| Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. | Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
Bhandari SK, Wiest N, Sallmyr A, Du R, Ferry L, Defossez PA, Tomkinson AE., Free PMC Article | 04/4/2023 |
| Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0. | Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0.
Lubin E, Bryant L, Aicher J, Li D, Bhoj E. | 08/6/2022 |
| Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges. | Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges.
Martinsen JH, Saar D, Fernandes CB, Schuler B, Bugge K, Kragelund BB., Free PMC Article | 04/16/2022 |
| Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome. | Linker histone defines structure and self-association behaviour of the 177 bp human chromatosome.
Wang S, Vogirala VK, Soman A, Berezhnoy NV, Liu ZB, Wong ASW, Korolev N, Su CJ, Sandin S, Nordenskiöld L., Free PMC Article | 09/4/2021 |
| The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array. | The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array.
Woods DC, Rodríguez-Ropero F, Wereszczynski J., Free PMC Article | 06/19/2021 |
| Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture. | Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
Yusufova N, Kloetgen A, Teater M, Osunsade A, Camarillo JM, Chin CR, Doane AS, Venters BJ, Portillo-Ledesma S, Conway J, Phillip JM, Elemento O, Scott DW, Béguelin W, Licht JD, Kelleher NL, Staudt LM, Skoultchi AI, Keogh MC, Apostolou E, Mason CE, Imielinski M, Schlick T, David Y, Tsirigos A, Allis CD, Soshnev AA, Cesarman E, Melnick AM., Free PMC Article | 02/27/2021 |
| Histone H1 acetylation at lysine 85 (H1K85) mutation leads to genomic instability and decreased cell survival upon DNA damage. | Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.
Li Y, Li Z, Dong L, Tang M, Zhang P, Zhang C, Cao Z, Zhu Q, Chen Y, Wang H, Wang T, Lv D, Wang L, Zhao Y, Yang Y, Wang H, Zhang H, Roeder RG, Zhu WG., Free PMC Article | 08/31/2019 |
| Measure the binding affinity for the prothymosin-alpha (ProTalpha)-H1.0 complex using isothermal titration calorimetry and report a KD value of (4.6 +/- 0.5) x 10(-7) M. In addition, we show that ProTalpha facilitates the formation of the H1.0-nucleosome complex in vitro. | Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTα.
Feng H, Zhou BR, Bai Y., Free PMC Article | 08/3/2019 |
| H1.X moves more rapidly than other linker histones in vivo Domain swapping between H1.0 and H1.X suggests that the globular domain (GD) and C-terminal domain (CTD) of H1.X independently contribute to the dynamic behavior of H1.X. | Regulation of Cellular Dynamics and Chromosomal Binding Site Preference of Linker Histones H1.0 and H1.X.
Okuwaki M, Abe M, Hisaoka M, Nagata K., Free PMC Article | 06/24/2017 |
| this study shows that dynamic epigenetic states defined by the linker histone H1.0 determine which cells within a tumor can sustain the long-term cancer growth. | The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.
Torres CM, Biran A, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben-Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E, Scaffidi P., Free PMC Article | 04/1/2017 |
| The N-terminal domain contributes toward the differential chromatin binding affinity, whereas the C-terminal domain contributes toward distinct nucleosomal interface of isotypes H10 and H1c. | N- and C-terminal domains determine differential nucleosomal binding geometry and affinity of linker histone isotypes H1(0) and H1c.
Vyas P, Brown DT., Free PMC Article | 06/9/2012 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)., Free PMC Article | 09/15/2010 |
| nuclear transport of H1 histones requires a heterodimeric nuclear import receptor | The requirement of H1 histones for a heterodimeric nuclear import receptor.
Bäuerle M, Doenecke D, Albig W. | 01/21/2010 |
| H1(0)histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression. | H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors.
Gabrilovich DI, Cheng P, Fan Y, Yu B, Nikitina E, Sirotkin A, Shurin M, Oyama T, Adachi Y, Nadaf S, Carbone DP, Skoultchi AI. | 01/21/2010 |