yang Y, Wu X, Shao Y, Fang W, Zhang L., Free PMC Article | 12/18/2021 |
| Granzyme H did directly process DFF45, potentially leading to DNA damage. | Granzyme H induces cell death primarily via a Bcl-2-sensitive mitochondrial cell death pathway that does not require direct Bid activation.
Ewen CL, Kane KP, Bleackley RC. | 08/31/2013 |
| Upon reactive center loop cleavage at Phe-343,SERPINB1 covalently complexes with GzmH. SERPINB1 overexpression suppresses GzmH- or LAK cell-mediated cytotoxicity. Crystal structures show possible conformational changes in GzmH for the suicide inhibition. | Identification of SERPINB1 as a physiological inhibitor of human granzyme H.
Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. | 03/30/2013 |
| An unusual RKR motif (Arg39-Lys40-Arg41), conserved only in GzmH, helps define the S3' and S4' binding regions, indicating the preference for acidic residues at the P3' and P4' sites. | Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif.
Wang L, Zhang K, Wu L, Liu S, Zhang H, Zhou Q, Tong L, Sun F, Fan Z. | 02/25/2012 |
| GzmH suppresses viral replication through association with the hepatitis B virus x protein. | Granzyme H of cytotoxic lymphocytes is required for clearance of the hepatitis B virus through cleavage of the hepatitis B virus X protein.
Tang H, Li C, Wang L, Zhang H, Fan Z. | 02/25/2012 |
| Cleavage of La protein by granzyme H generates a COOH-terminal truncated form of La protein that loses nuclear localization and decreases hepatitis C virus-internal ribosome entry site-mediated translational activity. | Cleavage of La protein by granzyme H induces cytoplasmic translocation and interferes with La-mediated HCV-IRES translational activity.
Romero V, Fellows E, Jenne DE, Andrade F. | 01/21/2010 |
| GzmH may play an essential role in caspase-dependent pathogen clearance in the innate immunity that may complement the proapoptotic function of GzmB in human NK cells. | Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage.
Hou Q, Zhao T, Zhang H, Lu H, Zhang Q, Sun L, Fan Z. | 01/21/2010 |
| Granzyme H could have evolved a proteolytic specificity that both interferes directly with adenovirus replication and prevents the virus from blocking the potent pro-apoptotic activity of granzyme B. | H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells.
Waterhouse NJ, Trapani JA. | 01/21/2010 |
| Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition. | Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition.
Andrade F, Fellows E, Jenne DE, Rosen A, Young CS., Free PMC Article | 01/21/2010 |
| Expression levels of GzmH in naive natural killer cells and its killing ability support the role of the protease in triggering an alternative cell-death pathway in innate immunity. | Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program.
Fellows E, Gil-Parrado S, Jenne DE, Kurschus FC. | 01/21/2010 |
| granzyme H complements the pro-apoptotic function of granzyme B in human NK cells | Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.
Sedelies KA, Sayers TJ, Edwards KM, Chen W, Pellicci DG, Godfrey DI, Trapani JA. | 01/21/2010 |
| Granzyme C rapidly induces target cell death by attacking nuclear and mitochondrial targets and that these targets are distinct from those used by granzyme B to cause classical apoptosis. | Cell death induced by granzyme C.
Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ. | 01/21/2010 |