| HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition. | HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition.
Wang S, Cheng H, Huang Y, Li M, Gao D, Chen H, Su R, Guo K. | 03/5/2024 |
| Extracellular Hsp90alpha stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. | Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress.
Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK., Free PMC Article | 10/8/2022 |
| Heat-shock protein 90alpha is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study. | Heat-shock protein 90α is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study.
Su K, Liu Y, Wang P, He K, Wang F, Chi H, Rao M, Li X, Wen L, Song Y, Zhang J, Gu T, Xu K, Li Q, Chen J, Wu Z, Li H, Huang W, Chen L, Tong J, Li H, Feng X, Chen S, Yang B, Jin H, Yang Y, Liu H, Yang C, Wu M, Xiong F, Peng K, Zhu L, Xu Y, Tang X, Tan Z, Luo X, Zheng H, Zhang Y, Guo L, Han Y., Free PMC Article | 10/8/2022 |
| Value of HSP90alpha in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study. | Value of HSP90α in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study.
Wang Y, Seyed Barghi SM, Yang Y, Akhavan-Sigari R. | 11/22/2021 |
| Heat shock protein 90alpha in nipple discharge as a potential tumor marker for breast cancer. | Heat shock protein 90α in nipple discharge as a potential tumor marker for breast cancer.
Wang YY, Liu C, Chen X, Ji J, Zhu SL, Sun Q, Zhang K, Zhu J, Zhao S, Wang YW, Ma R, Wang JL. | 11/6/2021 |
| Extracellular Hsp90alpha Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer. | Extracellular Hsp90α Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
Hou Q, Chen S, An Q, Li B, Fu Y, Luo Y., Free PMC Article | 08/7/2021 |
| Modulation of Human Hsp90alpha Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain. | Modulation of Human Hsp90α Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain.
Penkler DL, Tastan Bishop Ö., Free PMC Article | 08/29/2020 |
| High HSP90 alpha expression is associated with Endothelial-mesenchymal transition leading to exacerbate pancreatic ductal adenocarcinoma. | Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma.
Fan CS, Chen LL, Hsu TA, Chen CC, Chua KV, Li CP, Huang TS., Free PMC Article | 07/11/2020 |
| there was no difference in Hsp90alpha levels between overweight and obese children and healthy controls. Hsp90 isoforms had different expression in NAFLD patients. Also, Hsp90alpha levels were lower in overweight and obese NAFLD patients. However, Hsp90alpha to Hsp90beta ratio had better accuracy for NAFLD diagnosis in obese and overweight patients compared to individual biomarkers. | Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.
Bălănescu A, Stan I, Codreanu I, Comănici V, Bălănescu E, Bălănescu P., Free PMC Article | 05/9/2020 |
| Study suggests that HSP90AA2 gene polymorphisms are associated with SLE susceptibility in Chinese population. | Associations of HSP90AA2 gene polymorphisms with disease susceptibility, glucocorticoids efficacy and health-related quality of life in Chinese systemic lupus erythematosus patients.
Zhang M, Li SS, Xie QM, Xu JH, Sun XX, Pan FM, Xu SQ, Liu SX, Tao JH, Liu S, Cai J, Chen PL, Qian L, Wang CH, Liang CM, Huang HL, Pan HF, Su H, Zou YF. | 01/26/2019 |
| The Hsp90alpha binds human recombinant p23 about three times stronger than Hsp90beta but with significantly smaller exothermic enthalpy as determined by isothermal titration calorimetry of direct binding between the purified proteins. | Interaction of the middle domains stabilizes Hsp90α dimer in a closed conformation with high affinity for p23.
Synoradzki K, Miszta P, Kazlauskas E, Mickevičiūtė A, Michailovienė V, Matulis D, Filipek S, Bieganowski P. | 12/22/2018 |
| Knocking out Hsp90beta leads to tumour cell death. Extracellular supplementation with recombinant Hsp90alpha, but not Hsp90beta, protein recovers tumourigenicity of the Hsp90alpha-knockout cells. Sequential mutagenesis identifies two evolutionarily conserved lysine residues, lys-270 and lys-277, in the Hsp90alpha subfamily that determine the extracellular Hsp90alpha function. | Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression.
Zou M, Bhatia A, Dong H, Jayaprakash P, Guo J, Sahu D, Hou Y, Tsen F, Tong C, O'Brien K, Situ AJ, Schmidt T, Chen M, Ying Q, Ulmer TS, Woodley DT, Li W., Free PMC Article | 04/22/2017 |
| We revealed that Hsp90A and Hsp90B are partly colocalized with heparan sulfate proteoglycans (HSPGs) on the cell surface and that this colocalization was sensitive to heparin. | Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90α and Hsp90β to the cell plasma membrane.
Snigireva AV, Vrublevskaya VV, Afanasyev VN, Morenkov OS., Free PMC Article | 09/24/2016 |
| Heat shock protein 90 stimulates rat mesenchymal stem cell migration via PI3K/Akt and ERK1/2 pathways | Heat shock protein 90 stimulates rat mesenchymal stem cell migration via PI3K/Akt and ERK1/2 pathways.
Gao F, Hu X, Xie X, Liu X, Wang J. | 04/30/2016 |
| Studied the serum prolactin, cortisol, and ACTH stress response of intensive care unit (ICU) patients with severe sepsis/septic shock (SS) or systemic inflammatory response syndrome (SIRS) compared to healthy subjects. | Early response roles for prolactin cortisol and circulating and cellular levels of heat shock proteins 72 and 90α in severe sepsis and SIRS.
Vardas K, Apostolou K, Briassouli E, Goukos D, Psarra K, Botoula E, Tsagarakis S, Magira E, Routsi C, Nanas S, Briassoulis G., Free PMC Article | 06/6/2015 |
| These results indicate that cytoplasmic HSP90alpha may serve as a biomarker for perineural invasion in pancreatic cancer | Cytoplasmic HSP90α expression is associated with perineural invasion in pancreatic cancer.
Jiang H, Duan B, He C, Geng S, Shen X, Zhu H, Sheng H, Yang C, Gao H., Free PMC Article | 05/30/2015 |
| Increased expression of nucleated RBC, HSP90alpha and corresponding decreased expression of HO-2 in such hypoxic condition may play a protective role; to prevent cord blood RBC against stress induced damage during preeclampsia. | Differential expression of HSP90α and heme oxygenase in cord blood RBC during preeclampsia.
Ekambaram P, Jayachandran T, Dhakshinamoorthy L. | 07/6/2013 |
| Heat shock protein 90alpha is a substrate and chaperone of DNA-PK necessary for the apoptotic response. | Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response.
Solier S, Kohn KW, Scroggins B, Xu W, Trepel J, Neckers L, Pommier Y., Free PMC Article | 10/20/2012 |
| STAT5b pathway regulates Hsp90alpha expression under hypoxic conditions | Hypoxia upregulates Hsp90α expression via STAT5b in cancer cells.
Pak SH, Joung YH, Park JH, Lim EJ, Darvin P, Na YM, Hong DY, Lee B, Hwang TS, Park T, Ye SK, Moon ES, Cho BW, Park KD, Lee HK, Chung IM, Yang YM. | 09/1/2012 |
| HSP90alpha was an IMH-2 epitope-associated protein. Tumor HSP90alpha overexpression was correlated with the metastasis and poor prognosis of colorectal cancer patients. | Identification of heat shock protein 90α as an IMH-2 epitope-associated protein and correlation of its mRNA overexpression with colorectal cancer metastasis and poor prognosis.
Chen WS, Lee CC, Hsu YM, Chen CC, Huang TS. | 11/12/2011 |
| extracellular HSP90alpha transactivates EGFR/ErbB1 through TLR4 and a PKCdelta/c-Src pathway, which induces ATP release and cytosolic Ca(2+) increase and finally favors glioblastoma cell migration. | Transactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.
Thuringer D, Hammann A, Benikhlef N, Fourmaux E, Bouchot A, Wettstein G, Solary E, Garrido C., Free PMC Article | 03/26/2011 |
| High gene expression of Hsp90 alpha is associated with leukemia. | Heat-shock protein expression in leukemia.
Sedlackova L, Spacek M, Holler E, Imryskova Z, Hromadnikova I. | 01/29/2011 |
| extracellular Hsp90alpha promotes angiogenesis in an MMP-2-dependent manner. | The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis.
Song X, Wang X, Zhuo W, Shi H, Feng D, Sun Y, Liang Y, Fu Y, Zhou D, Luo Y., Free PMC Article | 01/15/2011 |
| that Hsp90alpha can be secreted by activated endothelial cells and is a positive regulator of angiogenesis, suggesting the potential application of Hsp90alpha as a stimulator for wound repair. | The regulatory mechanism of Hsp90alpha secretion from endothelial cells and its role in angiogenesis during wound healing.
Song X, Luo Y. | 08/23/2010 |
| Promoter activity analysis revealed that hepatitis B virus X protein is directly involved in the c-Myc-mediated transcriptional activation of HSP90alpha. | Hepatitis B virus X protein upregulates HSP90alpha expression via activation of c-Myc in human hepatocarcinoma cell line, HepG2.
Li W, Miao X, Qi Z, Zeng W, Liang J, Liang Z., Free PMC Article | 05/3/2010 |