| Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease. | Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease.
Chen CY, Chou FY, Chang YG, Ho CJ, Wu KC, Hsu CL, Chern Y, Lin CJ. | 02/4/2023 |
| Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma. | Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma.
Kunou S, Shimada K, Takai M, Sakamoto A, Aoki T, Hikita T, Kagaya Y, Iwamoto E, Sanada M, Shimada S, Hayakawa F, Oneyama C, Kiyoi H., Free PMC Article | 01/15/2022 |
| Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites. | Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites.
Miller SR, McGrath ME, Zorn KM, Ekins S, Wright SH, Cherrington NJ., Free PMC Article | 12/4/2021 |
| Hypoxia did not change expression of either hENT1, hENT2, or TK1. | Effect of hypoxia on human equilibrative nucleoside transporters hENT1 and hENT2 in breast cancer.
Krys D, Hamann I, Wuest M, Wuest F. | 06/13/2020 |
| two novel functional splice variants of equilibrative nucleoside transporter 2 (ENT2), which are present at the nuclear envelope, were identified. | Novel nuclear hENT2 isoforms regulate cell cycle progression via controlling nucleoside transport and nuclear reservoir.
Grañé-Boladeras N, Spring CM, Hanna WJ, Pastor-Anglada M, Coe IR., Free PMC Article | 08/5/2017 |
| Results showed that both SLC29A1 and SLC29A2 were expressed at lower levels in colon cancer cell lines originating from metastatic sites than from primary sites. | Differential expression of hENT1 and hENT2 in colon cancer cell lines.
Liu Y, Zuo T, Zhu X, Ahuja N, Fu T. | 03/4/2017 |
| Direct evidence for apical localization of ENT1 and integral expression of ENT2 in intestinal epithelial cells. | Localization and Expression of Nucleoside Transporters ENT1 and ENT2 in Polar Cells of Intestinal Epithelium.
Senyavina NV, Gerasimenko TN, Fomicheva KA, Tonevitskaya SA, Kaprin AD. | 02/18/2017 |
| these findings reveal the transcriptional repression of ENT1,2 as an innate protective response during acute pulmonary inflammation. | Repression of the equilibrative nucleoside transporters dampens inflammatory lung injury.
Morote-Garcia JC, Köhler D, Roth JM, Mirakaj V, Eldh T, Eltzschig HK, Rosenberger P., Free PMC Article | 10/19/2013 |
| Data suggest that SLC29A2 is localized to apical membrane of adult Sertoli cells. In contrast, SLC29A1 is located on basolateral membrane of Sertoli cells; SLC29A1 is primarily responsible for basolateral nucleoside uptake into Sertoli cells. | Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1.
Klein DM, Evans KK, Hardwick RN, Dantzler WH, Wright SH, Cherrington NJ., Free PMC Article | 08/31/2013 |
| Data show that ENT1, ENT2, ENT4 and CNT3 protein was detected on ovarian carcinoma cells in all effusions, with expression observed in 1-95% of tumor cells. | Nucleoside transporters are widely expressed in ovarian carcinoma effusions.
Bock AJ, Dong HP, Tropé CG, Staff AC, Risberg B, Davidson B. | 03/24/2012 |
| Studies show that ABCC4 and SLC29A2 expression were predictive of achieving CR, and the high expression of GSTP1 suggests that this may be a therapeutic target for relapsed AML. | A Phase II trial of gemcitabine and mitoxantrone for patients with acute myeloid leukemia in first relapse.
Advani AS, Shadman M, Ali-Osman F, Barker A, Rybicki L, Kalaycio M, Sekeres MA, de Castro CM, Diehl LF, Moore JO, Beaven A, Copelan E, Sobecks R, Talea P, Rizzieri DA. | 02/4/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Contribution of adenosine related genes to the risk of depression with disturbed sleep.
Gass N, Ollila HM, Utge S, Partonen T, Kronholm E, Pirkola S, Suhonen J, Silander K, Porkka-Heiskanen T, Paunio T. | 06/30/2010 |
| This evidence suggested that apical CNT3 and basolateral ENT2 are involved in proximal tubular reabsorption of adenosine and some nucleoside drugs and that apical ENT1 is involved in proximal tubular secretion of 2'-deoxyadenosine. | Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3.
Elwi AN, Damaraju VL, Kuzma ML, Mowles DA, Baldwin SA, Young JD, Sawyer MB, Cass CE. | 01/21/2010 |
| HIF-1alpha-dependent repression of ENT2 increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine. | Hypoxia-inducible factor-dependent repression of equilibrative nucleoside transporter 2 attenuates mucosal inflammation during intestinal hypoxia.
Morote-Garcia JC, Rosenberger P, Nivillac NM, Coe IR, Eltzschig HK. | 01/21/2010 |
| correlation between the recently described p53-inducible apoptosis gene TIGAR and both sensitivity to fludarabine and hENT2 expression in chronic lymphocytic leukemia cells. | Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells.
López-Guerra M, Trigueros-Motos L, Molina-Arcas M, Villamor N, Casado FJ, Montserrat E, Campo E, Colomer D, Pastor-Anglada M. | 01/21/2010 |
| hPMEC from pre-eclampsia exhibit increased total transport (hENT1+hENT2), and maximal velocity (Vmax) for hENT2- (2-fold), but reduced Vmax for hENT1-mediated adenosine transport | Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia.
Escudero C, Casanello P, Sobrevia L. | 01/21/2010 |
| Report expression and hepatobiliary transport characteristics of ENT2 in sandwich-cultured human hepatocytes. | Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.
Govindarajan R, Endres CJ, Whittington D, LeCluyse E, Pastor-Anglada M, Tse CM, Unadkat JD., Free PMC Article | 01/21/2010 |
| Human cardiac microvascular endothelial cells rely on ENT1 for nucleoside transport with little contribution from ENT2. | Nucleoside and nucleobase transporters of primary human cardiac microvascular endothelial cells: characterization of a novel nucleobase transporter.
Bone DB, Hammond JR. | 01/21/2010 |
| These data suggest that selected genes of the SLC28 and SLC29 families are not only targets of HIV-1 infection, but might also contribute to the development of adipose tissue alterations leading to lipodystrophy. | Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients.
Guallar JP, Cano-Soldado P, Aymerich I, Domingo JC, Alegre M, Domingo P, Villarroya F, Javier Casado F, Giralt M, Pastor-Anglada M. | 01/21/2010 |
| Data show that insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium. | Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium.
Muñoz G, San Martín R, Farías M, Cea L, Vecchiola A, Casanello P, Sobrevia L. | 01/21/2010 |
| Only a few endometrial carcinomas (15%) were found to be negative for hCNT1, but they all retained hENT1 and hENT2 expression. | Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.
Farré X, Guillén-Gómez E, Sánchez L, Hardisson D, Plaza Y, Lloberas J, Casado FJ, Palacios J, Pastor-Anglada M. | 01/21/2010 |
| the corresponding residues in TMs 1 and 11 of hENT1, hENT2, and CeENT1 are important for dipyridamole interactions and nucleoside transport. | Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters.
Visser F, Baldwin SA, Isaac RE, Young JD, Cass CE. | 01/21/2010 |
| role in functional and molecular characterization of nucleobase transport | Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation.
Yao SY, Ng AM, Vickers MF, Sundaram M, Cass CE, Baldwin SA, Young JD. | 01/21/2010 |
| an analysis of function by site-directed glycosylation mutagenesis | Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2.
Ward JL, Leung GP, Toan SV, Tse CM. | 01/21/2010 |
| residue 33 resides in an extracellular domain as predicted by the current hENT2 topology model and suggested that it is a functionally important component of both the permeant and dipyridamole binding sites. | Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites.
Visser F, Zhang J, Raborn RT, Baldwin SA, Young JD, Cass CE. | 01/21/2010 |