| MEF2C contributes to axonal branching by regulating Kif2c transcription. | MEF2C contributes to axonal branching by regulating Kif2c transcription.
Wu R, Sun Y, Zhou Z, Dong Z, Liu Y, Liu M, Gao H. | 09/30/2024 |
| mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour. | mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour.
Adrião A, Mariano S, Mariano J, Gavaia PJ, Cancela ML, Vitorino M, Conceição N., Free PMC Article | 06/2/2023 |
| Variable paralog expression underlies phenotype variation. | Variable paralog expression underlies phenotype variation.
Bailon-Zambrano R, Sucharov J, Mumme-Monheit A, Murry M, Stenzel A, Pulvino AT, Mitchell JM, Colborn KL, Nichols JT., Free PMC Article | 10/22/2022 |
| Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle. | Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle.
Kula-Alwar D, Marber MS, Hughes SM, Hinits Y., Free PMC Article | 04/24/2021 |
| Strikingly, our selective breeding for low penetrance converted the mef2ca mutant allele behavior from homozygous lethal to homozygous viable. Meanwhile, selective breeding for high penetrance converted the mef2ca mutant allele from fully recessive to partially dominant. | Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway.
Sucharov J, Ray K, Brooks EP, Nichols JT., Free PMC Article | 02/29/2020 |
| variable transposon epigenetic silencing underlies the variable mef2ca mutant bone phenotype, and could be a widespread mechanism of phenotypic variability in animals. | Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca.
Nichols JT, Blanco-Sánchez B, Brooks EP, Parthasarathy R, Dowd J, Subramanian A, Nachtrab G, Poss KD, Schilling TF, Kimmel CB., Free PMC Article | 09/16/2017 |
| Mef2 controls skeletal muscle formation after terminal differentiation. | Mef2s are required for thick filament formation in nascent muscle fibres.
Hinits Y, Hughes SM., Free PMC Article | 11/4/2016 |
| Our study provides new insights in MEF2C conservation and provides the first evidence of mef2cb regulation by both transcriptional and post transcriptional mechanisms. | MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation.
Adrião A, Conceição N, Cancela ML. | 06/28/2016 |
| mef2ca transcripts including exon 5 (mef2ca 4-5-6) are present early in the embryo. Over-expression of this isoform alters the expression of genes involved in early dorso-ventral patterning of the embryo and induces severe developmental defects | Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb.
Ganassi M, Badodi S, Polacchini A, Baruffaldi F, Battini R, Hughes SM, Hinits Y, Molinari S., Free PMC Article | 09/13/2014 |
| By selectively inhibiting translational initiation of mef2ca and other mRNAs, eIF4EBP3L reprograms the translational profile of muscle, enabling it to adjust to new environmental conditions. | eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation.
Yogev O, Williams VC, Hinits Y, Hughes SM., Free PMC Article | 05/10/2014 |
| find no evidence that the phenotypic stability in the wild type is provided by redundancy between mef2ca and its co-ortholog mef2cb, or that it is related to the selector (homeotic) gene function of mef2ca | Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton.
DeLaurier A, Huycke TR, Nichols JT, Swartz ME, Larsen A, Walker C, Dowd J, Pan L, Moens CB, Kimmel CB., Free PMC Article | 03/8/2014 |
| Mef2ca single mutants have delayed heart development, but form an apparently normal heart. Mef2cb single mutants have a functional heart and are viable adults. | Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation.
Hinits Y, Pan L, Walker C, Dowd J, Moens CB, Hughes SM., Free PMC Article | 11/3/2012 |
| the genetic interaction of Tbx5 and Mef2c is not only required for MYH6 expression but also essential for the early stages of heart development and survival | Physical interaction between TBX5 and MEF2C is required for early heart development.
Ghosh TK, Song FF, Packham EA, Buxton S, Robinson TE, Ronksley J, Self T, Bonser AJ, Brook JD., Free PMC Article | 01/21/2010 |