| A pan-cancer analysis of the role of HOXD1, HOXD3, and HOXD4 and validation in renal cell carcinoma. | A pan-cancer analysis of the role of HOXD1, HOXD3, and HOXD4 and validation in renal cell carcinoma.
Wang L, Wang X, Sun H, Wang W, Cao L., Free PMC Article | 10/24/2023 |
| Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis. | Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis.
Wang H, Zhou Z, Liu Y, Wang P, Chen L, Qi S, Xie J, Tang J. | 08/27/2022 |
| MeCP2 drives hepatocellular carcinoma progression via enforcing HOXD3 promoter methylation and expression through the HB-EGF/EGFR pathway. | MeCP2 drives hepatocellular carcinoma progression via enforcing HOXD3 promoter methylation and expression through the HB-EGF/EGFR pathway.
Wang L, Gao Y, Tong D, Wang X, Guo C, Guo B, Yang Y, Zhao L, Zhang J, Yang J, Qin Y, Liu L, Huang C., Free PMC Article | 07/9/2022 |
| HOXD3 Up-regulating KDM5C Promotes Malignant Progression of Diffuse Large B-Cell Lymphoma by Decreasing p53 Expression | HOXD3 Up-regulating KDM5C Promotes Malignant Progression of Diffuse Large B-Cell Lymphoma by Decreasing p53 Expression.
Cui Y, Lv C, Wen Y, Zhao D, Yang Y, Qiu H, Wang C., Free PMC Article | 04/16/2022 |
| HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway. | HOXD3 was negatively regulated by YY1 recruiting HDAC1 to suppress progression of hepatocellular carcinoma cells via ITGA2 pathway.
Wang L, Gao Y, Zhao X, Guo C, Wang X, Yang Y, Han C, Zhao L, Qin Y, Liu L, Huang C, Wang W., Free PMC Article | 09/5/2020 |
| Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced ITGB3 transcriptional activation and MAPK/AKT signaling. | Nuclear lncRNA HOXD-AS1 suppresses colorectal carcinoma growth and metastasis via inhibiting HOXD3-induced integrin β3 transcriptional activating and MAPK/AKT signalling.
Yang MH, Zhao L, Wang L, Ou-Yang W, Hu SS, Li WL, Ai ML, Wang YQ, Han Y, Li TT, Ding YQ, Wang S., Free PMC Article | 06/15/2019 |
| The findings indicate that miR-203a inhibits hepatocellular carcinoma cell invasion, metastasis, and angiogenesis by negatively targeting HOXD3 and suppressing cell signaling through the VEGFR pathway. | HOXD3 targeted by miR-203a suppresses cell metastasis and angiogenesis through VEGFR in human hepatocellular carcinoma cells.
Wang L, Tong D, Guo Q, Wang X, Wu F, Li Q, Yang J, Zhao L, Qin Y, Liu Y, Huang C., Free PMC Article | 12/22/2018 |
| EGR1 is a key player in the transcriptional control of miR-203a, and that miR-203a acts as an anti-oncogene to suppress HCC tumorigenesis by targeting HOXD3 through EGFR-related cell signaling pathways. | EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway.
Wang L, Sun H, Wang X, Hou N, Zhao L, Tong D, He K, Yang Y, Song T, Yang J, Huang C., Free PMC Article | 02/10/2018 |
| the HOXD3 gene promotes colorectal cancer cell growth and plays a pivotal role in the development and survival of malignant human colorectal cancer cells. | RNAi-mediated HOXD3 knockdown inhibits growth in human RKO cells.
Chen F, Sun G, Peng J., Free PMC Article | 03/18/2017 |
| These results validate the association between promoter hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence | Validation study of genes with hypermethylated promoter regions associated with prostate cancer recurrence.
Stott-Miller M, Zhao S, Wright JL, Kolb S, Bibikova M, Klotzle B, Ostrander EA, Fan JB, Feng Z, Stanford JL., Free PMC Article | 08/22/2015 |
| describe familial cases of TH in two generations (proband and his father), in addition to other two sporadic cases. We have found polymorphisms in the HOXB3, HOXD3, and a new synonymous variant, and PITX2 genes | The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis.
Kizys MM, Nesi-França S, Cardoso MG, Harada MY, Melo MC, Chiamolera MI, Dias-da-Silva MR, Maciel RM. | 11/22/2014 |
| HOXD3 promoter hypermethylation is correlated with clinicopathologic features in prostate cancer. This correlation is more common in older, higher risk patients. | Correlation of HOXD3 promoter hypermethylation with clinical and pathologic features in screening prostate biopsies.
Chen LN, Rubin RS, Othepa E, Cer C, Yun E, Agarwal RP, Collins BT, McGeagh K, Pahira J, Bandi G, Kowalczyk K, Kumar D, Dritschilo A, Collins SP, Bostwick DG, Lynch JH, Suy S., Free PMC Article | 06/14/2014 |
| High expression of HOXD3 correlates with invasive breast cancer. | Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer.
Shaoqiang C, Yue Z, Yang L, Hong Z, Lina Z, Da P, Qingyuan Z. | 03/23/2013 |
| quantitative increase in promoter methylation levels of HOXD3 is associated with prostate cancer progression | Association of tissue promoter methylation levels of APC, TGFβ2, HOXD3 and RASSF1A with prostate cancer progression.
Liu L, Kron KJ, Pethe VV, Demetrashvili N, Nesbitt ME, Trachtenberg J, Ozcelik H, Fleshner NE, Briollais L, van der Kwast TH, Bapat B. | 12/24/2011 |
| HOXD3 methylation distinguishes low-grade prostate cancers from intermediate and high-grade ones. | DNA methylation of HOXD3 as a marker of prostate cancer progression.
Kron KJ, Liu L, Pethe VV, Demetrashvili N, Nesbitt ME, Trachtenberg J, Ozcelik H, Fleshner NE, Briollais L, van der Kwast TH, Bapat B. | 07/26/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
Ester AR, Weymouth KS, Burt A, Wise CA, Scott A, Gurnett CA, Dobbs MB, Blanton SH, Hecht JT., Free PMC Article | 01/20/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group., Free PMC Article | 06/24/2009 |
| Further validation of candidate genes on a separate cohort of low and high grade prostate cancers by quantitative MethyLight analysis has allowed us to confirm DNA hypermethylation of HOXD3 and BMP7... | Discovery of novel hypermethylated genes in prostate cancer using genomic CpG island microarrays.
Kron K, Pethe V, Briollais L, Sadikovic B, Ozcelik H, Sunderji A, Venkateswaran V, Pinthus J, Fleshner N, van der Kwast T, Bapat B., Free PMC Article | 01/21/2010 |
| Study identified hypermethylation and gene inactivation of HOXA4 and HOXA5 was frequently observed (26-79%) in all types of leukemias studied. | Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis.
Strathdee G, Holyoake TL, Sim A, Parker A, Oscier DG, Melo JV, Meyer S, Eden T, Dickinson AM, Mountford JC, Jorgensen HG, Soutar R, Brown R. | 01/21/2010 |
| The karyotype of our patient suggests another possible locus of the Duane syndrome, and the mapped genes around the deleted region, 1q42.13-43, contain possible candidate genes such as a homeobox gene. | Interstitial deletion of 1q42.13-q43 with Duane retraction syndrome.
Kato Z, Yamagishi A, Kondo N. | 01/21/2010 |
| transduction of antisense DNA into human melanoma cells results in decreased invasive and motile activities | Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities.
Okubo Y, Hamada J, Takahashi Y, Tada M, Tsutsumida A, Furuuchi K, Aoyama T, Sugihara T, Moriuchi T. | 01/21/2010 |
| Hox D3 coordinately regulates the expression of integrin alpha5beta1 and integrin alphavbeta3 during angiogenesis in vivo. | The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis.
Boudreau NJ, Varner JA. | 01/21/2010 |
| HoxD3 may provide a means to directly improve collagen deposition, angiogenesis and closure in poorly healing diabetic wounds. | HoxD3 accelerates wound healing in diabetic mice.
Hansen SL, Myers CA, Charboneau A, Young DM, Boudreau N., Free PMC Article | 01/21/2010 |
| HOXD3 may play an important role in regulating cerebral angiogenesis, and that gene transfer of HOXD3 may provide a novel and potent means to stimulate angiogenesis | Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice.
Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, Yang GY. | 01/21/2010 |