| Age-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats. | Age-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats.
Fukuyama K, Motomura E, Okada M., Free PMC Article | 02/22/2024 |
| Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury-induced mechanical allodynia. | Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury-induced mechanical allodynia.
Kurisu R, Saigusa T, Aono Y, Hayashi Y, Hitomi S, Shimada M, Iwata K, Shinoda M. | 04/24/2023 |
| Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet. | Sex-specific effects of metformin and liraglutide on renal pathology and expression of connexin 45 and pannexin 1 following long-term high-fat high-sugar diet.
Luetić M, Kretzschmar G, Grobe M, Jerčić L, Bota I, Ivić V, Balog M, Zjalić M, Vitlov Uljević M, Heffer M, Gaspar R, Tabi T, Vukojević K, Vari SG, Filipović N. | 03/26/2022 |
| Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal Subnucleus Caudalis Is Involved in Tongue Cancer Pain. | Pannexin 1-Mediated ATP Signaling in the Trigeminal Spinal Subnucleus Caudalis Is Involved in Tongue Cancer Pain.
Koyama R, Iwata K, Hayashi Y, Hitomi S, Shibuta I, Furukawa A, Asano S, Kaneko T, Yonehara Y, Shinoda M., Free PMC Article | 01/15/2022 |
| A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII. | A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII.
López X, Palacios-Prado N, Güiza J, Escamilla R, Fernández P, Vega JL, Rojas M, Marquez-Miranda V, Chamorro E, Cárdenas AM, Maldifassi MC, Martínez AD, Duarte Y, González-Nilo FD, Sáez JC., Free PMC Article | 12/18/2021 |
| Role of Pannexin 1 ATP-Permeable Channels in the Regulation of Signaling Pathways during Skeletal Muscle Unloading. | Role of Pannexin 1 ATP-Permeable Channels in the Regulation of Signaling Pathways during Skeletal Muscle Unloading.
Zaripova KA, Kalashnikova EP, Belova SP, Kostrominova TY, Shenkman BS, Nemirovskaya TL., Free PMC Article | 10/30/2021 |
| Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus. | Mutational effects of Pannexin 1 R217H depend on the carboxyl-terminus.
Purohit R, Bera AK. | 09/11/2021 |
| Cystic fibrosis transmembrane conductance regulator-dependent bicarbonate entry controls rat cardiomyocyte ATP release via pannexin1 through mitochondrial signalling and caspase activation. | Cystic fibrosis transmembrane conductance regulator-dependent bicarbonate entry controls rat cardiomyocyte ATP release via pannexin1 through mitochondrial signalling and caspase activation.
Wang Y, Zhao J, Cai Y, Ballard HJ. | 07/31/2021 |
| Functional Coupling between the P2X7 Receptor and Pannexin-1 Channel in Rat Trigeminal Ganglion Neurons. | Functional Coupling between the P2X(7) Receptor and Pannexin-1 Channel in Rat Trigeminal Ganglion Neurons.
Inoue H, Kuroda H, Ofusa W, Oyama S, Kimura M, Ichinohe T, Shibukawa Y., Free PMC Article | 07/17/2021 |
| Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation. | Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation.
Lillo MA, Gaete PS, Puebla M, Burboa PC, Poblete I, Figueroa XF., Free PMC Article | 05/22/2021 |
| Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells. | Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells.
Tachikawa M, Murakami K, Akaogi R, Akanuma SI, Terasaki T, Hosoya KI. | 01/9/2021 |
| CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells. | CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells.
Gaete PS, Lillo MA, Puebla M, Poblete I, Figueroa XF., Free PMC Article | 10/24/2020 |
| Data indicate that the P2X7 receptor and pannexin-1 have important functions in pancreatic beta-cells (beta-cell) physiology, and should be considered in understanding and treatment of diabetes. | The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in β-cells.
Tozzi M, Larsen AT, Lange SC, Giannuzzo A, Andersen MN, Novak I., Free PMC Article | 10/26/2019 |
| Intracellular Ca(2+) chelation was previously shown to block receptor-mediated Panx-1 current activation in type II cells. | Evidence for protein kinase involvement in the 5-HT-[Ca(2+) ](i) -pannexin-1 signalling pathway in type II glial cells of the rat carotid body.
Leonard EM, Zhang M, Nurse CA. | 08/3/2019 |
| Panx1 is upregulated following myocardial I/R injury, leading to increased probenecid sensitive ATP release and P2Y2 receptor-dependent contraction is reduced in the coronary arteries. | Role of pannexin and adenosine triphosphate (ATP) following myocardial ischemia/reperfusion.
Kristiansen SB, Skovsted GF, Berchtold LA, Radziwon-Balicka A, Dreisig K, Edvinsson L, Sheykhzade M, Haanes KA. | 04/13/2019 |
| the upregulation of Pannexin1 expression may be involved in apoptosis and degeneration of neurons in the rat brain following ICH, and may contribute to subsequent cognitive dysfunction. | Pannexin-1 is involved in neuronal apoptosis and degeneration in experimental intracerebral hemorrhage in rats.
Zhou L, Liu C, Wang Z, Shen H, Wen Z, Chen D, Sun Q, Chen G., Free PMC Article | 09/1/2018 |
| identify and characterize a metabotropic NMDAR signaling complex comprised of NMDARs, Panx1 channels and Src kinase. | Metabotropic NMDA receptor signaling couples Src family kinases to pannexin-1 during excitotoxicity.
Weilinger NL, Lohman AW, Rakai BD, Ma EM, Bialecki J, Maslieieva V, Rilea T, Bandet MV, Ikuta NT, Scott L, Colicos MA, Teskey GC, Winship IR, Thompson RJ. | 07/16/2016 |
| panx1 contributes to distension- or LPS-evoked ATP release into the lumen of the bladder and that luminal release can modulate voiding function. | Pannexin 1 channels mediate the release of ATP into the lumen of the rat urinary bladder.
Beckel JM, Daugherty SL, Tyagi P, Wolf-Johnston AS, Birder LA, Mitchell CH, de Groat WC., Free PMC Article | 01/16/2016 |
| Px1 channels releasing ATP have any role in the constrictor actions of alpha1-adrenoceptor activation | Pannexin-1 channels do not regulate α1-adrenoceptor-mediated vasoconstriction in resistance arteries.
Angus JA, Betrie AH, Wright CE. | 11/28/2015 |
| These findings indicate that Panx1 participates in urothelial mechanotransduction and signaling by providing a direct pathway for mechanically-induced ATP release and by functionally interacting with P2X7Rs | Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling.
Negoro H, Urban-Maldonado M, Liou LS, Spray DC, Thi MM, Suadicani SO., Free PMC Article | 11/14/2015 |
| It was shown that angiotensin signaling in type II cells activates an inward current carried by Panx1 channels. | Angiotensin II mobilizes intracellular calcium and activates pannexin-1 channels in rat carotid body type II cells via AT1 receptors.
Murali S, Zhang M, Nurse CA., Free PMC Article | 10/17/2015 |
| ETV4 and cAMP response elements play a role in the transcriptional regulation of Panx1 in the epididymis. | Regulation of the pannexin-1 promoter in the rat epididymis.
Dufresne J, Cyr DG. | 08/29/2015 |
| Panx1 up-regulation contributes to pain hypersensitivity induced by nerve injury. | Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development.
Zhang Y, Laumet G, Chen SR, Hittelman WN, Pan HL., Free PMC Article | 08/29/2015 |
| These results show that P2X7 receptors and pannexin-1 channels are major mediators of postanoxic depolarization in neurons and of brain damage after ischemia | Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage.
Cisneros-Mejorado A, Gottlieb M, Cavaliere F, Magnus T, Koch-Nolte F, Scemes E, Pérez-Samartín A, Matute C., Free PMC Article | 06/20/2015 |
| Study found that astrocytes released ATP in response to mechanical strain, with pannexin 1 the predominant efflux pathway | Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain.
Beckel JM, Argall AJ, Lim JC, Xia J, Lu W, Coffey EE, Macarak EJ, Shahidullah M, Delamere NA, Zode GS, Sheffield VC, Shestopalov VI, Laties AM, Mitchell CH., Free PMC Article | 03/21/2015 |