| Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish. | Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish.
Ouyang J, Li S, Sun W, Xiao X, Wang Y, Jiang Y, Zhang Q. | 01/14/2023 |
| A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia. | A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia.
Jiang F, Lang X, Chen N, Jin L, Liu L, Wei X, Pan J, Yu F, Blake A, Xiao S. | 06/25/2022 |
| Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding. | Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding.
Yamazaki T, Liu L, Conlon EG, Manley JL., Free PMC Article | 07/10/2021 |
| Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing. | Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing.
Pararajalingam P, Coyle KM, Arthur SE, Thomas N, Alcaide M, Meissner B, Boyle M, Qureshi Q, Grande BM, Rushton C, Slack GW, Mungall AJ, Tam CS, Agarwal R, Dawson SJ, Lenz G, Balasubramanian S, Gascoyne RD, Steidl C, Connors J, Villa D, Audas TE, Marra MA, Johnson NA, Scott DW, Morin RD., Free PMC Article | 03/20/2021 |
| Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1. | Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1.
Takahashi K, Fujiya M, Konishi H, Murakami Y, Iwama T, Sasaki T, Kunogi T, Sakatani A, Ando K, Ueno N, Kashima S, Moriichi K, Tanabe H, Okumura T., Free PMC Article | 03/13/2021 |
| demonstrate that hnRNP H1 and PTBP1 regulate TCF3 AS reciprocally, and that position-dependent interactions between these factors are essential for proper TCF3 MEAS | TCF3 mutually exclusive alternative splicing is controlled by long-range cooperative actions between hnRNPH1 and PTBP1.
Yamazaki T, Liu L, Manley JL., Free PMC Article | 01/11/2020 |
| LINC00162 overexpression increased the sensitivity, enhanced cell cycle arrest and apoptosis induced by 5-aza-dC, but did not affect its DNA demethylation effect. Mechanistically, LINC00162 interacted with an RNA splicing protein, HNRNPH1, and decreased splicing of an anti-apoptotic splicing variant, BCL-XL. LINC00162 may have translational value to predict patients who will respond to 5-aza-dC. | LINC00162 confers sensitivity to 5-Aza-2'-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1.
Zong L, Hattori N, Yasukawa Y, Kimura K, Mori A, Seto Y, Ushijima T. | 12/21/2019 |
| this study is the first to identify hnRNP F/H and K as regulators of Mcl-1 alternative splicing. | Regulation of Mcl-1 alternative splicing by hnRNP F, H1 and K in breast cancer cells.
Tyson-Capper A, Gautrey H., Free PMC Article | 09/14/2019 |
| Sequestration of hnRNP H altered the splicing of target transcripts in C9 amyotrophic lateral sclerosis patients with GGGGCC expansion in the C9ORF72 gene. Here, the show that this signature also occurs in half of 50 postmortem sporadic, amyotrophic lateral sclerosis/frontotemporal dementia brains lacking GGGGCC expansion in the C9ORF72 gene. | Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
Conlon EG, Fagegaltier D, Agius P, Davis-Porada J, Gregory J, Hubbard I, Kang K, Kim D, New York Genome Center ALS Consortium, Phatnani H, Shneider NA, Manley JL., Free PMC Article | 03/16/2019 |
| serum exosomal hnRNPH1 mRNA levels in hepatocellular carcinoma (HCC) patients were remarkably higher than in the other groups; exosomal hnRNPH1 mRNA levels in HCC patients were associated with the Child-Pugh classification, portal vein tumor emboli, lymph node metastasis, TNM stage and overall survival; findings suggested that serum exosomal hnRNPH1 mRNA could be an effective marker for HCC in high HBV prevalence areas | Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma.
Xu H, Dong X, Chen Y, Wang X. | 01/26/2019 |
| Together, these data implicate C9ORF72 GGGGCC expansion-mediated sequestration of hnRNP H as a significant contributor to neurodegeneration in C9 amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. | The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains.
Conlon EG, Lu L, Sharma A, Yamazaki T, Tang T, Shneider NA, Manley JL., Free PMC Article | 11/25/2017 |
| High HNRNPH1 expression is associated with castration-resistant prostate cancer. | Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.
Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, Jones JC, Mondal D, Ferrer M, Abdel-Mageed AB., Free PMC Article | 11/4/2017 |
| hnRNP H binds to two specific G-runs in exon 5a of ACHE and activates the distal alternative 3 splice site (ss) between exons 5a and 5b. Furthermore, hnRNP H competes for binding of CstF64 to the overlapping binding sites in exon 5a, and suppresses the selection of a cryptic polyadenylation site, which additionally ensures transcription of the distal 3 ss required for the generation of AChET isoform. | Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms.
Nazim M, Masuda A, Rahman MA, Nasrin F, Takeda JI, Ohe K, Ohkawara B, Ito M, Ohno K., Free PMC Article | 11/4/2017 |
| The different alternative transcript variants of HNRNPH1 exhibited different expression changes during tumorigenesis. Its mRNA and protein were overexpressed in esophageal squamous cell carcinoma and associated with poorer differentiation of tumor cells. | Protein and gene expression characteristics of heterogeneous nuclear ribonucleoprotein H1 in esophageal squamous cell carcinoma.
Sun YL, Liu F, Liu F, Zhao XH., Free PMC Article | 04/29/2017 |
| Our findings define novel roles for hnRNPH1 as a putative oncogene, splicing factor, and an auxiliary AR coregulator. | Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer.
Yang Y, Jia D, Kim H, Abd Elmageed ZY, Datta A, Davis R, Srivastav S, Moroz K, Crawford BE, Moparty K, Thomas R, Hudson RS, Ambs S, Abdel-Mageed AB., Free PMC Article | 12/24/2016 |
| Global splicing analysis with RNA-seq revealed that exons carrying the hnRNP H-binding GGGGG motif are predisposed to be skipped compared to those carrying the SRSF1-binding GGAGG motif in both human and mouse brains. | SRSF1 and hnRNP H antagonistically regulate splicing of COLQ exon 16 in a congenital myasthenic syndrome.
Rahman MA, Azuma Y, Nasrin F, Takeda J, Nazim M, Bin Ahsan K, Masuda A, Engel AG, Ohno K., Free PMC Article | 08/6/2016 |
| vRSF3 and hnRNP H1 are the first splicing factors identified which regulate the production of these functionally distinct HER2 splice variants and therefore maybe important for the regulation of HER2 signaling. | SRSF3 and hnRNP H1 regulate a splicing hotspot of HER2 in breast cancer cells.
Gautrey H, Jackson C, Dittrich AL, Browell D, Lennard T, Tyson-Capper A., Free PMC Article | 05/21/2016 |
| In pediatric T-acute lymphoblastic leukemia, we have identified 2 RNA processing genes, that is, HNRNPH1/5q35 and DDX3X/Xp11.3 as new MLLT10 fusion partners. | New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia.
Brandimarte L, Pierini V, Di Giacomo D, Borga C, Nozza F, Gorello P, Giordan M, Cazzaniga G, Te Kronnie G, La Starza R, Mecucci C. | 08/31/2013 |
| These results support a working hypothesis that a late viral protein HPV16 L1, which is down regulated by hnRNP H early in the viral life cycle may provide an auto-regulatory positive feedback loop that allows the rapid production of HPV capsid proteins through suppression of the function of hnRNP H at the late stage of the viral life cycle. | Specific interaction between hnRNP H and HPV16 L1 proteins: implications for late gene auto-regulation enabling rapid viral capsid protein production.
Zheng ZZ, Sun YY, Zhao M, Huang H, Zhang J, Xia NS, Miao J, Zhao Q. | 07/27/2013 |
| The REST N exon is a very versatile sequence with a complex array of splicing signals, and its activation in H69 cells depends on the relative amounts of hnRNP H and U2AF65. | Binding of hnRNP H and U2AF65 to respective G-codes and a poly-uridine tract collaborate in the N50-5'ss selection of the REST N exon in H69 cells.
Ortuño-Pineda C, Galindo-Rosales JM, Calderón-Salinas JV, Villegas-Sepúlveda N, Saucedo-Cárdenas O, De Nova-Ocampo M, Valdés J., Free PMC Article | 04/6/2013 |
| These results suggest that increased level of hnRNP-H and PDIA3 expression in Dengue virus infected THP1 cells assist in the viral replication by suppressing the TNF-alpha production. | Dengue virus infection induces upregulation of hn RNP-H and PDIA3 for its multiplication in the host cell.
Mishra KP, Shweta, Diwaker D, Ganju L. | 05/26/2012 |
| hnRNPH activity appears to be involved in the pathogenesis and progression of malignant gliomas as the centre of a splicing oncogenic switch | Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas.
Lefave CV, Squatrito M, Vorlova S, Rocco GL, Brennan CW, Holland EC, Pan YX, Cartegni L., Free PMC Article | 12/24/2011 |
| spatial interactions of hnRNPH1, NF45, and C14orf166 with HCVc174 likely modulate HCV or cellular functions during acute and chronic HCV infection | Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein.
Lee JW, Liao PC, Young KC, Chang CL, Chen SS, Chang TT, Lai MD, Wang SW. | 12/17/2011 |
| Insight on the crucial role of hnRNP H1 in the regulation of the alternative splicing of the rpL3 gene. | Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP.
Russo A, Catillo M, Esposito D, Briata P, Pietropaolo C, Russo G., Free PMC Article | 12/10/2011 |
| Nuclear heterogeneous nuclear ribonucleo-protein H expression was related to survival in colorectal cancer. | The expression profile of RNA-binding proteins in primary and metastatic colorectal cancer: relationship of heterogeneous nuclear ribonucleoproteins with prognosis.
Hope NR, Murray GI. | 04/2/2011 |