| The tumor suppressor function of LSAMP is most likely exerted by reducing the proliferation rate of the tumor cells, possibly by indirectly upregulating one or more of the genes HES1, CTAG2 or KLF10. | Reexpression of LSAMP inhibits tumor growth in a preclinical osteosarcoma model.
Barøy T, Kresse SH, Skårn M, Stabell M, Castro R, Lauvrak S, Llombart-Bosch A, Myklebost O, Meza-Zepeda LA., Free PMC Article | 01/17/2015 |
| NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine | NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine.
Pollack SM, Li Y, Blaisdell MJ, Farrar EA, Chou J, Hoch BL, Loggers ET, Rodler E, Eary JF, Conrad EU 3rd, Jones RL, Yee C., Free PMC Article | 09/1/2012 |
| LAGE-1a and NY-ESO-1 homology cannot be easily exploited in an anti-NY-ESO-1 vaccine given the low frequency of protein expression detected by IHC or serum analysis. | Evaluation of LAGE-1 and NY-ESO-1 expression in multiple myeloma patients to explore possible benefits of their homology for immunotherapy.
de Carvalho F, Vettore AL, Inaoka RJ, Karia B, Andrade VC, Gnjatic S, Jungbluth AA, Colleoni GW., Free PMC Article | 04/30/2011 |
| Spontaneous LAGE-1-specific CD4-positive T cells isolated from patients with advanced LAGE-1-positive/NY-ESO-1-positive melanoma are directed against three promiscuous and immunodominant epitopes. | Epitope hierarchy of spontaneous CD4+ T cell responses to LAGE-1.
Kudela P, Sun Z, Fourcade J, Janjic B, Kirkwood JM, Maillere B, Zarour HM., Free PMC Article | 01/29/2011 |
| We evaluated the correlations among the expression levels of NY-ESO-1, LAGE-1 and SSX-1 and clinical parameters in hepatocellular carcinoma patients | Comparisons for detecting NY-ESO-1 mRNA expression levels in hepatocellular carcinoma tissues.
Wang XY, Chen HS, Luo S, Zhang HH, Fei R, Cai J. | 01/21/2010 |
| There is a high frequency of the LAGE-1 gene allele with SNPs in coding regions in cancer patients. | Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients.
Shao Y, Sun ZY, Sun SW, Zhao Y, Sin WY, Yuan YH, Simpson AJ, Old LJ, Sang XT, Mao YL, Xie Y, Huang JF, Zhao HT, Shao Y, Sun ZY, Sun SW, Zhao Y, Sin WY, Yuan YH, Simpson AJ, Old LJ, Sang XT, Mao YL, Xie Y, Huang JF, Zhao HT. | 01/21/2010 |
| MAGEC1/CT7, MAGEA3/6 and LAGE-1 are good candidates for immunotherapy, since together they cover 85% of the multiple myeloma cases. | Prognostic impact of cancer/testis antigen expression in advanced stage multiple myeloma patients.
Andrade VC, Vettore AL, Felix RS, Almeida MS, Carvalho F, Oliveira JS, Chauffaille ML, Andriolo A, Caballero OL, Zago MA, Colleoni GW., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Identification and expression analysis of novel LAGE-1 alleles with single nucleotide polymorphisms in cancer patients.
Shao Y, Sun ZY, Sun SW, Zhao Y, Sin WY, Yuan YH, Simpson AJ, Old LJ, Sang XT, Mao YL, Xie Y, Huang JF, Zhao HT, Shao Y, Sun ZY, Sun SW, Zhao Y, Sin WY, Yuan YH, Simpson AJ, Old LJ, Sang XT, Mao YL, Xie Y, Huang JF, Zhao HT. | 03/13/2008 |
| Data support the immunogenicity of NY-ESO-1/LAGE-1 ORF2 gene products and clearly demonstrate their capability to stimulate T-helper 1 type CD4+ T cells. | The alternative open reading frame of LAGE-1 gives rise to multiple promiscuous HLA-DR-restricted epitopes recognized by T-helper 1-type tumor-reactive CD4+ T cells.
Mandic M, Almunia C, Vicel S, Gillet D, Janjic B, Coval K, Maillere B, Kirkwood JM, Zarour HM. | 01/21/2010 |
| Data showed aberrant expression of NY-ESO-1 and LAGE-1 by IHC/RT-PCR in a significant proportion of epithelial ovarian cancer patients. | NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer.
Odunsi K, Jungbluth AA, Stockert E, Qian F, Gnjatic S, Tammela J, Intengan M, Beck A, Keitz B, Santiago D, Williamson B, Scanlan MJ, Ritter G, Chen YT, Driscoll D, Sood A, Lele S, Old LJ. | 01/21/2010 |
| first peptide epitope recognized by sera from a wide spectrum of cancer patients but not healthy donors | Dominant B cell epitope from NY-ESO-1 recognized by sera from a wide spectrum of cancer patients: implications as a potential biomarker.
Zeng G, Aldridge ME, Wang Y, Pantuck AJ, Wang AY, Liu YX, Han Y, Yuan YH, Robbins PF, Dubinett SM, deKernion JB, Belldegrun AS. | 01/21/2010 |
| Isolation of CD4+ T cell clones from T cell cultures of two healthy donors leads to identification of four naturally processed HLA-DR-binding CAMEL epitopes, interesting peptides to investigate for future cancer immunotherapy. | Identification of multiple HLA-DR-restricted epitopes of the tumor-associated antigen CAMEL by CD4+ Th1/Th2 lymphocytes.
Slager EH, van der Minne CE, Krüse M, Krueger DD, Griffioen M, Osanto S. | 01/21/2010 |
| CD4+ T cell clones specific for alternatively translated tumor antigen CAMEL have been isolated from the peripheral blood of a melanoma patient; CAMEL(81-102) is described as a naturally processed epitope recognized and presented by HLA-DR11 and HLA-DR12. | CD4+ Th2 cell recognition of HLA-DR-restricted epitopes derived from CAMEL: a tumor antigen translated in an alternative open reading frame.
Slager EH, Borghi M, van der Minne CE, Aarnoudse CA, Havenga MJ, Schrier PI, Osanto S, Griffioen M. | 01/21/2010 |
| LAGE-1 expression was detected in esophageal cancer by cDNA RDA. LAGE-1 might have the potential to be a target antigen for anti-tumoral immunotherapy in esophageal cancers because of its tumor-specific expression similar to that of MAGE-A1. | A new specific gene expression in squamous cell carcinoma of the esophagus detected using representational difference analysis and cDNA microarray.
Kan T, Yamasaki S, Kondo K, Teratani N, Kawabe A, Kaganoi J, Meltzer SJ, Imamura M, Shimada Y. | 01/21/2010 |
| LAGE-1 expression was more frequently found in squamous cell carcinoma than in adenocarcinoma. | [Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery].
Wang Y, Liang Z, Yuan YH, Han Y, Liu YX, Liu N, Chen YT, Ritter G, Old LJ, Zhang LJ. | 01/21/2010 |