| The rs7208505 Polymorphism and Differential Expression of the SKA2 Gene in the Prefrontal Cortex of Suicide Victims from the Mexican Population. | The rs7208505 Polymorphism and Differential Expression of the SKA2 Gene in the Prefrontal Cortex of Suicide Victims from the Mexican Population.
Valenzuela-García LI, Ayala-García VM, Ramos-Rosales DF, Jacquez-Flores RE, Urtiz-Estrada N, Hernández EMM, Barraza-Salas M. | 05/7/2024 |
| SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration. | SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Hartmann J, Bajaj T, Otten J, Klengel C, Ebert T, Gellner AK, Junglas E, Hafner K, Anderzhanova EA, Tang F, Missig G, Rexrode L, Trussell DT, Li KX, Pöhlmann ML, Mackert S, Geiger TM, Heinz DE, Lardenoije R, Dedic N, McCullough KM, Próchnicki T, Rhomberg T, Martinelli S, Payton A, Robinson AC, Stein V, Latz E, Carlezon WA Jr, Hausch F, Schmidt MV, Murgatroyd C, Berretta S, Klengel T, Pantazopoulos H, Ressler KJ, Gassen NC., Free PMC Article | 04/5/2024 |
| Decreased mononuclear cell NR3C1 SKA2 and FKPB5 expression levels among adult survivors of suicide bombing terror attacks in childhood are associated with the development of PTSD. | Decreased mononuclear cell NR3C1 SKA2 and FKPB5 expression levels among adult survivors of suicide bombing terror attacks in childhood are associated with the development of PTSD.
Goltser-Dubner T, Shalev A, Benarroch F, Canetti L, Yogev M, Kalla C, Masarwa R, Martin J, Pevzner D, Oz O, Saloner C, Amer R, Lavon M, Lotan A, Galili-Weisstub E, Segman R. | 12/23/2023 |
| Resting mononuclear cell NR3C1 and SKA2 expression levels predict blunted cortisol reactivity to combat training stress among elite army cadets exposed to childhood adversity. | Resting mononuclear cell NR3C1 and SKA2 expression levels predict blunted cortisol reactivity to combat training stress among elite army cadets exposed to childhood adversity.
Kalla C, Goltser-Dubner T, Pevzner D, Canetti L, Mirman A, Ben-Yehuda A, Itzhar N, Benarroch F, Shalev A, Giesser R, Fruchter E, Vashdi I, Oz O, Haber R, Saloner C, Lotan A, Galili-Weisstub E, Bonne O, Segman R. | 03/19/2022 |
| Circ_0008039 supports breast cancer cell proliferation, migration, invasion, and glycolysis by regulating the miR-140-3p/SKA2 axis. | Circ_0008039 supports breast cancer cell proliferation, migration, invasion, and glycolysis by regulating the miR-140-3p/SKA2 axis.
Dou D, Ren X, Han M, Xu X, Ge X, Gu Y, Wang X, Zhao S., Free PMC Article | 11/27/2021 |
| The Shift of HbF to HbA under Influence of SKA2 Gene; A Possible Link between Cortisol and Hematopoietic Maturation in Term and Preterm Newborns. | The Shift of HbF to HbA under Influence of SKA2 Gene; A Possible Link between Cortisol and Hematopoietic Maturation in Term and Preterm Newborns.
Ijabi J, Afrisham R, Moradi-Sardareh H, Roozehdar P, Seifi F, Sahebkar A, Ijabi R. | 11/13/2021 |
| Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma. | Transcript levels of spindle and kinetochore-associated complex 1/3 as prognostic biomarkers correlated with immune infiltrates in hepatocellular carcinoma.
Yu DC, Chen XY, Li X, Zhou HY, Yu DQ, Yu XL, Hu YC, Zhang RH, Zhang XB, Zhang K, An JD., Free PMC Article | 11/6/2021 |
| HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas. | HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas.
Sun Y, Xu D, Zhang C, Wang Y, Zhang L, Qiao D, Bu Y, Zhang Y., Free PMC Article | 07/31/2021 |
| Spindle and kinetochore-associated protein 2 facilitates the proliferation and invasion of hepatocellular carcinoma via the regulation of Wnt/beta-catenin signaling. | Spindle and kinetochore-associated protein 2 facilitates the proliferation and invasion of hepatocellular carcinoma via the regulation of Wnt/β-catenin signaling.
Jiang J, Xu B, Zheng Y, Guo X, Chen F. | 03/6/2021 |
| SKA2 promotes proliferation and invasion of hepatocellular carcinoma cells via activating the beta-catenin signaling pathway. | SKA2 promotes proliferation and invasion of hepatocellular carcinoma cells via activating the β-catenin signaling pathway.
Wang D, Suo YJ, Gong L, Lv SQ. | 11/21/2020 |
| The results of the current study suggest that prognosis of women with the AA genotype are more susceptible to be spontaneous preterm birth. | SKA2 gene - A novel biomarker for latent anxiety and preterm birth prediction.
Ijabi J, Moradi-Sardareh H, Afrisham R, Seifi F, Ijabi R. | 12/21/2019 |
| Breast cancer patients with lower expression levels of either PRR11 or SKA2, along with wild type p53, exhibited better disease-free survival compared to others with p53 mutations and/or higher expression levels of either PRR11 or SKA2. Study indicates that the PRR11 and SKA2 transcription unit might be an oncogenic contributor. | PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer.
Wang Y, Zhang C, Mai L, Niu Y, Wang Y, Bu Y., Free PMC Article | 06/22/2019 |
| SKA2 may be associated with breast cancer metastasis. | SKA2 mediates invasion and metastasis in human breast cancer via EMT.
Ren Z, Yang T, Zhang P, Liu K, Liu W, Wang P. | 06/1/2019 |
| We aimed to explore the biological activity of lncRNA SPRY4-IT1 in breast cancer cells and whether N-terminal polypeptide derived from viral macrophage inflammatory protein II (NT21MP) could exert its anti-tumor effect by regulating lncRNA SPRY4-IT1 and its target gene SKA2 | The N-terminal polypeptide derived from vMIP-II exerts its anti-tumor activity in human breast cancer by regulating lncRNA SPRY4-IT1.
Wu H, Wang Y, Chen T, Li Y, Wang H, Zhang L, Chen S, Wang W, Yang Q, Chen C., Free PMC Article | 05/18/2019 |
| decreased neuronal cell SKA complex genes' expression levels affect neuronal cell viability and neurite development | The stress response HPA-axis hormone, glucocorticoid, reduces cellular SKA complex gene expression.
Zhao J, Zhang P, He Z, Chen S, Golden T, Li L, Li M, Wu N. | 11/3/2018 |
| study shows that decreased gene and protein expression of SKA2 observed in the prefrontal cortex of suicide victims is specific to suicide, which was not observed in the brain of nonsuicidal patients. It also indicates reduced SKA2 expression in suicide is independent of psychiatric diagnosis, since it is observed in all diagnostic groups studied. | The Expression of the Suicide-Associated Gene SKA2 Is Decreased in the Prefrontal Cortex of Suicide Victims but Not of Nonsuicidal Patients.
Pandey GN, Rizavi HS, Zhang H, Bhaumik R, Ren X., Free PMC Article | 01/20/2018 |
| Possible association between SKA2 expression in prefrontal cortex and MDD. | GLUCOCORTICOID RECEPTOR-RELATED GENES: GENOTYPE AND BRAIN GENE EXPRESSION RELATIONSHIPS TO SUICIDE AND MAJOR DEPRESSIVE DISORDER.
Yin H, Galfalvy H, Pantazatos SP, Huang YY, Rosoklija GB, Dwork AJ, Burke A, Arango V, Oquendo MA, Mann JJ., Free PMC Article | 12/23/2017 |
| Data show that HOTAIR might act as an endogenous 'sponge' of miR-141, thereby regulating the derepression of SKA2. | Epigenetic modification of miR-141 regulates SKA2 by an endogenous 'sponge' HOTAIR in glioma.
Bian EB, Ma CC, He XJ, Wang C, Zong G, Wang HL, Zhao B., Free PMC Article | 12/23/2017 |
| The study adds evidence that CREB, a tumor oncogene, promotes renal cell carcinoma proliferation. It probably achieves this by increasing SKA2 expression | Cyclic AMP responsive element-binding protein promotes renal cell carcinoma proliferation probably via the expression of spindle and kinetochore-associated protein 2.
Zhuang H, Meng X, Li Y, Wang X, Huang S, Liu K, Hehir M, Fang R, Jiang L, Zhou JX, Wang P, Ren Y., Free PMC Article | 12/9/2017 |
| Kinetochores mature through Ska1/ska2/Ska3 complex recruitment and this is required for improved load-bearing capacity and silencing of the spindle assembly checkpoint. | Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment.
Auckland P, Clarke NI, Royle SJ, McAinsh AD., Free PMC Article | 09/16/2017 |
| p53 negatively regulates the expression of the PRR11-SKA2 bidirectional transcription unit through NF-Y, suggesting that the inability to repress the PRR11-SKA2 bidirectional transcription unit after loss of p53 might contribute to tumorigenesis. | The PRR11-SKA2 Bidirectional Transcription Unit Is Negatively Regulated by p53 through NF-Y in Lung Cancer Cells.
Wang Y, Weng H, Zhang Y, Long Y, Li Y, Niu Y, Song F, Bu Y., Free PMC Article | 04/22/2017 |
| these data establish the importance of SKA2 for cortisol stress responsivity and the development of post-traumatic stress disorder and provide further evidence that SKA2 is a promising biomarker for stress-related disorders including PTSD. | SKA2 Methylation is Involved in Cortisol Stress Reactivity and Predicts the Development of Post-Traumatic Stress Disorder (PTSD) After Military Deployment.
Boks MP, Rutten BP, Geuze E, Houtepen LC, Vermetten E, Kaminsky Z, Vinkers CH., Free PMC Article | 12/17/2016 |
| Results suggest that DNA methylation(adj) of SKA2 in blood indexes stress-related psychiatric phenotypes and neurobiology, pointing to its potential value as a biomarker of stress exposure and susceptibility. | SKA2 methylation is associated with decreased prefrontal cortical thickness and greater PTSD severity among trauma-exposed veterans.
Sadeh N, Spielberg JM, Logue MW, Wolf EJ, Smith AK, Lusk J, Hayes JP, Sperbeck E, Milberg WP, McGlinchey RE, Salat DH, Carter WC, Stone A, Schichman SA, Humphries DE, Miller MW., Free PMC Article | 11/19/2016 |
| DNA methylation of the SKA2 gene has been implicated as a biomarker of suicide risk and posttraumatic stress disorder. | EPIGENETIC VARIATION AT SKA2 PREDICTS SUICIDE PHENOTYPES AND INTERNALIZING PSYCHOPATHOLOGY.
Sadeh N, Wolf EJ, Logue MW, Hayes JP, Stone A, Griffin LM, Schichman SA, Miller MW., Free PMC Article | 11/5/2016 |
| SKA2 is hypothesized to reduce the ability to suppress cortisol following stress. | Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder.
Kaminsky Z, Wilcox HC, Eaton WW, Van Eck K, Kilaru V, Jovanovic T, Klengel T, Bradley B, Binder EB, Ressler KJ, Smith AK., Free PMC Article | 05/14/2016 |