| The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis. | The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis.
Lu Y, Dong CZ, Bao D, Zhong C, Liu K, Chen L, Wang W, Yang B. | 01/28/2023 |
| HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer. | HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer.
Kuo KT, Lin CH, Wang CH, Pikatan NW, Yadav VK, Fong IH, Yeh CT, Lee WH, Huang WC., Free PMC Article | 03/12/2022 |
| Inhibition of Astrocytic Histamine N-Methyltransferase as a Possible Target for the Treatment of Alzheimer's Disease. | Inhibition of Astrocytic Histamine N-Methyltransferase as a Possible Target for the Treatment of Alzheimer's Disease.
Flores-Clemente C, Nicolás-Vázquez MI, Mera Jiménez E, Hernández-Rodríguez M., Free PMC Article | 01/22/2022 |
| Histamine N-methyltransferase plays a central role in the degradation of the neurotransmitter histamine. Leucine 208 is a critical amino acid residue to maintain the structural integrity of the protein. Replacements by other amino acid residues have profound effects on stability and catalytic activity. | Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.
Tongsook C, Niederhauser J, Kronegger E, Straganz G, Macheroux P. | 12/22/2018 |
| NHMT polymorphisms are not associated with Parkinson's disease, ALS and multiple system atrophy in Chinese population. | Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms on the Incidence of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy in Chinese Populations.
Chen Y, Cao B, Ou R, Wei Q, Chen X, Zhao B, Wu Y, Song W, Shang HF. | 09/22/2018 |
| miR-223 participates in the pathogenesis of atopic dermatitis through upregulating HNMT indirectly to degrade the excessive histamine. | MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase.
Jia HZ, Liu SL, Zou YF, Chen XF, Yu L, Wan J, Zhang HY, Chen Q, Xiong Y, Yu B, Zhang W. | 09/1/2018 |
| The C allele for the HNMT polymorphism was associated with a lower degree of disability due to migraine (OR, 10.0; 95% CI, 2.65-37.6). In contrast, presence of the T allele (in heterozygous individuals) was associated with higher degree of disability (OR, 37.1; 95% CI, 4.37-315.2) | Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies.
Meza-Velázquez R, López-Márquez F, Espinosa-Padilla S, Rivera-Guillen M, Ávila-Hernández J, Rosales-González M. | 06/23/2018 |
| This study shown that eight linked SNPs (r(2) = 1) in the HNMT gene were associated with sedation according to the generalized linear model, adjusted for age, gender and BMI (false-discovery-rate-adjusted p = 0.013). | Histaminergic gene polymorphisms associated with sedation in clozapine-treated patients.
Solismaa A, Kampman O, Lyytikäinen LP, Seppälä N, Viikki M, Mononen N, Lehtimäki T, Leinonen E. | 03/10/2018 |
| Genotype and allelic variant frequencies of HNMT rs11558538 SNP 205 restless legs syndrome (RLS) patients and 410 controls using a TaqMan assay: HNMT rs11558538 genotypes allelic variants frequencies were similar between RLS patients and controls and not influenced by gender, family history of RLS, or RLS severity. Some evidence that RLS patients carrying the genotype rs11558538TT had an earlier age at onset. | Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome.
Jiménez-Jiménez FJ, García-Martín E, Alonso-Navarro H, Martínez C, Zurdo M, Turpín-Fenoll L, Millán-Pascual J, Adeva-Bartolomé T, Cubo E, Navacerrada F, Rojo-Sebastián A, Rubio L, Ortega-Cubero S, Pastor P, Calleja M, Plaza-Nieto JF, Pilo-de-la-Fuente B, Arroyo-Solera M, García-Albea E, Agúndez JA. | 02/24/2018 |
| The present meta-analysis confirms published evidence suggesting that the HNMT rs11558538 minor allele is related to a reduced risk of developing Parkinson disease | Thr105Ile (rs11558538) polymorphism in the histamine N-methyltransferase (HNMT) gene and risk for Parkinson disease: A PRISMA-compliant systematic review and meta-analysis.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Agúndez JAG., Free PMC Article | 02/25/2017 |
| this study shows that single nucleotide polymorphism is associated with the severity of allergic rhinitis in a group of Mexican children | Association between two polymorphisms of histamine-metabolising enzymes and the severity of allergic rhinitis in a group of Mexican children.
Meza-Velázquez R, López-Márquez F, Espinosa-Padilla S, Rivera-Guillen M, Gutíerrez-Díaz N, Pérez-Armendáriz L, Rosales-González M. | 02/4/2017 |
| The T allele of rs3787429 exhibited protective effect against CHF under the dominant and additive models , while, for SNPs in HRH2, DAO, and HNMT, no significant associations were observed in the present study | Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure.
He GH, Cai WK, Zhang JB, Ma CY, Yan F, Lu J, Xu GL., Free PMC Article | 12/17/2016 |
| HNMT is identified as a novel gene responsible for intellectual disability. The consequences of the identified missense mutations on the protein function are discussed. | Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.
Heidari A, Tongsook C, Najafipour R, Musante L, Vasli N, Garshasbi M, Hu H, Mittal K, McNaughton AJ, Sritharan K, Hudson M, Stehr H, Talebi S, Moradi M, Darvish H, Arshad Rafiq M, Mozhdehipanah H, Rashidinejad A, Samiei S, Ghadami M, Windpassinger C, Gillessen-Kaesbach G, Tzschach A, Ahmed I, Mikhailov A, Stavropoulos DJ, Carter MT, Keshavarz S, Ayub M, Najmabadi H, Liu X, Ropers HH, Macheroux P, Vincent JB., Free PMC Article | 07/16/2016 |
| HRH1-17 TT and HNMT-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP 4107 GG genotype was associated with nonallergic asthma among white children. | Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma.
Anvari S, Vyhlidal CA, Dai H, Jones BL., Free PMC Article | 04/9/2016 |
| results suggest that the heterozygous Thr/Ile genotype at the HNMT-Thr105Ile locus and the minor Ile105 allele protect against Parkinson's disease and schizophrenia in Han Chinese. | Association of histamine N-methyltransferase Thr105Ile polymorphism with Parkinson's disease and schizophrenia in Han Chinese: a case-control study.
Yang X, Liu C, Zhang J, Han H, Wang X, Liu Z, Xu Y., Free PMC Article | 03/19/2016 |
| The polymorphisms of HNMT and HRH3 were irrelevant with breast cancer in the present study. | Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer.
He GH, Lin JJ, Cai WK, Xu WM, Yu ZP, Yin SJ, Zhao CH, Xu GL., Free PMC Article | 09/5/2015 |
| The A939G HNMT polymorphism is associated with autoimmune MG, while no association with C314T SNP was found. | Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase.
Kellermayer B, Polgar N, Pal J, Banati M, Maasz A, Kisfali P, Hosszu Z, Juhasz A, Jensen HB, Tordai A, Rozsa C, Melegh B, Illes Z. | 07/19/2014 |
| The results of this study indicated that Histamine N-methyltransferase Thr105Ile polymorphism is associated Parkinson's disease. | Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease.
Palada V, Terzić J, Mazzulli J, Bwala G, Hagenah J, Peterlin B, Hung AY, Klein C, Krainc D. | 06/16/2012 |
| Lack of the association of HNMT Thr105Ile functional polymorphism with Alzheimer's disease is found. | No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.
Marasović-Šušnjara I, Palada V, Marinović-Terzić I, Mimica N, Marin J, Muck-Seler D, Mustapić M, Presečki P, Pivac N, Folnegović-Šmalc V, Marinović-Ćurin J, Terzić J. | 04/30/2011 |
| our results suggest that, despite the possible role of histamine in the inflammatory processes related with the pathogenesis of MS, HNMT polymorphism is not related with the risk for MS in Caucasian Spanish people | Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis.
García-Martín E, Martínez C, Benito-León J, Calleja P, Díaz-Sánchez M, Pisa D, Alonso-Navarro H, Ayuso-Peralta L, Torrecilla D, Agúndez JA, Jiménez-Jiménez FJ. | 08/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| This study do not support the HNMT Thr105Ile variant as a factor in disease development or a genetic link between the disorders. | Histamine N-methyltransferase Thr105Ile is not associated with Parkinson's disease or essential tremor.
Keeling BH, Vilariño-Güell C, Soto-Ortolaza AI, Ross OA, Uitti RJ, Rajput A, Wszolek ZK, Farrer MJ., Free PMC Article | 05/10/2010 |
| These results, combined with previous findings indicating alterations in the frequency for the HNMT Thr105Ile polymorphism in patients with PD, suggest that alterations of histamine homeostasis in the SNC are associated with risk of movement disorders. | The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor.
Ledesma MC, García-Martín E, Alonso-Navarro H, Martínez C, Jiménez-Jiménez FJ, Benito-León J, Puertas I, Rubio L, López-Alburquerque T, Agúndez JA. | 01/21/2010 |
| The HNMT 939A>G polymorphism lowers HNMT enzymatic activity by decreasing HNMT mRNA stability, which leads to an increase in the histamine level and contributes to the development of aspirin intolerant chronic urticaria. | Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria.
Kim SH, Kang YM, Kim SH, Cho BY, Ye YM, Hur GY, Park HS. | 01/21/2010 |
| Increased histamine levels in patients with atopic dermatitis may result, at least in part, from reduced enzymatic inactivation via HNMT. | Association of the histamine N-methyltransferase C314T (Thr105Ile) polymorphism with atopic dermatitis in Caucasian children.
Kennedy MJ, Loehle JA, Griffin AR, Doll MA, Kearns GL, Sullivan JE, Hein DW., Free PMC Article | 01/21/2010 |