| HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort. | HMGN1 plays a significant role in CRLF2 driven Down Syndrome leukemia and provides a potential therapeutic target in this high-risk cohort.
Page EC, Heatley SL, Eadie LN, McClure BJ, de Bock CE, Omari S, Yeung DT, Hughes TP, Thomas PQ, White DL. | 07/28/2024 |
| Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain. | Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain.
Farley SJ, Grishok A, Zeldich E., Free PMC Article | 12/17/2022 |
| Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome. | Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome.
Rodríguez-Ortiz A, Montoya-Villegas JC, García-Vallejo F, Mina-Paz Y., Free PMC Article | 02/19/2022 |
| Transcriptional amplification downstream of HMGN1 is enriched for stage-specific programs of B cells and B cell acute lymphoblastic leukemia, dependent on the developmental cellular context. | Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression.
Mowery CT, Reyes JM, Cabal-Hierro L, Higby KJ, Karlin KL, Wang JH, Kimmerling RJ, Cejas P, Lim K, Li H, Furusawa T, Long HW, Pellman D, Chapuy B, Bustin M, Manalis SR, Westbrook TF, Lin CY, Lane AA., Free PMC Article | 12/14/2019 |
| Studies indicate that high mobility group nucleosome binding domain 1 (HMGN1) preferentially promotes Th1-type immunity, which makes it relevant for the fields of vaccinology, autoimmunity, and oncoimmunology [Review]. | High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin.
Yang D, Han Z, Alam MM, Oppenheim JJ. | 02/2/2019 |
| HMGN1 and HMGN 2 remodel core and linker histone tail domains within chromatin. | HMGN1 and 2 remodel core and linker histone tail domains within chromatin.
Murphy KJ, Cutter AR, Fang H, Postnikov YV, Bustin M, Hayes JJ., Free PMC Article | 10/21/2017 |
| RNA-seq evidence of biallelic expression of HMGN1 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of HMGN1 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. | Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.
Alves da Silva AF, Machado FB, Pavarino ÉC, Biselli-Périco JM, Zampieri BL, da Silva Francisco Junior R, Mozer Rodrigues PT, Terra Machado D, Santos-Rebouças CB, Gomes Fernandes M, Chuva de Sousa Lopes SM, Lopes Rios ÁF, Medina-Acosta E., Free PMC Article | 05/9/2016 |
| HMGN1 can serve as a useful clinical parameter for evaluating disease progression and predicting the outcomes for early-stage patients with non-small cell lung cancer . | High-mobility group nucleosome-binding protein 1 is a novel clinical biomarker in non-small cell lung cancer.
Wei F, Yang F, Jiang X, Yu W, Ren X. | 04/23/2016 |
| nucleosome binding protein HMGN1 as a new PCNA-interacting protein that enhances the binding of PCNA to chromatin | The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin.
Postnikov YV, Kurahashi T, Zhou M, Bustin M., Free PMC Article | 07/6/2013 |
| extracellular HMGN1 acts as a novel alarmin critical for LPS-induced development of innate and adaptive immune responses. | High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses.
Yang D, Postnikov YV, Li Y, Tewary P, de la Rosa G, Wei F, Klinman D, Gioannini T, Weiss JP, Furusawa T, Bustin M, Oppenheim JJ., Free PMC Article | 04/14/2012 |
| HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) in mouse and human, and affects the behavior of mice | The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice.
Abuhatzira L, Shamir A, Schones DE, Schäffer AA, Bustin M., Free PMC Article | 02/25/2012 |
| HMGN1 is not randomly distributed throughout the genome. Instead, the protein preferentially localizes to DNase I hypersensitive (HS) sites, promoters, functional enhancers, and transcription factor binding sites. | Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions.
Cuddapah S, Schones DE, Cui K, Roh TY, Barski A, Wei G, Rochman M, Bustin M, Zhao K., Free PMC Article | 03/5/2011 |
| HMGN1 (HMG14) and HMGN2 (HMG17) potently repress ATP-dependent chromatin remodeling by four different molecular motor proteins. | HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility.
Rattner BP, Yusufzai T, Kadonaga JT., Free PMC Article | 01/21/2010 |
| These studies demonstrate that the mode of binding of HMGNs to chromatin is cell cycle dependent. | Cell cycle-dependent binding of HMGN proteins to chromatin.
Cherukuri S, Hock R, Ueda T, Catez F, Rochman M, Bustin M., Free PMC Article | 01/21/2010 |
| These findings indicate that HMGN1 regulates the expression of particular genes via specific protein-protein interactions with transcription factors at target gene regulatory regions. | HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors.
Zhu N, Hansen U., Free PMC Article | 01/21/2010 |
| SWI/SNF functions independently of HMGN1 | Effects of HMGN1 on chromatin structure and SWI/SNF-mediated chromatin remodeling.
Hill DA, Peterson CL, Imbalzano AN. | 01/21/2010 |
| Five serine residues, i.e., Ser6, Ser7, Ser85, Ser88, and Ser98, in HMGN1 can be phosphorylated by the kinase in vitro, and Ser6, Ser7, and Ser85 were new sites among these five sites. | Phosphorylation of human high mobility group N1 protein by protein kinase CK2.
Jiang XG, Wang Y. | 01/21/2010 |
| Results show that four serine residues, i.e., Ser6, Ser85, Ser88, and Ser98, can be phosphorylated in high mobility group N1 (HMGN1). | Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells.
Zou Y, Jiang X, Wang Y. | 01/21/2010 |
| HMGN1 optimizes the cellular response to ionizing radiation and to other tumorigenic events; therefore, loss of this protein increases the tumor burden in mice. | Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1.
Birger Y, Catez F, Furusawa T, Lim JH, Prymakowska-Bosak M, West KL, Postnikov YV, Haines DC, Bustin M., Free PMC Article | 01/21/2010 |