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    HLA-DOB major histocompatibility complex, class II, DO beta [ Homo sapiens (human) ]

    Gene ID: 3112, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil.

    MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil.
    Castelli EC, de Castro MV, Naslavsky MS, Scliar MO, Silva NSB, Pereira RN, Ciriaco VAO, Castro CFB, Mendes-Junior CT, Silveira ES, de Oliveira IM, Antonio EC, Vieira GF, Meyer D, Nunes K, Matos LRB, Silva MVR, Wang JYT, Esposito J, Cória VR, Magawa JY, Santos KS, Cunha-Neto E, Kalil J, Bortolin RH, Hirata MH, Dell'Aquila LP, Razuk-Filho A, Batista-Júnior PB, Duarte-Neto AN, Dolhnikoff M, Saldiva PHN, Passos-Bueno MR, Zatz M., Free PMC Article

    11/26/2022
    results indicate that HLA-DOB is co-inherited with DQA2-B2 genes and thus may contribute to HCV and HBV persistence

    Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.
    Denzin LK, Khan AA, Virdis F, Wilks J, Kane M, Beilinson HA, Dikiy S, Case LK, Roopenian D, Witkowski M, Chervonsky AV, Golovkina TV., Free PMC Article

    09/30/2017
    TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population

    Association of polymorphisms in HLA antigen presentation-related genes with the outcomes of HCV infection.
    Huang P, Zhang Y, Lu X, Xu Y, Wang J, Zhang Y, Yu R, Su J., Free PMC Article

    01/30/2016
    HLA-DO beta-chain antigens are ubiquitinated by MARCH family E3 ligases 1, 8, and 9.

    Ubiquitination of HLA-DO by MARCH family E3 ligases.
    Jahnke M, Trowsdale J, Kelly AP., Free PMC Article

    06/22/2013
    results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation

    HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
    Guce AI, Mortimer SE, Yoon T, Painter CA, Jiang W, Mellins ED, Stern LJ., Free PMC Article

    03/2/2013
    Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article

    06/30/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA.

    01/20/2010
    Observational study of genetic testing. (HuGE Navigator)

    A flexible array format for large-scale, rapid blood group DNA typing.
    Hashmi G, Shariff T, Seul M, Vissavajjhala P, Hue-Roye K, Charles-Pierre D, Lomas-Francis C, Chaudhuri A, Reid ME.

    03/13/2008
    A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing.

    Identification of a novel HLA-DOB-allele, DOB*010103, by sequence-based typing in the Korean population.
    Gu H, Lee JK, Oh B.

    01/21/2010
    In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation.

    Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation.
    Fallas JL, Tobin HM, Lou O, Guo D, Sant'Angelo DB, Denzin LK.

    01/21/2010
    HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias.

    Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies.
    van Lith M, van Ham M, Neefjes J.

    01/21/2010
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