| Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell. | Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.
Guo X, Wen J, Gao Q, Zhao Y, Zhao Y, Wang C, Xu N, Shao Y, Chang X. | 11/16/2023 |
| Internal and external modulation factors of the orexin system (REVIEW). | Internal and external modulation factors of the orexin system (REVIEW).
Maruyama T, Ueta Y. | 06/2/2023 |
| Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway. | Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.
Xu D, Kong T, Zhang S, Cheng B, Chen J, Wang C. | 01/22/2022 |
| Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study. | Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.
Goldstein N, Tsuneki H, Bhandarkar N, Aimaretti E, Haim Y, Kon K, Sato K, Wada T, Liberty IF, Kirshtein B, Dukhno O, Maixner N, Gepner Y, Sasaoka T, Rudich A. | 12/25/2021 |
| Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation. | Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.
Vitale RM, Iannotti FA, Schiano Moriello A, Tunisi L, Piscitelli F, Savopoulos R, Cristino L, De Petrocellis L, Amodeo P, Gray R, Di Marzo V., Free PMC Article | 10/2/2021 |
| Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender. | Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.
Pulver A, Kiive E, Kanarik M, Harro J. | 10/2/2021 |
| Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients. | Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.
Hu S, Niu J, Zhang R, Li X, Luo M, Sang T, Guo J, Liu J, Ding X, Li X, Ma Y, Gao R. | 05/15/2021 |
| TM4 and 5 of APJ act as the interaction interface of the APJ-OX1R heterodimer, and co-internalization could be disrupted by these peptides as well. | Transmembrane peptide 4 and 5 of APJ are essential for its heterodimerization with OX1R.
Wan L, Xu F, Liu C, Ji B, Zhang R, Wang P, Wu F, Pan Y, Yang C, Wang C, Chen J. | 08/1/2020 |
| Study shows that homozygocity for the minor variant of the HCRTR1 gene (rs2271933, G1222A) that causes amino acid substitution (Ile408Val) was associated with aggressiveness measured with either self-reports or clinical interviews. | Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour.
Harro J, Laas K, Eensoo D, Kurrikoff T, Sakala K, Vaht M, Parik J, Mäestu J, Veidebaum T. | 06/13/2020 |
| A significant interaction effect between GHRL rs696217 and HCRTR1 rs2271933 was found to predict the Post-traumatic stress disorder symptoms Checklist (PCL-5) total score (P = 0.007). | The preliminary investigation of orexigenic hormone gene polymorphisms on posttraumatic stress disorder symptoms.
Li G, Zhang K, Wang L, Cao C, Fang R, Liu P, Luo S, Liberzon I. | 03/28/2020 |
| Orx1 rs10914456 variants may affect depressive symptom severity. | Orexin/hypocretin receptor, Orx(1), gene variants are associated with major depressive disorder.
Cengiz M, Karaj V, Kocabasoğlu N, Gozubatik-Celik G, Dirican A, Bayoglu B. | 12/14/2019 |
| Silence of OX1R completely abolished the inhibitory function of orexin in attachment of THP-1 cells. Collectively, our data suggest that orexin A ameliorated endothelial dysfunction under inflammatory stimuli. | Orexin A Suppresses Oxidized LDL Induced Endothelial Cell Inflammation via MAPK p38 and NF-κB Signaling Pathway.
Zhang H, Liang B, Li T, Zhou Y, Shang D, Du Z. | 08/3/2019 |
| Involvement of HCRTR1 gene variation in the etiology of panic disorder/agoraphobia and related traits as well as treatment response to CBT. | Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.
Gottschalk MG, Richter J, Ziegler C, Schiele MA, Mann J, Geiger MJ, Schartner C, Homola GA, Alpers GW, Büchel C, Fehm L, Fydrich T, Gerlach AL, Gloster AT, Helbig-Lang S, Kalisch R, Kircher T, Lang T, Lonsdorf TB, Pané-Farré CA, Ströhle A, Weber H, Zwanzger P, Arolt V, Romanos M, Wittchen HU, Hamm A, Pauli P, Reif A, Deckert J, Neufang S, Höfler M, Domschke K., Free PMC Article | 06/24/2019 |
| Activation of orexin system facilitates anesthesia emergence and pain control. | Activation of orexin system facilitates anesthesia emergence and pain control.
Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY., Free PMC Article | 05/4/2019 |
| Study provides the first demonstration that OX1R is aberrantly expressed in the inflamed mucosa of ulcerative colitis patients, both in the epithelial and immune cells. | Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A.
Messal N, Fernandez N, Dayot S, Gratio V, Nicole P, Prochasson C, Chantret I, LeGuilloux G, Jarry A, Couvelard A, Tréton X, Voisin T, Ogier-Denis E, Couvineau A. | 12/22/2018 |
| In this study we demonstrate a new role of MRAP2 in the regulation of the orexin receptor 1 (OX1R) and identify the specific regions of MRAP2 required for the regulation of OX1R and PKR1. Importantly, like MC4R and PKRs, OX1R is predominately expressed in the brain where it regulates food intake | Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling.
Rouault AAJ, Lee AA, Sebag JA. | 02/10/2018 |
| After sequencing all orexin receptor exons, one variation (rs2271933) in the OX1R gene and one variation (rs2653349) in the OX2R gene were found. However, no significant differences were found in either genotypic or allelic frequency distributions between the two study groups | Increased plasma orexin-A levels in patients with insomnia disorder are not associated with prepro-orexin or orexin receptor gene polymorphisms.
Tang S, Huang W, Lu S, Lu L, Li G, Chen X, Liu X, Lv X, Zhao Z, Duan R, Du Y, Tang J. | 12/2/2017 |
| G-protein-dependency of OX1 receptor signalling | G-protein-dependency of orexin/hypocretin receptor signalling in recombinant Chinese hamster ovary cells.
Kukkonen JP. | 05/27/2017 |
| Several single nucleotide polymorphisms (SNPs) in HCRTR2 were nominally associated with Antipsychotic-induced weight gain (AIWG) in patients of European ancestry treated with either clozapine or olanzapine. None of the SNPs in HCRTR1 were associated with AIWG. | Association of orexin receptor polymorphisms with antipsychotic-induced weight gain.
Tiwari AK, Brandl EJ, Zai CC, Goncalves VF, Chowdhury NI, Freeman N, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ. | 05/27/2017 |
| Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR1 gene. | Absence of mutations in HCRT, HCRTR1 and HCRTR2 in patients with ROHHAD.
Barclay SF, Rand CM, Gray PA, Gibson WT, Wilson RJ, Berry-Kravis EM, Ize-Ludlow D, Bech-Hansen NT, Weese-Mayer DE. | 12/3/2016 |
| This study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution. | Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors.
Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM. | 09/17/2016 |
| the orexinA/OX1 receptor axis has a significant pro-survival function in adrenal cells. | Orexin-A regulates cell apoptosis in human H295R adrenocortical cells via orexin receptor type 1 through the AKT signaling pathway.
Chang X, Zhao Y, Ju S, Guo L. | 09/3/2016 |
| OX1R signaling can attenuate KOR-mediated reduction of cellular cAMP levels while enhancing KOR-mediated beta-arrestin recruitment and p38 activation. | The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism.
Robinson JD, McDonald PH., Free PMC Article | 02/20/2016 |
| OX1R and KOR heterodimerize, and this heterodimer associates with Galphas, leading to increased protein kinase A (PKA) signaling pathway activity, including upregulation of intracellular cAMP levels. | Heterodimerization of human orexin receptor 1 and kappa opioid receptor promotes protein kinase A/cAMP-response element binding protein signaling via a Gαs-mediated mechanism.
Chen J, Zhang R, Chen X, Wang C, Cai X, Liu H, Jiang Y, Liu C, Bai B. | 02/20/2016 |
| Results from homology and docking modeling show two alternative binding modes for orexin-A into orexin 1 receptor in concordance with what is known of G protein coupled receptors activation in general and the mutational data. | Modeling of the OX1R-orexin-A complex suggests two alternative binding modes.
Karhu L, Turku A, Xhaard H., Free PMC Article | 01/23/2016 |