| Tiam1 plays a critical role in the development of glutamatergic perforant path-dentae gyrus synapses. | Tiam1 is Critical for Glutamatergic Synapse Structure and Function in the Hippocampus.
Rao S, Kay Y, Herring BE., Free PMC Article | 07/4/2020 |
| We show that Rac1 and the Rac guanine nucleotide exchange factor (GEF) Tiam1 are differentially activated by oxygen-glucose deprivation in hippocampal and cortical neurons. | Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
Blanco-Suárez E, Fiuza M, Liu X, Chakkarapani E, Hanley JG., Free PMC Article | 02/7/2015 |
| our result suggests a critical role of NMDAR in regulation of oligodendrocyte precursor cells migration during CNS development by coupling to and activating the Tiam1/Rac1 pathway. | NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration.
Xiao L, Hu C, Yang W, Guo D, Li C, Shen W, Liu X, Aijun H, Dan W, He C. | 06/21/2014 |
| MAP1B interacts with a guanine exchange factor, termed Tiam1, which specifically activates Rac1. | The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells.
Henríquez DR, Bodaleo FJ, Montenegro-Venegas C, González-Billault C., Free PMC Article | 06/29/2013 |
| Tiam1 mediates TrkA signaling and neurite outgrowth induced by NGF | Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth.
Shirazi Fard S, Kele J, Vilar M, Paratcha G, Ledda F., Free PMC Article | 01/15/2011 |
| siRNA-mediated knock-down of Tiam1 markedly inhibited glucose-induced membrane trafficking and activation of Rac1. | Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.
Veluthakal R, Madathilparambil SV, McDonald P, Olson LK, Kowluru A., Free PMC Article | 01/21/2010 |
| Tiam1, a Rac1-specific guanine nucleotide exchange factor, was expressed mainly in the cytosol of AT2 cells exposed to mechanical strain compared with membrane localization in static cells. | Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.
Desai LP, Chapman KE, Waters CM., Free PMC Article | 01/21/2010 |
| 16k PRL inhibits cell migration by blocking the Ras-Tiam1-Rac1-Pak1 signaling pathway in endothelial cells | 16-kDa prolactin inhibits endothelial cell migration by down-regulating the Ras-Tiam1-Rac1-Pak1 signaling pathway.
Lee SH, Kunz J, Lin SH, Yu-Lee LY. | 01/21/2010 |
| Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. | Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration.
Yamauchi J, Miyamoto Y, Tanoue A, Shooter EM, Chan JR., Free PMC Article | 01/21/2010 |
| PAR-6-PAR-3 complex mediates Cdc42-induced Rac activation by means of STEF/Tiam1 | PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuchi K. | 01/21/2010 |
| These findings suggest that EphBs regulate spine development in part by recruiting, phosphorylating, and activating Tiam1. | The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development.
Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME., Free PMC Article | 01/21/2010 |
| BDNF, acting through Neural receptor protein-tyrosine kinase (trkB), directly binds and specifically activates Tiam1 by phosphorylating Tyr-829, leading to small GTP binding protein Rac1 activation and lamellipodia formation | TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.
Miyamoto Y, Yamauchi J, Tanoue A, Wu C, Mobley WC., Free PMC Article | 01/21/2010 |
| A balance of PAR-3 and TIAM1 is essential to modulate Rac-GTP levels and to allow spine morphogenesis. | The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis.
Zhang H, Macara IG. | 01/21/2010 |
| N-terminal region of both proteins binds to the scaffold protein IB2/JIP2. IB2/JIP2 is a scaffold for the p38 mitogen-activated protein (MAP) kinase cascade because it binds to the Rac target MLK3. | Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade.
Buchsbaum RJ, Connolly BA, Feig LA., Free PMC Article | 01/21/2010 |