| SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis. | SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis.
Wang L, Liang D, Huang Y, Chen Y, Yang X, Huang Z, Jiang Y, Su H, Wang L, Pathak JL, Ge L., Free PMC Article | 08/3/2023 |
| Local Pentraxin-2 Deficit Is a Feature of Intestinal Fibrosis in Crohn's Disease. | Local Pentraxin-2 Deficit Is a Feature of Intestinal Fibrosis in Crohn's Disease.
Levitte S, Peale FV, Jhun I, McBride J, Neighbors M. | 06/29/2023 |
| Proteomic-based identification of APCS as candidate protein for diagnosis of patients exhibiting anti-tubercular drug induced liver injury. | Proteomic-based identification of APCS as candidate protein for diagnosis of patients exhibiting anti-tubercular drug induced liver injury.
Kaur B, Dixit R, Bakshi S, Konar M, Sinha SK, Duseja AK, Sharma S., Free PMC Article | 06/28/2023 |
| Macrophages pretreated with SAP displayed reduced fungal phagocytosis, reduced secretion of inflammatory cytokines (IFN-gamma, IL-6, and TNF-alpha), and increased secretion of the anti-inflammatory cytokine IL-10. | Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines.
Behrens NE, Lipke PN, Pilling D, Gomer RH, Klotz SA., Free PMC Article | 05/18/2019 |
| Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component. | Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component.
Ozawa D, Nomura R, Mangione PP, Hasegawa K, Okoshi T, Porcari R, Bellotti V, Naiki H. | 02/2/2019 |
| The findings suggest that the F57I mutation affects the aggregation process of lysozyme resulting in the formation of cytotoxic species and that SAP is able to prevent cell death in the F57I flies by preventing accumulation of toxic F57I structures. | Serum Amyloid P Component Ameliorates Neurological Damage Caused by Expressing a Lysozyme Variant in the Central Nervous System of Drosophila melanogaster.
Helmfors L, Bergkvist L, Brorsson AC., Free PMC Article | 07/22/2017 |
| Data suggest that SAP (serum amyloid P-component) interacts with at least 33 proteins/ligands in plasma containing physiological calcium levels; these ligands can be categorized to include apolipoproteins, complement system proteins, coagulation proteins, and components that regulate proteolysis. | Serum Amyloid P Component (SAP) Interactome in Human Plasma Containing Physiological Calcium Levels.
Poulsen ET, Pedersen KW, Marzeda AM, Enghild JJ. | 05/20/2017 |
| Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects. | Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents.
Can U, Buyukinan M, Guzelant A, Ugur A, Karaibrahimoglu A, Yabancıun S. | 05/6/2017 |
| SNPs in APCS were associated with late age at onset in familial amyloid polyneuropathy. | Variants in RBP4 and AR genes modulate age at onset in familial amyloid polyneuropathy (FAP ATTRV30M).
Santos D, Coelho T, Alves-Ferreira M, Sequeiros J, Mendonça D, Alonso I, Lemos C, Sousa A., Free PMC Article | 12/31/2016 |
| Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. | DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice.
Cox N, Pilling D, Gomer RH., Free PMC Article | 10/31/2015 |
| Here, it is reported that X-ray analysis of the SAP complex with CPHPC and cadmium ions provides higher resolution detail of the interaction than is observed with calcium ions. | Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).
Kolstoe SE, Jenvey MC, Purvis A, Light ME, Thompson D, Hughes P, Pepys MB, Wood SP., Free PMC Article | 04/4/2015 |
| Compared to wildtype C57BL/6 mice, we find that in Apcs-/- "SAP knock-out" mice, bleomycin induces a more persistent inflammatory response and increased fibrosis. | Persistent lung inflammation and fibrosis in serum amyloid P component (APCs-/-) knockout mice.
Pilling D, Gomer RH., Free PMC Article | 01/31/2015 |
| The effects of SAP and Xiapex (Collagenase Clostridium histolyticum) on fibrocytes derived from Dupuytren's disease, was evaluated. | First identification of resident and circulating fibrocytes in Dupuytren's disease shown to be inhibited by serum amyloid P and Xiapex.
Iqbal SA, Hayton MJ, Watson JS, Szczypa P, Bayat A., Free PMC Article | 01/31/2015 |
| plasma protein serum amyloid P binds to FcgammaRI on monocytes to inhibit fibrocyte differentiation, and binds to FcgammaRIIa on neutrophils to reduce neutrophil adhesion. | Distinct Fcγ receptors mediate the effect of serum amyloid p on neutrophil adhesion and fibrocyte differentiation.
Cox N, Pilling D, Gomer RH., Free PMC Article | 10/25/2014 |
| In the late phase post-myocardial infarct there is a coordinated decrease in immune response-inflammation proteins, except for SAP which showed an increase related to the specific activation of the classical complement pathway. | Coordinated proteomic signature changes in immune response and complement proteins in acute myocardial infarction: the implication of serum amyloid P-component.
Cubedo J, Padró T, Badimon L. | 06/28/2014 |
| 9 different proteins (haptoglobin, transthyretin, apolipoprotein A-1, serum amyloid P component, apolipoprotein E, complement factor H, fibrinogen gamma, thrombin, complement C3) were identified as a potential diagnostic pattern of Parkinson's disease. | Parkinson's disease plasma biomarkers: an automated literature analysis followed by experimental validation.
Alberio T, Bucci EM, Natale M, Bonino D, Di Giovanni M, Bottacchi E, Fasano M. | 03/22/2014 |
| Human SAP binds phosphoethanolamine, while rabbits seem to have low levels of SAP that bind to a lesser extent. | CRP and SAP from different species have different membrane ligand specificities.
Mattecka S, Bock C, Vogt B, Yapici G, Schrödl W, Janko C, Schindler R, Sheriff A. | 12/14/2013 |
| These results indicate that SAP functions as a host defense factor, similar to other peptidoglycan recognition proteins and nucleotide-binding oligomerization domain-like receptors. | Human SAP is a novel peptidoglycan recognition protein that induces complement-independent phagocytosis of Staphylococcus aureus.
An JH, Kurokawa K, Jung DJ, Kim MJ, Kim CH, Fujimoto Y, Fukase K, Coggeshall KM, Lee BL., Free PMC Article | 11/16/2013 |
| SAP may act as an effective receptor mimic to limit influenza A virus infection of airway epithelial cells. | Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses.
Job ER, Bottazzi B, Gilbertson B, Edenborough KM, Brown LE, Mantovani A, Brooks AG, Reading PC., Free PMC Article | 09/21/2013 |
| Persons who develop non-affective psychoses have lower levels of certain acute phase proteins, including SAP, at the time of birth. | Neonatal levels of acute phase proteins and later risk of non-affective psychosis.
Gardner RM, Dalman C, Wicks S, Lee BK, Karlsson H., Free PMC Article | 08/31/2013 |
| [review] On the basis of structure, serum amyloid P component is a prototype of the short pentraxin family. | The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules.
Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B, Garlanda C. | 08/3/2013 |
| SAP has a new role in reducing the toxicity of early amyloidogenic aggregates in transthyretin amiloidosis. | Inhibition of TTR aggregation-induced cell death--a new role for serum amyloid P component.
Andersson K, Pokrzywa M, Dacklin I, Lundgren E., Free PMC Article | 07/20/2013 |
| observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation | FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.
Crawford JR, Pilling D, Gomer RH., Free PMC Article | 12/22/2012 |
| Low levels of serum amyloid P mark the brains of individuals who escape dementia despite the presence of beta amyloid plaques and tangles in Alzheimer's disease neuropathology. | Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology.
Crawford JR, Bjorklund NL, Taglialatela G, Gomer RH., Free PMC Article | 12/8/2012 |
| Studies indicate that pharmaceutical grade serum amyloid P component and C-reactive protein were isolated and purified. | Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use.
Pepys MB, Gallimore JR, Lloyd J, Li Z, Graham D, Taylor GW, Ellmerich S, Mangione PP, Tennent GA, Hutchinson WL, Millar DJ, Bennett G, More J, Evans D, Mistry Y, Poole S, Hawkins PN., Free PMC Article | 12/8/2012 |