| TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco. | TYK2, IFITM3, IFNAR2 and OAS3 single-nucleotide polymorphisms among severe COVID-19 ICU patients in Morocco.
Benmansour R, Tagajdid MR, El Hamzaoui H, Fjouji S, Doghmi N, Houba A, Belbacha I, Elkochri S, Aabi R, Elannaz H, Laraqui A, El Mchichi B, Chmitah T, Touil N, Ennibi K, Eljaoudi R, Elmir E, Amine Lahlou I, Oumzil H., Free PMC Article | 08/16/2024 |
| Association of IFNAR1 and IFNAR2 with COVID-19 severity. | Association of IFNAR1 and IFNAR2 with COVID-19 severity.
Yaugel-Novoa M, Bourlet T, Longet S, Botelho-Nevers E, Paul S., Free PMC Article | 07/23/2023 |
| Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19. | Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19.
Jalkanen J, Khan S, Elima K, Huttunen T, Wang N, Hollmén M, Elo LL, Jalkanen S., Free PMC Article | 03/20/2023 |
| Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19. | Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
Dieter C, de Almeida Brondani L, Lemos NE, Schaeffer AF, Zanotto C, Ramos DT, Girardi E, Pellenz FM, Camargo JL, Moresco KS, da Silva LL, Aubin MR, de Oliveira MS, Rech TH, Canani LH, Gerchman F, Leitão CB, Crispim D., Free PMC Article | 02/11/2023 |
| Deleterious single nucleotide polymorphisms (SNPs) of human IFNAR2 gene facilitate COVID-19 severity in patients: a comprehensive in silico approach. | Deleterious single nucleotide polymorphisms (SNPs) of human IFNAR2 gene facilitate COVID-19 severity in patients: a comprehensive in silico approach.
Akter S, Roy AS, Tonmoy MIQ, Islam MS. | 12/24/2022 |
| Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia. | Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia.
Hanrath AT, Hatton CF, Gothe F, Browne C, Vowles J, Leary P, Cockell SJ, Cowley SA, James WS, Hambleton S, Duncan CJA., Free PMC Article | 12/3/2022 |
| IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19. | IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19.
Fricke-Galindo I, Martínez-Morales A, Chávez-Galán L, Ocaña-Guzmán R, Buendía-Roldán I, Pérez-Rubio G, Hernández-Zenteno RJ, Verónica-Aguilar A, Alarcón-Dionet A, Aguilar-Duran H, Gutiérrez-Pérez IA, Zaragoza-García O, Alanis-Ponce J, Camarena A, Bautista-Becerril B, Nava-Quiroz KJ, Mejía M, Guzmán-Guzmán IP, Falfán-Valencia R., Free PMC Article | 09/3/2022 |
| Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic. | Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic.
Duncan CJA, Skouboe MK, Howarth S, Hollensen AK, Chen R, Børresen ML, Thompson BJ, Stremenova Spegarova J, Hatton CF, Stæger FF, Andersen MK, Whittaker J, Paludan SR, Jørgensen SE, Thomsen MK, Mikkelsen JG, Heilmann C, Buhas D, Øbro NF, Bay JT, Marquart HV, de la Morena MT, Klejka JA, Hirschfeld M, Borgwardt L, Forss I, Masmas T, Poulsen A, Noya F, Rouleau G, Hansen T, Zhou S, Albrechtsen A, Alizadehfar R, Allenspach EJ, Hambleton S, Mogensen TH., Free PMC Article | 04/30/2022 |
| Long non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2. | Long non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2.
Zheng Y, Guo Z, Li Y., Free PMC Article | 02/26/2022 |
| Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment. | Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment.
Aliaga-Gaspar P, Hurtado-Guerrero I, Ciano-Petersen NL, Urbaneja P, Brichette-Mieg I, Reyes V, Rodriguez-Bada JL, Alvarez-Lafuente R, Arroyo R, Quintana E, Ramió-Torrentà L, Alonso A, Leyva L, Fernández O, Oliver-Martos B., Free PMC Article | 02/19/2022 |
| IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. | IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs.
Shemesh M, Lochte S, Piehler J, Schreiber G. | 01/29/2022 |
| Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. | Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads.
Zanin N, Viaris de Lesegno C, Lamaze C, Blouin CM., Free PMC Article | 07/3/2021 |
| Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19. | Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.
Ma Y, Huang Y, Zhao S, Yao Y, Zhang Y, Qu J, Wu N, Su J., Free PMC Article | 06/26/2021 |
| Respirovirus C protein inhibits activation of type I interferon receptor-associated kinases to block JAK-STAT signaling. | Respirovirus C protein inhibits activation of type I interferon receptor-associated kinases to block JAK-STAT signaling.
Kitagawa Y, Yamaguchi M, Kohno M, Sakai M, Itoh M, Gotoh B. | 10/10/2020 |
| S27 of IFNalpha1 Contributes to Its Low Affinity for IFNAR2 and Weak Antiviral Activity | S27 of IFNα1 Contributes to Its Low Affinity for IFNAR2 and Weak Antiviral Activity.
Sharma N, O'Neal AJ, Gonzalez C, Wittling M, Gjinaj E, Parsons LM, Panda D, Khalenkov A, Scott D, Misra S, Rabin RL. | 05/23/2020 |
| Our data suggests that potential changes in the IFN responsiveness of mucosal immune cells during HIV infection are unlikely dictated by changes in IFNAR2 expression. | HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells.
Ickler J, Francois S, Widera M, Santiago ML, Dittmer U, Sutter K., Free PMC Article | 04/4/2020 |
| Significant associations were observed for 4 variants in IFNAR2, IFNLR1 with hepatitis B virus infection, and IFNLR1-rs4649203 was associated with hepatitis B recovery. Moreover, the authors demonstrated the clear relevance of 5 polymorphisms in IFNA1, IFNA2, IFNL4 with hepatocellular carcinoma. | Role of Functional IFNL4, IFNLR1, IFNA, IFNAR2 Polymorphisms in Hepatitis B virus-related liver disease in Han Chinese population.
Ma N, Zhang X, Yang L, Zhou J, Liu W, Gao X, Yu F, Zheng W, Ding S, Gao P, Yuan M, Liu D. | 10/20/2018 |
| The findings underline the roles of UL36USP-IFNAR2 interaction in counteracting the type I IFN-mediated signaling pathway and reveal a novel evasion mechanism of antiviral innate immunity by HSV-1. | Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity.
Yuan H, You J, You H, Zheng C., Free PMC Article | 09/22/2018 |
| Report lowered serum IFNAR2 levels in multiple sclerosis patients are elevated on treatment with interferon-beta. | Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker.
Órpez-Zafra T, Pavía J, Hurtado-Guerrero I, Pinto-Medel MJ, Rodriguez Bada JL, Urbaneja P, Suardíaz M, Villar LM, Comabella M, Montalban X, Alvarez-Cermeño JC, Leyva L, Fernández Ó, Oliver-Martos B. | 03/24/2018 |
| the level of IFNAR1, IFNAR2, and CCR5 mRNA expression was found to be significantly lower in the responders than nonresponders.Our results highlighted the significance of IFNAR and CCR5 genes in multiple sclerosis risk and the response to IFN-b therapy. | Immune response genes receptors expression and polymorphisms in relation to multiple sclerosis susceptibility and response to INF-β therapy.
Karam RA, Rezk NA, Amer MM, Fathy HA. | 09/2/2017 |
| this study shows that the surface expression levels of the common IFN-alpha/beta receptor subunit 2 are significantly higher on plasmacytoid dendritic cells from females in comparison to males | Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression.
Ziegler SM, Beisel C, Sutter K, Griesbeck M, Hildebrandt H, Hagen SH, Dittmer U, Altfeld M. | 07/8/2017 |
| A very small percentage of the pancreatic tumors showed strong expression of the IFNAR-2c. | Type I Interferon Receptor Expression in Human Pancreatic and Periampullary Cancer Tissue.
Booy S, Hofland LJ, Waaijers AM, Croze E, van Koetsveld PM, de Vogel L, Biermann K, van Eijck CH. | 11/12/2016 |
| Data suggest IFNA2 (interferon, alpha 2) binding to extracellular domain of IFNAR1 or IFNAR2 promotes proximity between intracellular domains; signaling depends on duration of activation/affinity of binding rather than specific conformational changes. | Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain.
Sharma N, Longjam G, Schreiber G., Free PMC Article | 07/16/2016 |
| The expression of IFNAR1, IFNgammaR1 and ribovarin transporters were significantly impaired in chronic liver disease and cirrhotic livers. | Impaired expression of type I and type II interferon receptors in HCV-associated chronic liver disease and liver cirrhosis.
Chandra PK, Gunduz F, Hazari S, Kurt R, Panigrahi R, Poat B, Bruce D, Cohen AJ, Bohorquez HE, Carmody I, Loss G, Balart LA, Wu T, Dash S., Free PMC Article | 10/3/2015 |
| Lack of expression of functional IFNAR2 does not seem to be the major cause of interferon resistance in hepatitis C virus patients receiving standard interferon therapy. | Detection of Interferon Alpha Receptor 2 in Interferon Resistant HCV Patients.
Trali GA, Naveed AK, Rasheed A, Bashir Q, Khan RS, Majeed A, Razak S. | 08/15/2015 |