| SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma. | SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma.
Yang Y, Huang L, Zhang N, Deng YN, Cao X, Liang Y, Hou H, Luo Y, Yang Y, Li Q, Liang S., Free PMC Article | 04/5/2024 |
| Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity. | Annexin A6 mitigates neurological deficit in ischemia/reperfusion injury by promoting synaptic plasticity.
Wang Y, Yang Z, Wang R, Zheng Y, Han Z, Fan J, Yan F, Liu P, Luo Y., Free PMC Article | 02/23/2024 |
| Comprehensive analysis the diagnosis, malignant progression and immune infiltrate of ANXA6 in prostate cancer. | Comprehensive analysis the diagnosis, malignant progression and immune infiltrate of ANXA6 in prostate cancer.
Huang B, Yang K. | 08/22/2023 |
| Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair. | Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repair.
Williams JK, Ngo JM, Lehman IM, Schekman R., Free PMC Article | 06/15/2023 |
| Annexin-A5 and annexin-A6 silencing prevents metastasis of breast cancer cells in zebrafish. | Annexin-A5 and annexin-A6 silencing prevents metastasis of breast cancer cells in zebrafish.
Gounou C, Bouvet F, Liet B, Prouzet-Mauléon V, d'Agata L, Harté E, Argoul F, Siegfried G, Iggo R, Khatib AM, Bouter A. | 06/9/2023 |
| Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions. | Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions.
Jose J, Hoque M, Engel J, Beevi SS, Wahba M, Georgieva MI, Murphy KJ, Hughes WE, Cochran BJ, Lu A, Tebar F, Hoy AJ, Timpson P, Rye KA, Enrich C, Rentero C, Grewal T., Free PMC Article | 03/5/2022 |
| The Impact of ANxA6 Gene Polymorphism on the Efficacy of Methotrexate Treatment in Psoriasis Patients. | The Impact of ANxA6 Gene Polymorphism on the Efficacy of Methotrexate Treatment in Psoriasis Patients.
Fan Z, Zhang Z, Huang Q, Han L, Fang X, Yang K, Wu S, Zheng Z, Yawalkar N, Wang Z, Yan K. | 12/18/2021 |
| CRISPR-Cas9 mediated knockout of AnxA6 gene enhances influenza A virus replication in low-permissive HEK293FT cell line. | CRISPR-Cas9 mediated knockout of AnxA6 gene enhances influenza A virus replication in low-permissive HEK293FT cell line.
Komissarov A, Sergeeva M, Zhuravlev E, Medvedev S, Malakhova A, Andreeva E, Shurygina AP, Gorshkov A, Timofeeva M, Balakhonova E, Grudinin M, Zakian S, Richter V, Stepanov G. | 12/11/2021 |
| Annexins A2, A6 and Fetuin-A Affect the Process of Mineralization in Vesicles Derived from Human Osteoblastic hFOB 1.19 and Osteosarcoma Saos-2 Cells. | Annexins A2, A6 and Fetuin-A Affect the Process of Mineralization in Vesicles Derived from Human Osteoblastic hFOB 1.19 and Osteosarcoma Saos-2 Cells.
Bozycki L, Mroczek J, Bessueille L, Mebarek S, Buchet R, Pikula S, Strzelecka-Kiliszek A., Free PMC Article | 05/15/2021 |
| Diverse Roles of Annexin A6 in Triple-Negative Breast Cancer Diagnosis, Prognosis and EGFR-Targeted Therapies. | Diverse Roles of Annexin A6 in Triple-Negative Breast Cancer Diagnosis, Prognosis and EGFR-Targeted Therapies.
Korolkova OY, Widatalla SE, Williams SD, Whalen DS, Beasley HK, Ochieng J, Grewal T, Sakwe AM., Free PMC Article | 03/28/2021 |
| Annexin-A6 in Membrane Repair of Human Skeletal Muscle Cell: A Role in the Cap Subdomain. | Annexin-A6 in Membrane Repair of Human Skeletal Muscle Cell: A Role in the Cap Subdomain.
Croissant C, Gounou C, Bouvet F, Tan S, Bouter A., Free PMC Article | 03/6/2021 |
| Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells. | Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells.
Meneses-Salas E, García-Melero A, Blanco-Muñoz P, Jose J, Brenner MS, Lu A, Tebar F, Grewal T, Rentero C, Enrich C., Free PMC Article | 02/27/2021 |
| Upregulated Expression of Calcium-Dependent Annexin A6: A Potential Biomarker of Ovarian Carcinoma. | Upregulated Expression of Calcium-Dependent Annexin A6: A Potential Biomarker of Ovarian Carcinoma.
Noreen S, Gardner QA, Fatima I, Sadaf S, Akhtar MW. | 02/6/2021 |
| Localization of Annexin A6 in Matrix Vesicles During Physiological Mineralization. | Localization of Annexin A6 in Matrix Vesicles During Physiological Mineralization.
Veschi EA, Bolean M, Strzelecka-Kiliszek A, Bandorowicz-Pikula J, Pikula S, Granjon T, Mebarek S, Magne D, Ramos AP, Rosato N, Millán JL, Buchet R, Bottini M, Ciancaglini P., Free PMC Article | 12/5/2020 |
| AnxA6 may be a reliable biomarker for distant relapse-free survival and response of triple negative breast cancer (TNBC) patients to chemotherapy, and that the reciprocal expression of AnxA6 and GRF2 can reliably delineate TNBCs into rapidly growing and invasive subsets which may be more relevant for subset-specific therapeutic interventions. | Reciprocal expression of Annexin A6 and RasGRF2 discriminates rapidly growing from invasive triple negative breast cancer subsets.
Korolkova OY, Widatalla SE, Whalen DS, Nangami GN, Abimbola A, Williams SD, Beasley HK, Reisenbichler E, Washington MK, Ochieng J, Mayer IA, Lehmann BD, Sakwe AM., Free PMC Article | 08/12/2020 |
| Here, we demonstrate that this cellular cholesterol imbalance is due to AnxA6 promoting Rab7 inactivation via TBC1D15, a Rab7-GAP. | Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells.
Meneses-Salas E, García-Melero A, Kanerva K, Blanco-Muñoz P, Morales-Paytuvi F, Bonjoch J, Casas J, Egert A, Beevi SS, Jose J, Llorente-Cortés V, Rye KA, Heeren J, Lu A, Pol A, Tebar F, Ikonen E, Grewal T, Enrich C, Rentero C., Free PMC Article | 07/11/2020 |
| These data suggest that lapatinib-induced AnxA6 expression and accumulation of cholesterol in late endosomes constitute an adaptive mechanism for EGFR-expressing triple-negative breast cancer (TNBC) cells to overcome prolong treatment with EGFR-targeted TKIs and can be exploited as an option to inhibit and/or monitor the frequently observed acquired resistance to these drugs. | Lapatinib-induced annexin A6 upregulation as an adaptive response of triple-negative breast cancer cells to EGFR tyrosine kinase inhibitors.
Widatalla SE, Korolkova OY, Whalen DS, Goodwin JS, Williams KP, Ochieng J, Sakwe AM., Free PMC Article | 05/9/2020 |
| Annexin A4 binds to artificial membranes and generates curvature force initiated from free edges, whereas annexin A6 induces constriction force. | Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair.
Boye TL, Maeda K, Pezeshkian W, Sønder SL, Haeger SC, Gerke V, Simonsen AC, Nylandsted J., Free PMC Article | 09/15/2018 |
| This review will discuss how the multiple scaffold functions may enable AnxA6 to modulate migratory cell behavior in health and disease | Annexin A6-A multifunctional scaffold in cell motility.
Grewal T, Hoque M, Conway JRW, Reverter M, Wahba M, Beevi SS, Timpson P, Enrich C, Rentero C., Free PMC Article | 03/17/2018 |
| Immunoprecipitation of the products obtained from the transcription/translation system using various anti-annexin A6 antibodies confirmed the presence of several isoforms and suggested that this protein might be present in different configurations. | Two translation initiation codons direct the expression of annexin VI 64kDa and 68kDa isoforms.
González-Noriega A, Michalak C, Cervantes-Roldán R, Gómez-Romero V, León-Del-Río A. | 12/16/2017 |
| AnxA6 protein in adipocytes was upregulated by oxidative stress which might trigger AnxA6 induction in adipose tissues and contribute to impaired fat storage and adiponectin release. | Annexin A6 regulates adipocyte lipid storage and adiponectin release.
Krautbauer S, Haberl EM, Eisinger K, Pohl R, Rein-Fischboeck L, Rentero C, Alvarez-Guaita A, Enrich C, Grewal T, Buechler C, Neumeier M. | 11/18/2017 |
| High ANXA6 expression is associated with neoplasms. | A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer.
O'Sullivan D, Dowling P, Joyce H, McAuley E, McCann A, Henry M, McGovern B, Barham P, Kelleher FC, Murphy J, Kennedy S, Swan N, Moriarty M, Clynes M, Larkin A., Free PMC Article | 11/11/2017 |
| stable or transient AnxA6 overexpression in HuH7 cells led to elevated lipid droplet numbers/size and neutral lipid staining under control conditions | Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation.
Cairns R, Alvarez-Guaita A, Martínez-Saludes I, Wason SJ, Hanh J, Nagarajan SR, Hosseini-Beheshti E, Monastyrskaya K, Hoy AJ, Buechler C, Enrich C, Rentero C, Grewal T. | 10/21/2017 |
| Annexin VI is enriched in calcifying valve interstitial cell derived-matrix vesicles from patients with end stage renal disease-induced hypercalcemia and aortic valve calcification. | End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.
Cui L, Rashdan NA, Zhu D, Milne EM, Ajuh P, Milne G, Helfrich MH, Lim K, Prasad S, Lerman DA, Vesey AT, Dweck MR, Jenkins WS, Newby DE, Farquharson C, Macrae VE., Free PMC Article | 09/23/2017 |
| These findings suggest that cancer-associated fibroblasts -tumor cell crosstalk supported by ANXA6+ EVs is predictive of pancreatic ductal adenocarcinoma aggressiveness, highlighting a therapeutic target and potential biomarker for pancreatic ductal adenocarcinoma. | Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.
Leca J, Martinez S, Lac S, Nigri J, Secq V, Rubis M, Bressy C, Sergé A, Lavaut MN, Dusetti N, Loncle C, Roques J, Pietrasz D, Bousquet C, Garcia S, Granjeaud S, Ouaissi M, Bachet JB, Brun C, Iovanna JL, Zimmermann P, Vasseur S, Tomasini R., Free PMC Article | 09/2/2017 |