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    HTR1A 5-hydroxytryptamine receptor 1A [ Homo sapiens (human) ]

    Gene ID: 3350, updated on 27-Aug-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1 rs1049353 and an altered endocannabinoid system in depressed patients.

    Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1 rs1049353 and an altered endocannabinoid system in depressed patients.
    Obermanns J, Meiser H, Hoberg S, Vesterager CS, Schulz F, Juckel G, Emons B., Free PMC Article

    12/27/2023
    Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3beta.

    Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β.
    Harkin EF, Nasrallah G, Le François B, Albert PR., Free PMC Article

    11/29/2023
    ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.

    ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.
    Papageorgiou L, Christou E, Louka E, Papakonstantinou E, Diakou I, Pierouli K, Dragoumani K, Bacopoulou F, Chrousos GP, Eliopoulos E, Vlachakis D.

    10/28/2023
    Galpha Protein Signaling Bias at Serotonin 1A Receptor.

    Gα Protein Signaling Bias at Serotonin 1A Receptor.
    Alabdali R, Franchini L, Orlandi C., Free PMC Article

    10/28/2023
    Association between single-nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment.

    Association between single-nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment.
    Meyfarth SRS, Tavares JDS, Guimarães LDS, Silva EAB, Gaio DC, Ecker MB, Brancher JA, Küchler EC, Silva-Sousa AC, de Sousa-Neto MD, Antunes LAA, Antunes LS.

    08/19/2023
    The association between 5-HT1A binding and temporal lobe epilepsy: A meta-analysis of molecular imaging studies.

    The association between 5-HT1A binding and temporal lobe epilepsy: A meta-analysis of molecular imaging studies.
    Cai L, Xu Z, Luo H, He Q, Diao L, Gui X, Wei L.

    08/9/2023
    Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population.

    Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population.
    Wang F, Luo D, Chen J, Pan C, Wang Z, Fu H, Xu J, Yang M, Mo S, Zhuang L, Wang W., Free PMC Article

    05/13/2023
    HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-alpha2a and Oral Ribavirin (PEG-IFN-alpha2a/RBV).

    HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV).
    Pawlowski T, Malyszczak K, Pawlak D, Inglot M, Zalewska M, Grzywacz A, Radkowski M, Laskus T, Janocha-Litwin J, Frydecka D., Free PMC Article

    04/14/2023
    Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis.

    Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis.
    Hernández-Díaz Y, Tovilla-Zárate CA, Castillo-Avila RG, Juárez-Rojop IE, Genis-Mendoza AD, López-Narváez ML, Villar-Juárez GE, González-Castro TB.

    03/2/2023
    In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.

    In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.
    Bartlett EA, Yttredahl AA, Boldrini M, Tyrer AE, Hill KR, Ananth MR, Milak MS, Oquendo MA, Mann JJ, DeLorenzo C, Parsey RV., Free PMC Article

    02/27/2023
    Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development.

    Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development.
    Nikolić J, Vukojević K, Šoljić V, Mišković J, Orlović Vlaho M, Saraga-Babić M, Filipović N., Free PMC Article

    02/17/2023
    Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin1A receptor.

    Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin(1A) receptor.
    Kumar A, Sarkar P, Chattopadhyay A.

    02/4/2023
    HTR1A Inhibits the Progression of Triple-Negative Breast Cancer via TGF-beta Canonical and Noncanonical Pathways.

    HTR1A Inhibits the Progression of Triple-Negative Breast Cancer via TGF-β Canonical and Noncanonical Pathways.
    Liu Q, Sun H, Liu Y, Li X, Xu B, Li L, Jin W., Free PMC Article

    07/30/2022
    Oxidation of Membrane Lipids Alters the Activity of the Human Serotonin 1A Receptor.

    Oxidation of Membrane Lipids Alters the Activity of the Human Serotonin 1A Receptor.
    Elbaradei A, Wang Z, Malmstadt N.

    07/2/2022
    Effect of Hypoxia on the Function of the Human Serotonin1A Receptor.

    Effect of Hypoxia on the Function of the Human Serotonin(1A) Receptor.
    Dutta A, Sarkar P, Shrivastava S, Chattopadhyay A.

    05/14/2022
    Polymorphisms of the serotonin receptors genes in patients with bruxism: a systematic review.

    Polymorphisms of the serotonin receptors genes in patients with bruxism: a systematic review.
    Campello CP, Moraes SLD, Vasconcelos BCDE, Lima ELS, Pellizzer EP, Lemos CAA, Muniz MTC., Free PMC Article

    01/22/2022
    Does human serotonin-1A receptor polymorphism (rs6295) code for pain and associated symptoms in fibromyalgia syndrome?

    Does human serotonin-1A receptor polymorphism (rs6295) code for pain and associated symptoms in fibromyalgia syndrome?
    Tanwar S, Mattoo B, Kumar U, Dada R, Bhatia R.

    11/6/2021
    Effects of HTR1A rs6295 polymorphism on emotional attentional blink.

    Effects of HTR1A rs6295 polymorphism on emotional attentional blink.
    Tulver K, Bachmann M, Vaht M, Harro J, Bachmann T.

    10/2/2021
    Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples.

    Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples.
    Terock J, Weihs A, Teumer A, Klinger-König J, Janowitz D, Grabe HJ.

    09/25/2021
    Metabolic Depletion of Sphingolipids Reduces Cell Surface Population of the Human Serotonin1A Receptor due to Impaired Trafficking.

    Metabolic Depletion of Sphingolipids Reduces Cell Surface Population of the Human Serotonin(1A) Receptor due to Impaired Trafficking.
    Kumar A, Sarkar P, Chattopadhyay A.

    08/28/2021
    Polymorphisms in COMT, ADRB2 and HTR1A genes are associated with temporomandibular disorders in individuals with other arthralgias.

    Polymorphisms in COMT, ADRB2 and HTR1A genes are associated with temporomandibular disorders in individuals with other arthralgias.
    Bonato LL, Quinelato V, de Felipe Cordeiro PC, Vieira AR, Granjeiro JM, Tesch R, Casado PL.

    07/24/2021
    Membrane cholesterol regulates endocytosis and trafficking of the serotonin1A receptor: Insights from acute cholesterol depletion.

    Membrane cholesterol regulates endocytosis and trafficking of the serotonin(1A) receptor: Insights from acute cholesterol depletion.
    Kumar GA, Chattopadhyay A.

    07/3/2021
    An Association Between Serotonin 1A Receptor, Gray Matter Volume, and Sociability in Healthy Subjects and in Autism Spectrum Disorder.

    An Association Between Serotonin 1A Receptor, Gray Matter Volume, and Sociability in Healthy Subjects and in Autism Spectrum Disorder.
    Lefevre A, Richard N, Mottolese R, Leboyer M, Sirigu A.

    07/3/2021
    A functional HTR1A polymorphism, rs6295, predicts short-term response to lurasidone: confirmation with meta-analysis of other antipsychotic drugs.

    A functional HTR1A polymorphism, rs6295, predicts short-term response to lurasidone: confirmation with meta-analysis of other antipsychotic drugs.
    Yoshikawa A, Li J, Meltzer HY.

    04/3/2021
    A positron emission tomography occupancy study of brexpiprazole at dopamine D2 and D3 and serotonin 5-HT1A and 5-HT2A receptors, and serotonin reuptake transporters in subjects with schizophrenia.

    A positron emission tomography occupancy study of brexpiprazole at dopamine D(2) and D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors, and serotonin reuptake transporters in subjects with schizophrenia.
    Girgis RR, Forbes A, Abi-Dargham A, Slifstein M., Free PMC Article

    04/3/2021
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