| The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis. | The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis.
Li Y, Gao J, Zhao D, Guan X, Morris SC, Finkelman FD, Huang H., Free PMC Article | 07/10/2023 |
| Correlation between histidine decarboxylase expression of keratinocytes and visual analogue scale in patients with atopic dermatitis. | Correlation between histidine decarboxylase expression of keratinocytes and visual analogue scale in patients with atopic dermatitis.
Inami Y, Fukushima M, Murota H. | 01/29/2022 |
| Expression of histidine decarboxylase in melanocytes of the human skin. | Expression of histidine decarboxylase in melanocytes of the human skin.
Inami Y, Fukushima M, Murota H. | 04/24/2021 |
| Study of the antitumour effects and the modulation of immune response by histamine in breast cancer. | Study of the antitumour effects and the modulation of immune response by histamine in breast cancer.
Nicoud MB, Sterle HA, Massari NA, Táquez Delgado MA, Formoso K, Herrero Ducloux MV, Martinel Lamas D, Cremaschi GA, Medina VA., Free PMC Article | 10/24/2020 |
| Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review] | Structural and functional analogies and differences between histidine decarboxylase and aromatic l-amino acid decarboxylase molecular networks: Biomedical implications.
Sanchez-Jiménez F, Pino-Ángeles A, Rodríguez-López R, Morales M, Urdiales JL. | 12/30/2017 |
| a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population | Investigation of a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population: A Family-Based Study.
Dong H, Liu W, Liu M, Xu L, Li Q, Zhang R, Zhang X, Liu S., Free PMC Article | 08/5/2017 |
| Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Co-expression of VMAT-2 and HDC might be required for increased histamine production in patients with gastric neuroendocrine tumors. | Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours.
Tsolakis AV, Grimelius L, Granerus G, Stridsberg M, Falkmer SE, Janson ET., Free PMC Article | 01/14/2017 |
| The findings indicate that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer. | Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer.
He GH, Lin JJ, Cai WK, Xu WM, Yu ZP, Yin SJ, Zhao CH, Xu GL., Free PMC Article | 09/5/2015 |
| HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure | Relation of polymorphism of the histidine decarboxylase gene to chronic heart failure in Han Chinese.
He GH, Cai WK, Meng JR, Ma X, Zhang F, Lu J, Xu GL. | 08/1/2015 |
| Investigated variation across the HDC (histidine decarboxylase) gene for association with Tourette Syndrome. | Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families.
Karagiannidis I, Dehning S, Sandor P, Tarnok Z, Rizzo R, Wolanczyk T, Madruga-Garrido M, Hebebrand J, Nöthen MM, Lehmkuhl G, Farkas L, Nagy P, Szymanska U, Anastasiou Z, Stathias V, Androutsos C, Tsironi V, Koumoula A, Barta C, Zill P, Mir P, Müller N, Barr C, Paschou P. | 07/19/2014 |
| HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR, SHP, and CDX1. | Bile acid increases expression of the histamine-producing enzyme, histidine decarboxylase, in gastric cells.
Ku HJ, Kim HY, Kim HH, Park HJ, Cheong JH., Free PMC Article | 07/19/2014 |
| Data indicate that histidine decarboxylase (HDC) is expressed by neutrophils. | Histamine production by human neutrophils.
Alcañiz L, Vega A, Chacón P, El Bekay R, Ventura I, Aroca R, Blanca M, Bergstralh DT, Monteseirin J. | 09/21/2013 |
| Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. | Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase.
Komori H, Nitta Y, Ueno H, Higuchi Y., Free PMC Article | 11/3/2012 |
| crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees | Purification, crystallization and preliminary X-ray analysis of human histidine decarboxylase.
Komori H, Nitta Y, Ueno H, Higuchi Y., Free PMC Article | 09/15/2012 |
| It was shown that for serum and urine, HDC levels achieved sensitivities and specificities compatible to or even greater than those of established biomarkers for the diagnosis of intestinal mucosal injury in patients with acute intestinal obstruction. | Histidine decarboxylase is identified as a potential biomarker of intestinal mucosal injury in patients with acute intestinal obstruction.
Yang JJ, Ma YL, Zhang P, Chen HQ, Liu ZH, Qin HL., Free PMC Article | 08/4/2012 |
| The novel concept that an autocrine loop, consisting of enhanced histamine synthesis by histidine decarboxylase, sustains cholangiocarcinoma growth is proposed. | Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.
Francis H, DeMorrow S, Venter J, Onori P, White M, Gaudio E, Francis T, Greene JF Jr, Tran S, Meininger CJ, Alpini G., Free PMC Article | 07/28/2012 |
| Variants in the HDC gene may play little or no role in Tourette Syndrome susceptibility in Chinese Han population. | Mutation screening of the HDC gene in Chinese Han patients with Tourette syndrome.
Lei J, Deng X, Zhang J, Su L, Xu H, Liang H, Huang X, Song Z, Deng H. | 04/21/2012 |
| Studies provide lead compounds for inhibitors of ornithine decarboxylase and human histidine decarboxylase. | A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase.
Wu F, Christen P, Gehring H. | 10/1/2011 |
| The histidine decarboxylase allele Glu644 in homozygosity increases the risk of developing rhinitis in the studied population | Variability of the L-Histidine decarboxylase gene in allergic rhinitis.
Gervasini G, Agúndez JA, García-Menaya J, Martínez C, Cordobés C, Ayuso P, Cornejo JA, Blanca M, García-Martín E. | 03/5/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis which points to its role in Tourette's syndrome and tics | L-histidine decarboxylase and Tourette's syndrome.
Ercan-Sencicek AG, Stillman AA, Ghosh AK, Bilguvar K, O'Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Morgan TM, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T, Lifton RP, Gunel M, State MW., Free PMC Article | 05/31/2010 |
| HFR was regulated by HIF-1 activation. Depletion of HIF-1alpha prevents hypoxic induction of HDC in BMMCs. Hypoxia induces HDC expression by transcriptional mechanisms dependent upon HIF-1. | Activation of hypoxia-inducible factor-1 regulates human histidine decarboxylase expression.
Jeong HJ, Moon PD, Kim SJ, Seo JU, Kang TH, Kim JJ, Kang IC, Um JY, Kim HM, Hong SH., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R. | 03/25/2009 |
| Histamine decarboxylase expressed in endothelial cells of microvessels might play a role in regulating angiogenesis in esophageal squamous cell carcinomas. | Expression of non-mast cell histidine decarboxylase in tumor-associated microvessels in human esophageal squamous cell carcinomas.
Li Z, Liu J, Tang F, Liu Y, Waldum HL, Cui G. | 01/21/2010 |
| Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB., Free PMC Article | 02/11/2009 |