| HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function. | HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic mechanisms to regulate human regulatory T cell differentiation and function.
Andrabi SBA, Batkulwar K, Bhosale SD, Moulder R, Khan MH, Buchacher T, Khan MM, Arnkil I, Rasool O, Marson A, Kalim UU, Lahesmaa R. | 11/15/2023 |
| The promoter methylation drives down-regulation mode of HIC1 in gastric cancer, its molecular characteristics and downstream functional pathways. | The promoter methylation drives down-regulation mode of HIC1 in gastric cancer, its molecular characteristics and downstream functional pathways.
Zhao T, Yang T, Zhang J, Hao H, Wang D, Afirifa J, Cai M, Cui X, Bai J, Fu S, Yu J. | 04/23/2022 |
| Dysregulated HIC1 and RassF1A expression in vitro alters the cell cytoskeleton and exosomal Piwi-interacting RNA. | Dysregulated HIC1 and RassF1A expression in vitro alters the cell cytoskeleton and exosomal Piwi-interacting RNA.
Sun CY, Chen GD, He BC, Fu WE, Lee CH, Leu YW, Hsiao SH. | 03/19/2022 |
| FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer. | FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer.
Yao J, Yang J, Yang Z, Wang XP, Yang T, Ji B, Zhang ZY., Free PMC Article | 02/5/2022 |
| DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk. | DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk.
Śnit M, Misiołek M, Ścierski W, Koniewska A, Stryjewska-Makuch G, Okła S, Grzeszczak W., Free PMC Article | 08/14/2021 |
| Phosphorylation of HIC1 (Hypermethylated in Cancer 1) Ser694 by ATM is essential for DNA repair. | Phosphorylation of HIC1 (Hypermethylated in Cancer 1) Ser694 by ATM is essential for DNA repair.
Paget S, Dubuissez M, Page A, Dehennaut V, Loison I, Spruyt N, Leprince D. | 07/10/2021 |
| Detection of aberrant methylation of HOXA9 and HIC1 through multiplex MethyLight assay in serum DNA for the early detection of epithelial ovarian cancer. | Detection of aberrant methylation of HOXA9 and HIC1 through multiplex MethyLight assay in serum DNA for the early detection of epithelial ovarian cancer.
Singh A, Gupta S, Badarukhiya JA, Sachan M. | 04/17/2021 |
| Low HIC1 expression is associated with bladder cancer progression. | Hypermethylated in cancer 1 (HIC1) suppresses bladder cancer progression by targeting yes-associated protein (YAP) pathway.
Zhou X, Zhang P, Han H, Lei H, Zhang X. | 07/11/2020 |
| IL-6 present in the tumor microenvironment downregulates the tumor suppressor HIC1 in breast cancer cells. | Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer.
Sun X, Qu Q, Lao Y, Zhang M, Yin X, Zhu H, Wang Y, Yang J, Yi J, Hao M., Free PMC Article | 05/23/2020 |
| HIC1 expression was downregulated in lung tumor tissues. Loss of HIC1 expression increased proliferation and migration. DNA repair pathway was associated with loss of HIC1. | Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression.
Li Y, Yao M, Wu T, Zhang L, Wang Y, Chen L, Fu G, Weng X, Wang J. | 02/29/2020 |
| the chemokine (C-X-C motif) ligand 14 (CXCL14) secreted by HIC1-deleted Breast cancer cells bound to its cognate receptor GPR85 on mammary fibroblasts in the microenvironment and was responsible for activating these fibroblasts via the ERK1/2, Akt, and neddylation pathways. | HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk.
Wang Y, Weng X, Wang L, Hao M, Li Y, Hou L, Liang Y, Wu T, Yao M, Lin G, Jiang Y, Fu G, Hou Z, Meng X, Lu J, Wang J., Free PMC Article | 09/21/2019 |
| HIC1 is an important contributor to Induced Regulatory T Cells cell development and function. | Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells.
Ubaid Ullah, Andrabi SBA, Tripathi SK, Dirasantha O, Kanduri K, Rautio S, Gross CC, Lehtimäki S, Bala K, Tuomisto J, Bhatia U, Chakroborty D, Elo LL, Lähdesmäki H, Wiendl H, Rasool O, Lahesmaa R., Free PMC Article | 06/1/2019 |
| Loss of Hic1 expression in the early stages of tumor formation may contribute to malignant transformation through the acquisition of chromosomal instability. | The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.
Szczepny A, Carey K, McKenzie L, Jayasekara WSN, Rossello F, Gonzalez-Rajal A, McCaw AS, Popovski D, Wang D, Sadler AJ, Mahar A, Russell PA, Wright G, McCloy RA, Garama DJ, Gough DJ, Baylin SB, Burgess A, Cain JE, Watkins DN., Free PMC Article | 03/9/2019 |
| In this present work, the authors identify and characterize a transcription factor i.e. HIC1, which physically interacts with both Bcl11b/CTIP2 and HMGA1 to co-regulate specific subsets of cellular genes and the HIV-1 tat gene. | HIC1 controls cellular- and HIV-1- gene transcription via interactions with CTIP2 and HMGA1.
Le Douce V, Forouzanfar F, Eilebrecht S, Van Driessche B, Ait-Ammar A, Verdikt R, Kurashige Y, Marban C, Gautier V, Candolfi E, Benecke AG, Van Lint C, Rohr O, Schwartz C., Free PMC Article | 06/23/2018 |
| our data demonstrate that HIC1 SUMOylation is important for the transcriptional response to non-repairable DSBs but dispensable for DNA repair. | HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).
Paget S, Dubuissez M, Dehennaut V, Nassour J, Harmon BT, Spruyt N, Loison I, Abbadie C, Rood BR, Leprince D., Free PMC Article | 03/10/2018 |
| Data suggest that aberrant expression of hypermethylated in cancer-1 (HIC1)/sirtuin-1 (SIRT1) and hypermethylation of the HIC1 promoter may be critical for the development and progression of papillary thyroid cancer. | Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma.
Wu W, Zhang L, Lin J, Huang H, Shi B, Lin X, Huang Z, Wang C, Qiu J, Wei X., Free PMC Article | 03/10/2018 |
| Hypermethylation of HIC1 gene is associated with Colon Cancer. | Methylation of the Tumor Suppressor Genes HIC1 and RassF1A Clusters Independently From the Methylation of Polycomb Target Genes in Colon Cancer.
Chen HC, Huang HY, Chen YL, Lee KD, Chu YR, Lin PY, Hsu CC, Chu PY, Huang TH, Hsiao SH, Leu YW. | 03/10/2018 |
| Data show that secretion of IL-6 induced by loss of HIC1 activated STAT3 through IL-6/JAK pathway and was associated with NSCLC progression. | Hypermethylated in cancer 1(HIC1) suppresses non-small cell lung cancer progression by targeting interleukin-6/Stat3 pathway.
Wang X, Wang Y, Xiao G, Wang J, Zu L, Hao M, Sun X, Fu Y, Hu G, Wang J., Free PMC Article | 12/23/2017 |
| The VNTR sequence near HIC1 could be a predictive marker for oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. | Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.
Okazaki S, Schirripa M, Loupakis F, Cao S, Zhang W, Yang D, Ning Y, Berger MD, Miyamoto Y, Suenaga M, Iqubal S, Barzi A, Cremolini C, Falcone A, Battaglin F, Salvatore L, Borelli B, Helentjaris TG, Lenz HJ., Free PMC Article | 11/26/2017 |
| Therefore, our data identify HIC1 as a novel factor involved in B cell differentiation acting as an epigenetic repressor of CIITA transcription. | HIC1 epigenetically represses CIITA transcription in B lymphocytes.
Zeng S, Yang Y, Cheng X, Zhou B, Li P, Zhao Y, Kong X, Xu Y. | 11/4/2017 |
| HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition. | HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
Hao M, Li Y, Wang J, Qin J, Wang Y, Ding Y, Jiang M, Sun X, Zu L, Chang K, Lin G, Du J, Korinek V, Ye DW, Wang J. | 09/23/2017 |
| Data show that expression of hypermethylated in cancer 1 protein (HIC1) is downregulated in uveal melanoma. | HIC1 modulates uveal melanoma progression by activating lncRNA-numb.
Cheng G, He J, Zhang L, Ge S, Zhang H, Fan X. | 02/25/2017 |
| HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic ductal adenocarcinoma. | HIC1 attenuates invasion and metastasis by inhibiting the IL-6/STAT3 signalling pathway in human pancreatic cancer.
Hu B, Zhang K, Li S, Li H, Yan Z, Huang L, Wu J, Han X, Jiang W, Mulatibieke T, Zheng L, Wan R, Wang X, Hu G. | 02/18/2017 |
| Epigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma via EphA2 signaling. | Epigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma.
Li P, Liu X, Dong ZM, Ling ZQ., Free PMC Article | 09/10/2016 |
| The tumor-suppressive function of Hic1 in colon is related to its inhibitory action on proproliferative signaling mediated by the Tlr2 receptor present on tumor cells. | HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis.
Janeckova L, Pospichalova V, Fafilek B, Vojtechova M, Tureckova J, Dobes J, Dubuissez M, Leprince D, Baloghova N, Horazna M, Hlavata A, Stancikova J, Sloncova E, Galuskova K, Strnad H, Korinek V. | 04/2/2016 |