| De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation. | De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation.
Xie C, Zhou H, Athanasopoulos V, Shen Q, Zhang Y, Meng X, Burgio G, Arsov T, Lungu AC, Zhang P, Qin Y, Ma J, Wu X, Jiang X, Ding H, Meng Y, Shen N, He Y, Vinuesa CG. | 06/1/2023 |
| Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1. | Regulation of Synapse Weakening through Interactions of the Microtubule Associated Protein Tau with PACSIN1.
Regan P, Mitchell SJ, Kim SC, Lee Y, Yi JH, Barbati SA, Shaw C, Cho K., Free PMC Article | 12/4/2021 |
| Curvature induction and sensing of the F-BAR protein Pacsin1 on lipid membranes via molecular dynamics simulations. | Curvature induction and sensing of the F-BAR protein Pacsin1 on lipid membranes via molecular dynamics simulations.
Mahmood MI, Noguchi H, Okazaki KI., Free PMC Article | 11/21/2020 |
| PACSIN1 and EHD1 assemble membrane tubules from the developing intracellular cilium that attach to the plasma membrane, creating an extracellular membrane channel to the outside of the cell. | Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.
Insinna C, Lu Q, Teixeira I, Harned A, Semler EM, Stauffer J, Magidson V, Tiwari A, Kenworthy AK, Narayan K, Westlake CJ., Free PMC Article | 02/16/2019 |
| Specifically, CKS1B and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1, by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7. | Identification of novel human kinases that suppress hepatitis C virus infection.
Lee A, Liu S, Wang T., Free PMC Article | 10/17/2015 |
| syndapin I functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2. | ProSAP1 and membrane nanodomain-associated syndapin I promote postsynapse formation and function.
Schneider K, Seemann E, Liebmann L, Ahuja R, Koch D, Westermann M, Hübner CA, Kessels MM, Qualmann B., Free PMC Article | 06/14/2014 |
| Data indicate that the structural capacity of N17 to fold back toward distal regions within huntingtin requires an interacting protein, protein kinase C and casein kinase 2 substrate in neurons 1 (PACSIN1). | Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.
Caron NS, Desmond CR, Xia J, Truant R., Free PMC Article | 12/21/2013 |
| Pacsin-1 plays a versatile role in sculpting cellular membranes that is likely dependent both on protein structure and membrane properties. | Versatile membrane deformation potential of activated pacsin.
Goh SL, Wang Q, Byrnes LJ, Sondermann H., Free PMC Article | 06/15/2013 |
| PACSIN1 represents a pDC-specific adaptor molecule that plays an important role in the TLR7/9-mediated type I IFN responses by pDCs in vitro and in vivo. | PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells.
Esashi E, Bao M, Wang YH, Cao W, Liu YJ., Free PMC Article | 07/21/2012 |
| Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation | Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation.
Quan A, Xue J, Wielens J, Smillie KJ, Anggono V, Parker MW, Cousin MA, Graham ME, Robinson PJ., Free PMC Article | 05/5/2012 |
| PACSIN 1 (1-344) was crystallized & diffracted to resolution of 3.0 A. The crystal belonged to space group C2, with unit-cell parameters a=158.65, b=87.38, c=91.76 A, alpha=90.00, beta=113.61, gamma=90.00 degrees. There are 2 molecules in asymmetric unit. | Crystallization and preliminary X-ray crystallographic analysis of human PACSIN 1 protein.
Bai X, Meng G, Li G, Luo M, Zheng X., Free PMC Article | 03/29/2010 |
| The regulated deformation of membranes and promotion of tubule constrictions by Pacsin suggests a more versatile function of these proteins in vesiculation and endocytosis. | Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.
Wang Q, Navarro MV, Peng G, Molinelli E, Goh SL, Judson BL, Rajashankar KR, Sondermann H., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.
Ng D, Hu N, Hu Y, Wang C, Giffen C, Tang ZZ, Han XY, Yang HH, Lee MP, Goldstein AM, Taylor PR., Free PMC Article | 09/24/2008 |