| HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6. | HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6.
Jiang S, Han X, Liu T, He Y, Zhao Z, Liu T, Cheng S, Zhang J, Duan L, Liu Y, Cheng T, Liu Y, Ye Q, Gao S. | 01/16/2024 |
| HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1. | HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1.
Han X, Jiang S, Gu Y, Ding L, Zhao E, Cao D, Wang X, Wen Y, Pan Y, Yan X, Duan L, Sun M, Zhou T, Liu Y, Hu H, Ye Q, Gao S., Free PMC Article | 05/19/2023 |
| HUNK phosphorylates EGFR to regulate breast cancer metastasis. | HUNK phosphorylates EGFR to regulate breast cancer metastasis.
Williams CB, Phelps-Polirer K, Dingle IP, Williams CJ, Rhett MJ, Eblen ST, Armeson K, Hill EG, Yeh ES., Free PMC Article | 11/28/2020 |
| Rubicon as a novel substrate of HUNK. | HUNK Phosphorylates Rubicon to Support Autophagy.
Zambrano JN, Eblen ST, Abt M, Rhett JM, Muise-Helmericks R, Yeh ES., Free PMC Article | 04/11/2020 |
| Recent work demonstrates a role for Hunk in HER2(+)/ErbB2(+) breast cancer progression, including drug resistance to HER2/ErbB2 inhibitors, with Hunk potentially acting downstream of HER2/ErbB2 and the PI3K/Akt pathway. [review] | Hormonally up-regulated neu-associated kinase: A novel target for breast cancer progression.
Zambrano JN, Neely BA, Yeh ES., Free PMC Article | 05/27/2017 |
| Our findings indicate that therapeutically targeting HUNK is a potential strategy for overcoming resistance and that resistant breast cancer cells maintain HUNK expression to drive tumorigenesis | Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors.
Yeh ES, Abt MA, Hill EG., Free PMC Article | 10/3/2015 |
| Hunk is required for HER2/neu-induced mammary tumorigenesis | Hunk is required for HER2/neu-induced mammary tumorigenesis.
Yeh ES, Yang TW, Jung JJ, Gardner HP, Cardiff RD, Chodosh LA., Free PMC Article | 04/30/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Data show that HUNK reconstitution in basal breast cancer cell lines prevented protein phosphatase 2-A (PP2A from binding to CFL-1. | HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.
Quintela-Fandino M, Arpaia E, Brenner D, Goh T, Yeung FA, Blaser H, Alexandrova R, Lind EF, Tusche MW, Wakeham A, Ohashi PS, Mak TW., Free PMC Article | 05/10/2010 |
| a gene expression signature that distinguishes Hunk-wild type from Hunk-deficient tumors predicts clinical outcome in women with breast cancer | The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.
Wertheim GB, Yang TW, Pan TC, Ramne A, Liu Z, Gardner HP, Dugan KD, Kristel P, Kreike B, van de Vijver MJ, Cardiff RD, Reynolds C, Chodosh LA., Free PMC Article | 01/21/2010 |
| Overproduction of MAK-V/Hunk in human breast cancer may be used fore more precise molecular typing. | [Proteinkinase MAK-V/Hunk as a possible dianostic and prognostic marker of human breast carcinoma].
Korobko IV, Zavalishina LE, Kiselev SL, Raĭkhlin NT, Frank GA. | 01/21/2010 |