| Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway. | Bmp4 in Zebrafish Enhances Antiviral Innate Immunity through p38 MAPK (Mitogen-Activated Protein Kinases) Pathway.
Chen L, Zhong S, Wang Y, Wang X, Liu Z, Hu G., Free PMC Article | 11/7/2023 |
| lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway. | lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway.
Sun L, Ping L, Gao R, Zhang B, Chen X., Free PMC Article | 08/9/2023 |
| Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish. | Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish.
Bulk J, Kyrychenko V, Rensinghoff PM, Ghaderi Ardekani Z, Heermann S., Free PMC Article | 06/7/2023 |
| pouC binds a bmp4 intronic regulatory element to mediate transcriptional activation | pouC Regulates Expression of bmp4 During Atrioventricular Canal Formation in Zebrafish.
Bhakta M, Padanad MS, Harris JP, Lubczyk C, Amatruda JF, Munshi NV., Free PMC Article | 08/3/2019 |
| Structures of Bmp2a, Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved. | Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives.
Marques CL, Fernández I, Viegas MN, Cox CJ, Martel P, Rosa J, Cancela ML, Laizé V., Free PMC Article | 06/28/2016 |
| FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a. | FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway.
Pouget C, Peterkin T, Simões FC, Lee Y, Traver D, Patient R., Free PMC Article | 10/31/2015 |
| we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart | Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry.
Lenhart KF, Holtzman NG, Williams JR, Burdine RD., Free PMC Article | 06/1/2013 |
| Results show that BMP4 down-regulates fshr while up-regulating lhr expression. | Differential regulation of gonadotropin receptors by bone morphogenetic proteins in the zebrafish ovary.
Li CW, Zhou R, Ge W. | 11/17/2012 |
| These data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis. | LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.
Pi X, Schmitt CE, Xie L, Portbury AL, Wu Y, Lockyer P, Dyer LA, Moser M, Bu G, Flynn EJ 3rd, Jin SW, Patterson C., Free PMC Article | 11/3/2012 |
| Id2a and Bmp4 misexpression resulted in similar ectomesenchyme defects;misexpression of Bmp4 in migrating Cranial neural crest cells inhibits ectomesenchyme formation. | Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest.
Das A, Crump JG., Free PMC Article | 09/29/2012 |
| Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC | Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2.
Verhoeven MC, Haase C, Christoffels VM, Weidinger G, Bakkers J. | 12/10/2011 |
| identify Npnt as a novel upstream regulator of Bmp4-Has2 signaling that plays a crucial role in AV canal differentiation | Nephronectin regulates atrioventricular canal differentiation via Bmp4-Has2 signaling in zebrafish.
Patra C, Diehl F, Ferrazzi F, van Amerongen MJ, Novoyatleva T, Schaefer L, Mühlfeld C, Jungblut B, Engel FB., Free PMC Article | 12/3/2011 |
| immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development | Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.
Smith KA, Lagendijk AK, Courtney AD, Chen H, Paterson S, Hogan BM, Wicking C, Bakkers J. | 11/26/2011 |
| Elimination of function of bmp2b and bmp4 singly and in combination did not prevent the formation of mature, attached teeth. | bmp2b and bmp4 are dispensable for zebrafish tooth development.
Wise SB, Stock DW. | 03/19/2011 |
| BMP has a role in regulation of myogenesis in zebrafish | BMP regulation of myogenesis in zebrafish.
Patterson SE, Bird NC, Devoto SH., Free PMC Article | 12/11/2010 |
| Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate proepicardial organ development. | Tbx5 and Bmp signaling are essential for proepicardium specification in zebrafish.
Liu J, Stainier DY., Free PMC Article | 07/26/2010 |
| While continued Hedgehog (Hh) signaling from the overlying midline structures maintains the arterial program characteristic of the dorsal aorta (DA) roof, a ventral Bmp4 signal induces the blood stem cell program in the DA floor. | Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta.
Wilkinson RN, Pouget C, Gering M, Russell AJ, Davies SG, Kimelman D, Patient R., Free PMC Article | 01/21/2010 |
| These results illustrate a role for Bmp4 in the proliferation and timely differentiation of axial tissue after dorsoventral axis specification. | Tailbud-derived Bmp4 drives proliferation and inhibits maturation of zebrafish chordamesoderm.
Esterberg R, Delalande JM, Fritz A., Free PMC Article | 01/21/2010 |
| TCDD altered the localized expression of mRNAs bmp4 and nothch1b normally associated with developing heart valves in zebrafish. | 2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure prevents cardiac valve formation in developing zebrafish.
Mehta V, Peterson RE, Heideman W., Free PMC Article | 01/21/2010 |
| Data indicate that BMP4 plays an important role in the development of protrusions to form semicircular canals. | Role of Bone morphogenetic protein 4 in zebrafish semicircular canal development.
Omata Y, Nojima Y, Nakayama S, Okamoto H, Nakamura H, Funahashi J. | 01/21/2010 |
| precise amount and/or timing of Wnt/beta-catenin signaling is required for proper heart tube formation and cardiac looping | Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.
Klaus A, Saga Y, Taketo MM, Tzahor E, Birchmeier W., Free PMC Article | 01/21/2010 |
| BMP4 is required during the later phase of BMP signaling for the specification of ventroposterior cell fates | Zebrafish bmp4 functions during late gastrulation to specify ventroposterior cell fates.
Stickney HL, Imai Y, Draper B, Moens C, Talbot WS., Free PMC Article | 01/21/2010 |
| The 7.5-kb BMP4 promoter/proximal upstream region specifically contains regulatory elements for BMP4 expression in the heart, while regulatory elements for other endogenous BMP4-expressing tissues may reside in more distal regions and/or in introns. | Proximal upstream region of zebrafish bone morphogenetic protein 4 promoter directs heart expression of green fluorescent protein.
Shentu H, Wen HJ, Her GM, Huang CJ, Wu JL, Hwang SP. | 01/21/2010 |
| GATA-6 maintains BMP-4 expression during cardiomyocyte precursor maturation. | GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation.
Peterkin T, Gibson A, Patient R., Free PMC Article | 01/21/2010 |
| Expressed in Kupffer's vesicle; restricted knock down of bmp4 in this structure results in left-right patterning defects. | Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points.
Chocron S, Verhoeven MC, Rentzsch F, Hammerschmidt M, Bakkers J. | 01/21/2010 |