| GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1. | GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization, mitochondria-targeting and -activating properties of human salivary histatin 1.
Ma D, Sun W, Fu C, Nazmi K, Veerman ECI, Jaspers RT, Bolscher JGM, Bikker FJ, Wu G., Free PMC Article | 08/20/2022 |
| Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma. | Association Between PD-L1 and Histatin1, 3 Expression in Advanced Head and Neck Squamous Cell Carcinoma.
Wongpanuwich W, Yodsanga S, Chaisuparat R, Amornphimoltham P. | 05/14/2022 |
| Histatin-1 is an endogenous ligand of the sigma-2 receptor. | Histatin-1 is an endogenous ligand of the sigma-2 receptor.
Son KN, Lee H, Shah D, Kalmodia S, Miller RC, Ali M, Balasubramaniam A, Cologna SM, Kong H, Shukla D, Aakalu VK., Free PMC Article | 12/25/2021 |
| Human salivary histatin-1 (Hst1) promotes bone morphogenetic protein 2 (BMP2)-induced osteogenesis and angiogenesis. | Human salivary histatin-1 (Hst1) promotes bone morphogenetic protein 2 (BMP2)-induced osteogenesis and angiogenesis.
Sun P, Shi A, Shen C, Liu Y, Wu G, Feng J., Free PMC Article | 11/6/2021 |
| Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells. | Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells.
Ma D, Sun W, Nazmi K, Veerman ECI, Bikker FJ, Jaspers RT, Bolscher JGM, Wu G., Free PMC Article | 02/27/2021 |
| Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study. | Presence of Histatin-1 in Human Tears and Association with Aqueous Deficient Dry Eye Diagnosis: A Preliminary Study.
Kalmodia S, Son KN, Cao D, Lee BS, Surenkhuu B, Shah D, Ali M, Balasubramaniam A, Jain S, Aakalu VK., Free PMC Article | 10/24/2020 |
| Histatin 1 is one of the most abundant histatins and recent reports show that it has a stimulating effect on cellular adherence, thereby suggesting a role in maintaining the quality of the epithelial barrier and stimulating mesenchymal-to-epithelial transition. | Salivary peptide histatin 1 mediated cell adhesion: a possible role in mesenchymal-epithelial transition and in pathologies.
van Dijk IA, Veerman ECI, Reits EAJ, Bolscher JGM, Stap J. | 06/22/2019 |
| salivary histatin-1 is a novel proangiogenic factor that may contribute to oral wound healing | The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis.
Torres P, Díaz J, Arce M, Silva P, Mendoza P, Lois P, Molina-Berríos A, Owen GI, Palma V, Torres VA. | 11/25/2017 |
| This study evaluated the effects of Hst1 on cellular barrier function. Hst1 counteracted the effects of epithelial-mesenchymal transition inducers on the outgrowth of oral cancer cell spheroids, suggesting that Hst1 affects processes that are implicated in cancer progression. | Human salivary peptide histatin-1 stimulates epithelial and endothelial cell adhesion and barrier function.
van Dijk IA, Ferrando ML, van der Wijk AE, Hoebe RA, Nazmi K, de Jonge WJ, Krawczyk PM, Bolscher JGM, Veerman ECI, Stap J. | 10/14/2017 |
| Histatin-1 is specifically expressed in human lacrimal epithelium. | Histatin-1 Expression in Human Lacrimal Epithelium.
Shah D, Ali M, Pasha Z, Jaboori AJ, Jassim SH, Jain S, Aakalu VK., Free PMC Article | 07/16/2016 |
| Histatins are salivary proteins with antimicrobial activity. | Structural relationship between human salivary histatins.
Troxler RF, Offner GD, Xu T, Vanderspek JC, Oppenheim FG. | 09/4/2014 |
| We investigated interactions among and functions of histatin 1 and the other proteins that are present in saliva by using high-throughput mass spectrometric techniques. This led to the identification of 43 proteins able to interact with histatin 1. | Identification and characterization of histatin 1 salivary complexes by using mass spectrometry.
Siqueira WL, Lee YH, Xiao Y, Held K, Wong W. | 05/11/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| These findings indicate that the regulation of the histatin gene expression may be intricate, and it seems to have a cell-type preference in the salivary gland cells. | Transcriptional regulation of the salivary histatin gene: finding of a strong positive regulatory element and its binding protein.
Imamura Y, Fujigaki Y, Oomori Y, Ouryouji K, Yanagisawa S, Miyazawa H, Wang PL. | 01/21/2010 |
| histatin 1 (Hst1) and histatin 2 (Hst2) as major wound-closing factors in human saliva | Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay.
Oudhoff MJ, Bolscher JG, Nazmi K, Kalay H, van 't Hof W, Amerongen AV, Veerman EC. | 01/21/2010 |
| The results allowed locating sulfation on the last four tyrosines (Tyr 27, 30, 34, and 36). | Tyrosine polysulfation of human salivary histatin 1. A post-translational modification specific of the submandibular gland.
Cabras T, Fanali C, Monteiro JA, Amado F, Inzitari R, Desiderio C, Scarano E, Giardina B, Castagnola M, Messana I. | 01/21/2010 |
| inhibits calcium phosphate precipitation | Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1.
Tamaki N, Tada T, Morita M, Watanabe T. | 01/21/2010 |