| E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis. | E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis.
Ahmed SF, Buetow L, Gabrielsen M, Lilla S, Sibbet GJ, Sumpton D, Zanivan S, Hedley A, Clark W, Huang DT., Free PMC Article | 10/16/2021 |
| High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma. | High expression of CIN85 promotes proliferation and invasion of human esophageal squamous cell carcinoma.
Hua XY, Bie XX, Cheng X, Zhang SG., Free PMC Article | 05/1/2021 |
| In Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain. | In Silico Identification of Potential Druggable Binding Sites on CIN85 SH3 Domain.
Vittorio S, Seidel T, Garon A, Gitto R, Langer T, De Luca L., Free PMC Article | 04/3/2021 |
| The three N-terminal SH3 domains of CIN85 bind to the N-terminus of PHD2. | The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.
Kozlova N, Mennerich D, Samoylenko A, Dimova EY, Koivunen P, Biterova E, Richter K, Hassinen A, Kellokumpu S, Manninen A, Miinalainen I, Glumoff V, Ruddock L, Drobot LB, Kietzmann T. | 06/20/2020 |
| These results reveal nonredundant functions of CIN85 for humoral immune responses. | Germline deletion of CIN85 in humans with X chromosome-linked antibody deficiency.
Keller B, Shoukier M, Schulz K, Bhatt A, Heine I, Strohmeier V, Speckmann C, Engels N, Warnatz K, Wienands J., Free PMC Article | 06/22/2019 |
| These studies demonstrate a requirement for human herpesvirus 5 pUL135 interactions with Abi-1 and CIN85 for regulation of EGFR and mechanistically link the regulation of EGFR to virus reactivation. | Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.
Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F., Free PMC Article | 03/30/2019 |
| Transcriptional regulation of NOX genes expression in human breast adenocarcinoma cells is modulated by adaptor protein CIN85. | Transcriptional regulation of NOX genes express ion in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN 85.
Bazalii AV, Horak IR, Pasi chn yk GV, Komisarenko SV, Drobot LB. | 01/20/2018 |
| The multiple Src homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP-65 molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process. | The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation.
Kühn J, Wong LE, Pirkuliyeva S, Schulz K, Schwiegk C, Fünfgeld KG, Keppler S, Batista FD, Urlaub H, Habeck M, Becker S, Griesinger C, Wienands J. | 11/25/2017 |
| these data support a role for the novel PP2Ac-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity. | A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in αIIbβ3 Integrin Signaling.
Khatlani T, Pradhan S, Da Q, Shaw T, Buchman VL, Cruz MA, Vijayan KV., Free PMC Article | 05/7/2017 |
| CIN85 promotes recycling of TGF-beta receptors and thereby positively regulates TGF-beta signaling. | CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.
Yakymovych I, Yakymovych M, Zang G, Mu Y, Bergh A, Landström M, Heldin CH., Free PMC Article | 04/30/2016 |
| we demonstrate that SEPT9 negatively regulates EGFR degradation by preventing the association of the ubiquitin ligase Cbl with CIN85, resulting in reduced EGFR ubiquitylation | SEPT9 negatively regulates ubiquitin-dependent downregulation of EGFR.
Diesenberg K, Beerbaum M, Fink U, Schmieder P, Krauss M. | 03/5/2016 |
| Results support the model that Cbl-CIN85-endophilin complex is not required for efficient internalization of EGFR, a prototype RTK. | Cbl-family ubiquitin ligases and their recruitment of CIN85 are largely dispensable for epidermal growth factor receptor endocytosis.
Ahmad G, Mohapatra BC, Schulte NA, Nadeau SA, Luan H, Zutshi N, Tom E, Ortega-Cava C, Tu C, Sanada M, Ogawa S, Toews ML, Band V, Band H., Free PMC Article | 09/26/2015 |
| Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma cell line. | Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma MCF-7 cells.
Vynnytska-Myronovska BO, Bobak YP, Pasichnyk GV, Igumentseva NI, Samoylenko AA, Drobot LB. | 04/18/2015 |
| LOX-PP interacts with CIN85 via a novel SH3-binding motif and this association reduces CIN85-promoted invasion by breast cancer cells. | Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.
Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE., Free PMC Article | 05/31/2014 |
| an FRS2beta-CIN85/CD2AP-Cbl axis for downregulation of ErbB2 may regulate ErbB2 protein levels in physiological and pathological settings | Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation.
Minegishi Y, Shibagaki Y, Mizutani A, Fujita K, Tezuka T, Kinoshita M, Kuroda M, Hattori S, Gotoh N., Free PMC Article | 04/27/2013 |
| Data show that EGFR activation leads to a pronounced src-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination. | CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies.
Schroeder B, Srivatsan S, Shaw A, Billadeau D, McNiven MA., Free PMC Article | 03/9/2013 |
| this study indicates that high levels of Ruk(l)/CIN85 contribute to the conversion of breast adenocarcinoma cells into a more malignant phenotype via modulation of the Src/Akt pathway. | Increased levels of the HER1 adaptor protein Rukl/CIN85 contribute to breast cancer malignancy.
Samoylenko A, Vynnytska-Myronovska B, Byts N, Kozlova N, Basaraba O, Pasichnyk G, Palyvoda K, Bobak Y, Barska M, Mayevska O, Rzhepetsky Y, Shuvayeva H, Lyzogubov V, Usenko V, Savran V, Volodko N, Buchman V, Kietzmann T, Drobot L. | 01/26/2013 |
| Data show that CIN85 (c-Cbl interacting protein of 85 kDa) is constitutively associated with c-Cbl, Cbl-b, and B-cell linker in B cells. | CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.
Niiro H, Jabbarzadeh-Tabrizi S, Kikushige Y, Shima T, Noda K, Ota S, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, Akashi K. | 05/26/2012 |
| Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction. | The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.
Oellerich T, Bremes V, Neumann K, Bohnenberger H, Dittmann K, Hsiao HH, Engelke M, Schnyder T, Batista FD, Urlaub H, Wienands J., Free PMC Article | 11/5/2011 |
| The CIN85 was constitutively associated with Hrs, and this strengthens the hypothesis of a functional role of CIN85 in endosomal EGFR sorting. | CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor.
Rønning SB, Pedersen NM, Madshus IH, Stang E. | 09/3/2011 |
| the ubiquitination and degradation of stimulated FcgammaRIIa mediated by c-Cbl are positively regulated by the adaptor protein CIN85 in a PKC-dependent manner and these events contribute to the termination of FcgammaRIIa signaling. | CIN85 modulates the down-regulation of Fc gammaRIIa expression and function by c-Cbl in a PKC-dependent manner in human neutrophils.
Marois L, Vaillancourt M, Paré G, Gagné V, Fernandes MJ, Rollet-Labelle E, Naccache PH., Free PMC Article | 07/16/2011 |
| the N- and C-termini are important for the structure, stability, and function of the third SH3 domain of CIN85 | Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85.
Philippe D, Ababou A, Yang X, Ghosh R, Daviter T, Ladbury JE, Pfuhl M. | 07/16/2011 |
| ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking. | ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.
Yoon HY, Kales SC, Luo R, Lipkowitz S, Randazzo PA., Free PMC Article | 07/16/2011 |
| High CIN85 is associated with the development and progression of head and neck squamous cell carcinoma. | A critical role of c-Cbl-interacting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas through the ras-ERK pathway.
Wakasaki T, Masuda M, Niiro H, Jabbarzadeh-Tabrizi S, Noda K, Taniyama T, Komune S, Akashi K., Free PMC Article | 02/5/2011 |
| CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4 | Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.
Kedar VP, Darby MK, Williams JG, Blackshear PJ., Free PMC Article | 01/15/2011 |